Aliases for RNF144B Gene
External Ids for RNF144B Gene
Previous HGNC Symbols for RNF144B Gene
Previous GeneCards Identifiers for RNF144B Gene
GeneCards Summary for RNF144B Gene
RNF144B (Ring Finger Protein 144B) is a Protein Coding gene. Among its related pathways are Innate Immune System and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF144A.
UniProtKB/Swiss-Prot for RNF144B Gene
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.