Aliases for RNF13 Gene
External Ids for RNF13 Gene
Previous GeneCards Identifiers for RNF13 Gene
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Alternatively spliced transcript variants that encode the same protein have been reported. A pseudogene, which is also located on chromosome 3, has been defined for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNF13 Gene
RNF13 (Ring Finger Protein 13) is a Protein Coding gene. Diseases associated with RNF13 include Epileptic Encephalopathy, Early Infantile, 73 and Eccrine Porocarcinoma. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF167.
UniProtKB/Swiss-Prot Summary for RNF13 Gene
E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (PubMed:23378536, PubMed:30595371).