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Aliases for RNF141 Gene

Aliases for RNF141 Gene

  • Ring Finger Protein 141 2 3 5
  • Zinc Finger Protein 230 3 4
  • ZNF230 3 4
  • C3HC4-Like Zinc Finger Protein 3
  • RING Finger Protein 141 3
  • RFP141 3
  • ZFP26 3

External Ids for RNF141 Gene

Previous GeneCards Identifiers for RNF141 Gene

  • GC11M010575
  • GC11M010500
  • GC11M010497
  • GC11M010489
  • GC11M010533
  • GC11M010205
  • GC11M010513
  • GC11M010518
  • GC11M010522
  • GC11M010527
  • GC11M010541
  • GC11M010556
  • GC11M010563
  • GC11M010568

Summaries for RNF141 Gene

Entrez Gene Summary for RNF141 Gene

  • The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as a testis specific transcription factor during spermatogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF141 Gene

RNF141 (Ring Finger Protein 141) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF141 Gene

  • May be involved in spermatogenesis.

Additional gene information for RNF141 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF141 Gene

Genomics for RNF141 Gene

GeneHancer (GH) Regulatory Elements for RNF141 Gene

Promoters and enhancers for RNF141 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J010539 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 655.5 +0.2 193 2.5 HDGF ARID4B SIN3A YY1 POLR2B E2F8 ZNF207 ZNF143 KLF13 SP3 MRVI1-AS1 RNF141 ZBED5 GC11M010587 GC11M010581
GH11J010538 Enhancer 0.7 Ensembl ENCODE 659.3 +2.0 1952 0.7 GATA3 FOXA2 FOXA3 FOSL2 FOS FOXA1 MRVI1-AS1 RNF141 GC11M010587 GC11M010581
GH11J010588 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 20.5 -50.8 -50788 7.3 HDAC1 ATF1 PKNOX1 TAF9B ARNT TCF12 FOS ETV6 ATF7 NCOA1 MRVI1-AS1 RNF141 MRVI1 AMPD3 LYVE1 GC11M010584
GH11J010622 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 16.3 -82.8 -82764 2.4 CTCF RAD21 CC2D1A CTBP1 EGR1 ARID2 POLR2A SMC3 ETV6 ZNF639 RNF141 CTR9 MRVI1 MRVI1-AS1 SBF2 AMPD3 LYVE1 GC11M010667
GH11J010502 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 18.7 +37.7 37729 2.2 MAX RNF141 MRVI1-AS1 AMPD3 CTR9 LYVE1 MRVI1 SBF2 ZBED5 EIF4G2 MIR4485
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF141 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF141 gene promoter:
  • ATF-2
  • MZF-1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B

Genomic Locations for RNF141 Gene

Genomic Locations for RNF141 Gene
29,553 bases
Minus strand
29,553 bases
Minus strand

Genomic View for RNF141 Gene

Genes around RNF141 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF141 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF141 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF141 Gene

Proteins for RNF141 Gene

  • Protein details for RNF141 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 141
    Protein Accession:
    Secondary Accessions:
    • A8K149
    • Q9NZB4

    Protein attributes for RNF141 Gene

    230 amino acids
    Molecular mass:
    25535 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNF141 Gene

    Alternative splice isoforms for RNF141 Gene


neXtProt entry for RNF141 Gene

Post-translational modifications for RNF141 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF141 Gene

No data available for DME Specific Peptides for RNF141 Gene

Domains & Families for RNF141 Gene

Gene Families for RNF141 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RNF141 Gene

Suggested Antigen Peptide Sequences for RNF141 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF141: view

No data available for UniProtKB/Swiss-Prot for RNF141 Gene

Function for RNF141 Gene

Molecular function for RNF141 Gene

UniProtKB/Swiss-Prot Function:
May be involved in spermatogenesis.

