Aliases for RNF144A Gene
External Ids for RNF144A Gene
Previous HGNC Symbols for RNF144A Gene
Previous GeneCards Identifiers for RNF144A Gene
This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Mar 2017]
GeneCards Summary for RNF144A Gene
RNF144A (Ring Finger Protein 144A) is a Protein Coding gene. Diseases associated with RNF144A include Parkinson Disease, Late-Onset. Among its related pathways are Metabolism of proteins and Protein ubiquitination. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is RNF144B.
UniProtKB/Swiss-Prot Summary for RNF144A Gene
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC.