Aliases for RNF138 Gene
- Ring Finger Protein 138 2 3 5
- Ring Finger Protein 138, E3 Ubiquitin Protein Ligase 2 3
- Nemo-Like Kinase Associated Ring Finger Protein 2 3
- Nemo-Like Kinase-Associated RING Finger Protein 3 4
- RING-Type E3 Ubiquitin Transferase RNF138 3 4
- E3 Ubiquitin-Protein Ligase RNF138 3 4
- NLK-Associated RING Finger Protein 3 4
External Ids for RNF138 Gene
Previous GeneCards Identifiers for RNF138 Gene
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNF138 Gene
RNF138 (Ring Finger Protein 138) is a Protein Coding gene. Diseases associated with RNF138 include Episodic Ataxia, Type 2 and Episodic Ataxia. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein kinase binding and ligase activity. An important paralog of this gene is RNF166.
UniProtKB/Swiss-Prot Summary for RNF138 Gene
E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285).