Phenotypes From GWAS Catalog for RNF141 Gene

Gene Ontology (GO) - Molecular Function for RNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF141: view
genes like me logo Genes that share phenotypes with RNF141: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF141 Gene

Localization for RNF141 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF141 Gene

Membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF141 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RNF141: view

Pathways & Interactions for RNF141 Gene

SuperPathways for RNF141 Gene

No Data Available

Interacting Proteins for RNF141 Gene

Gene Ontology (GO) - Biological Process for RNF141 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0051865 protein autoubiquitination IDA 24105792
genes like me logo Genes that share ontologies with RNF141: view

No data available for Pathways by source and SIGNOR curated interactions for RNF141 Gene

Drugs & Compounds for RNF141 Gene

No Compound Related Data Available

Transcripts for RNF141 Gene

mRNA/cDNA for RNF141 Gene

Unigene Clusters for RNF141 Gene

Ring finger protein 141:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF141 Gene

No ASD Table

Relevant External Links for RNF141 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF141 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF141 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF141 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.3).

Protein differential expression in normal tissues from HIPED for RNF141 Gene

This gene is overexpressed in Bone (54.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF141 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF141 Gene:


SOURCE GeneReport for Unigene cluster for RNF141 Gene:


mRNA Expression by UniProt/SwissProt for RNF141 Gene:

Tissue specificity: Isoform 1 is testis-specific. Isoform 2 is expressed in heart, brain, skeletal muscle, kidney and pancreas. Isoform 1 is not expressed in fetus or in azoospermic patients.

Evidence on tissue expression from TISSUES for RNF141 Gene

  • Nervous system(4.9)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with RNF141: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF141 Gene

Orthologs for RNF141 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF141 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF141 34 33
  • 99.57 (n)
(Canis familiaris)
Mammalia RNF141 34 33
  • 95.36 (n)
(Bos Taurus)
Mammalia RNF141 34 33
  • 94.93 (n)
(Mus musculus)
Mammalia Rnf141 16 34 33
  • 92.61 (n)
(Rattus norvegicus)
Mammalia rnf141 33
  • 92.46 (n)
(Monodelphis domestica)
Mammalia RNF141 34
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia RNF141 34
  • 91 (a)
(Gallus gallus)
Aves RNF141 34 33
  • 77.54 (n)
(Anolis carolinensis)
Reptilia RNF141 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf141 33
  • 72.81 (n)
(Danio rerio)
Actinopterygii rnf141 34 33
  • 69.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000736 33
  • 45.56 (n)
(Caenorhabditis elegans)
Secernentea F54B11.5 34
  • 28 (a)
Species where no ortholog for RNF141 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF141 Gene

Gene Tree for RNF141 (if available)
Gene Tree for RNF141 (if available)
Evolutionary constrained regions (ECRs) for RNF141: view image

Paralogs for RNF141 Gene Pseudogenes for RNF141 Gene

genes like me logo Genes that share paralogs with RNF141: view

No data available for Paralogs for RNF141 Gene

Variants for RNF141 Gene

Sequence variations from dbSNP and Humsavar for RNF141 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000220279 -- 10,527,044(-) T/G intron_variant
rs1000299471 -- 10,536,653(-) A/G intron_variant
rs1000328860 -- 10,533,687(-) A/C intron_variant
rs1000433200 -- 10,516,890(-) T/C intron_variant
rs1000443536 -- 10,533,949(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF141 Gene

Variant ID Type Subtype PubMed ID
esv3625358 CNV gain 21293372
nsv1044011 CNV gain 25217958
nsv7675 CNV insertion 18451855
nsv819964 CNV loss 19587683
nsv972946 CNV duplication 23825009

Variation tolerance for RNF141 Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF141 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF141 Gene

Disorders for RNF141 Gene

Additional Disease Information for RNF141

No disorders were found for RNF141 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF141 Gene

Publications for RNF141 Gene

  1. The shorter zinc finger protein ZNF230 gene message is transcribed in fertile male testes and may be related to human spermatogenesis. (PMID: 11672448) Zhang S … Vogt PH (The Biochemical journal 2001) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The zinc finger domain of RING finger protein 141 reveals a unique RING fold. (PMID: 28547869) Miyamoto K … Saito K (Protein science : a publication of the Protein Society 2017) 3 58
  4. Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. (PMID: 25807930) Broncel M … Tate EW (Angewandte Chemie (International ed. in English) 2015) 4 58
  5. Protein microarray characterization of the S-nitrosoproteome. (PMID: 24105792) Lee YI … Dawson TM (Molecular & cellular proteomics : MCP 2014) 3 58

Products for RNF141 Gene

Sources for RNF141 Gene

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