Aliases for RNF123 Gene
External Ids for RNF123 Gene
Previous GeneCards Identifiers for RNF123 Gene
The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
GeneCards Summary for RNF123 Gene
RNF123 (Ring Finger Protein 123) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is RSPRY1.
UniProtKB/Swiss-Prot for RNF123 Gene
Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.