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Aliases for RNF133 Gene

Aliases for RNF133 Gene

  • Ring Finger Protein 133 2 3 5
  • RING-Type E3 Ubiquitin Transferase RNF133 3 4
  • E3 Ubiquitin-Protein Ligase RNF133 3
  • RING Finger Protein 133 4
  • EC 4

External Ids for RNF133 Gene

Previous GeneCards Identifiers for RNF133 Gene

  • GC07M121878
  • GC07M121892
  • GC07M121931
  • GC07M122125
  • GC07M122337
  • GC07M116700

Summaries for RNF133 Gene

Entrez Gene Summary for RNF133 Gene

  • The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene has no intron. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF133 Gene

RNF133 (Ring Finger Protein 133) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is RNF128.

UniProtKB/Swiss-Prot for RNF133 Gene

  • Has E3 ubiquitin-protein ligase activity.

Additional gene information for RNF133 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF133 Gene

Genomics for RNF133 Gene

GeneHancer (GH) Regulatory Elements for RNF133 Gene

Promoters and enhancers for RNF133 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J122677 Enhancer 0.9 ENCODE 15.9 +20.2 20169 2.6 CLOCK FOXA2 MLX ARID4B NEUROD1 DMAP1 ATF7 FOS SP5 PPARG RNF133 RNF148 RPS26P31 ENSG00000225795 CADPS2
GH07J122633 Enhancer 0.5 FANTOM5 10.9 +65.6 65599 0.3 IKZF2 SPI1 RNF133 RNF148 CADPS2 ENSG00000225795 LOC105375481
GH07J122736 Enhancer 0.4 ENCODE 11.4 -37.3 -37259 0.2 NANOG IKZF1 ZSCAN5C RNF133 RNF148 LOC100422456 CADPS2
GH07J122652 Enhancer 0.4 ENCODE 10.8 +46.2 46174 0.2 FOXA2 HOMEZ RNF133 RNF148 ENSG00000225795 LOC105375481 CADPS2
GH07J122674 Enhancer 0.2 ENCODE 11.7 +24.5 24464 0.3 ENSG00000225795 RNF133 RNF148 LOC105375481 CADPS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF133 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF133 gene promoter:
  • Nkx2-5
  • Max1
  • c-Myc
  • CUTL1
  • FOXF2
  • Nkx6-1
  • Tal-1beta
  • E47
  • POU3F2
  • POU3F2 (N-Oct-5b)

Genomic Locations for RNF133 Gene

Genomic Locations for RNF133 Gene
1,445 bases
Minus strand
1,445 bases
Minus strand

Genomic View for RNF133 Gene

Genes around RNF133 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF133 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF133 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF133 Gene

Proteins for RNF133 Gene

  • Protein details for RNF133 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF133
    Protein Accession:
    Secondary Accessions:
    • A4D0W2
    • Q8N7G7

    Protein attributes for RNF133 Gene

    376 amino acids
    Molecular mass:
    42294 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF133 Gene

Post-translational modifications for RNF133 Gene

Other Protein References for RNF133 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF133 Gene

Domains & Families for RNF133 Gene

Gene Families for RNF133 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for RNF133 Gene

Suggested Antigen Peptide Sequences for RNF133 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF133: view

No data available for UniProtKB/Swiss-Prot for RNF133 Gene

Function for RNF133 Gene

Molecular function for RNF133 Gene

UniProtKB/Swiss-Prot Function:
Has E3 ubiquitin-protein ligase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme Numbers (IUBMB) for RNF133 Gene

Gene Ontology (GO) - Molecular Function for RNF133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF133: view
genes like me logo Genes that share phenotypes with RNF133: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF133 Gene

Localization for RNF133 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF133 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF133 gene
Compartment Confidence
endoplasmic reticulum 4
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RNF133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF133: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNF133 Gene

Pathways & Interactions for RNF133 Gene

SuperPathways for RNF133 Gene

No Data Available

UniProtKB/Swiss-Prot Q8WVZ7-RN133_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for RNF133 Gene

Gene Ontology (GO) - Biological Process for RNF133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0051865 protein autoubiquitination IEA --
genes like me logo Genes that share ontologies with RNF133: view

No data available for Pathways by source and SIGNOR curated interactions for RNF133 Gene

Drugs & Compounds for RNF133 Gene

No Compound Related Data Available

Transcripts for RNF133 Gene

mRNA/cDNA for RNF133 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF133 Gene

Ring finger protein 133:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF133 Gene

No ASD Table

Relevant External Links for RNF133 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF133 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF133 Gene

mRNA differential expression in normal tissues according to GTEx for RNF133 Gene

This gene is overexpressed in Testis (x44.8).

Protein differential expression in normal tissues from HIPED for RNF133 Gene

This gene is overexpressed in Frontal cortex (62.8) and Ovary (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF133 Gene

Protein tissue co-expression partners for RNF133 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF133 Gene:


SOURCE GeneReport for Unigene cluster for RNF133 Gene:

genes like me logo Genes that share expression patterns with RNF133: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF133 Gene

Orthologs for RNF133 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF133 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF133 33
  • 99.65 (n)
(Bos Taurus)
Mammalia RNF133 33
  • 83.07 (n)
(Mus musculus)
Mammalia Rnf133 16 34 33
  • 81.02 (n)
(Rattus norvegicus)
Mammalia Rnf133 33
  • 80.8 (n)
(Canis familiaris)
Mammalia RNF133 33
  • 68.59 (n)
(Gallus gallus)
Aves -- 34
  • 39 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 35 (a)
(Danio rerio)
Actinopterygii rnf128a 34
  • 35 (a)
si:dkeyp-86f7.4 34
  • 30 (a)
(Caenorhabditis elegans)
Secernentea H10E21.5 34
  • 15 (a)
Species where no ortholog for RNF133 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF133 Gene

Gene Tree for RNF133 (if available)
Gene Tree for RNF133 (if available)
Evolutionary constrained regions (ECRs) for RNF133: view image

Paralogs for RNF133 Gene

(5) SIMAP similar genes for RNF133 Gene using alignment to 1 proteins:

  • RN133_HUMAN
genes like me logo Genes that share paralogs with RNF133: view

Variants for RNF133 Gene

Sequence variations from dbSNP and Humsavar for RNF133 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000087056 -- 122,700,985(-) G/A upstream_transcript_variant
rs1001661032 -- 122,698,991(-) G/A 5_prime_UTR_variant
rs1003607926 -- 122,697,656(-) C/T downstream_transcript_variant
rs1004107593 -- 122,697,289(-) T/A/C/G downstream_transcript_variant
rs1004712669 -- 122,698,352(-) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF133 Gene

Variant ID Type Subtype PubMed ID
esv3891198 CNV gain 25118596

Variation tolerance for RNF133 Gene

Residual Variation Intolerance Score: 62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF133 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF133 Gene

Disorders for RNF133 Gene

Additional Disease Information for RNF133

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RNF133 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF133 Gene

Publications for RNF133 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  5. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X … REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology Donor Study-II Component International (PloS one 2013) 3 58

Products for RNF133 Gene

Sources for RNF133 Gene

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