The encoded protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The encoded protein is localized to the endoplasmic reticulum and golgi apparatus, and may be associated with cell viability. [provided by RefSeq, Jul 2013] See more...

Aliases for RNF122 Gene

Aliases for RNF122 Gene

  • Ring Finger Protein 122 2 3 5
  • RING Finger Protein 122 3 4

External Ids for RNF122 Gene

Previous GeneCards Identifiers for RNF122 Gene

  • GC08M033261
  • GC08M033462
  • GC08M033405
  • GC08M031937

Summaries for RNF122 Gene

Entrez Gene Summary for RNF122 Gene

  • The encoded protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The encoded protein is localized to the endoplasmic reticulum and golgi apparatus, and may be associated with cell viability. [provided by RefSeq, Jul 2013]

GeneCards Summary for RNF122 Gene

RNF122 (Ring Finger Protein 122) is a Protein Coding gene. Diseases associated with RNF122 include Attention Deficit-Hyperactivity Disorder. An important paralog of this gene is RNF24.

UniProtKB/Swiss-Prot Summary for RNF122 Gene

  • May induce necrosis and apoptosis. May play a role in cell viability.

Gene Wiki entry for RNF122 Gene

Additional gene information for RNF122 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF122 Gene

Genomics for RNF122 Gene

GeneHancer (GH) Regulatory Elements for RNF122 Gene


GeneHancers around RNF122 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF122

Top Transcription factor binding sites by QIAGEN in the RNF122 gene promoter:
  • AML1a
  • AP-4
  • COMP1
  • E4BP4
  • Egr-2
  • GCNF
  • GCNF-1
  • GCNF-2
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for RNF122 Gene

Genomic Locations for RNF122 Gene
chr8:33,547,754-33,567,128
(GRCh38/hg38)
Size:
19,375 bases
Orientation:
Minus strand
chr8:33,405,273-33,424,643
(GRCh37/hg19)
Size:
19,371 bases
Orientation:
Minus strand

Genomic View for RNF122 Gene

Genes around RNF122 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF122 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF122 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF122 Gene

Proteins for RNF122 Gene

  • Protein details for RNF122 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9V4-RN122_HUMAN
    Recommended name:
    RING finger protein 122
    Protein Accession:
    Q9H9V4
    Secondary Accessions:
    • Q52LK3

    Protein attributes for RNF122 Gene

    Size:
    155 amino acids
    Molecular mass:
    17475 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF122 Gene

Post-translational modifications for RNF122 Gene

  • Ubiquitination at Lys122
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF122 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF122 Gene

Domains & Families for RNF122 Gene

Gene Families for RNF122 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RNF122 Gene

Blocks:
  • Zn-finger, RING
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF122 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 122 (RN122_HUMAN)
genes like me logo Genes that share domains with RNF122: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RNF122 Gene

Function for RNF122 Gene

Molecular function for RNF122 Gene

UniProtKB/Swiss-Prot Function:
May induce necrosis and apoptosis. May play a role in cell viability.

Phenotypes From GWAS Catalog for RNF122 Gene

Gene Ontology (GO) - Molecular Function for RNF122 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20553626
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA,IMP 20553626
genes like me logo Genes that share ontologies with RNF122: view
genes like me logo Genes that share phenotypes with RNF122: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF122 Gene

Localization for RNF122 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF122 Gene

Golgi apparatus. Endoplasmic reticulum. Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF122 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 3
plasma membrane 2
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RNF122 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20553626
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0012505 endomembrane system IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RNF122: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNF122 Gene

Pathways & Interactions for RNF122 Gene

PathCards logo

SuperPathways for RNF122 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF122 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010917 negative regulation of mitochondrial membrane potential IDA 16751333
GO:0043065 positive regulation of apoptotic process IDA 16751333
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IMP 20553626
GO:0051865 protein autoubiquitination IMP 20553626
genes like me logo Genes that share ontologies with RNF122: view

No data available for Pathways by source and SIGNOR curated interactions for RNF122 Gene

Drugs & Compounds for RNF122 Gene

No Compound Related Data Available

Transcripts for RNF122 Gene

mRNA/cDNA for RNF122 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF122 Gene

No ASD Table

Relevant External Links for RNF122 Gene

GeneLoc Exon Structure for
RNF122

Expression for RNF122 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF122 Gene

mRNA differential expression in normal tissues according to GTEx for RNF122 Gene

This gene is overexpressed in Ovary (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF122

SOURCE GeneReport for Unigene cluster for RNF122 Gene:

Hs.151237

mRNA Expression by UniProt/SwissProt for RNF122 Gene:

Q9H9V4-RN122_HUMAN
Tissue specificity: Widely expressed in several tissues and cell lines.

Evidence on tissue expression from TISSUES for RNF122 Gene

  • Liver(4.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with RNF122: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF122 Gene

Orthologs for RNF122 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF122 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF122 31 30
  • 99.14 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RNF122 31 30
  • 92.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RNF122 31 30
  • 91.77 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF122 31
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf122 17 31 30
  • 89.39 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF122 31
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF122 31 30
  • 78.6 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF122 31
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii RNF122 31
  • 83 (a)
OneToOne
LOC100329730 30
  • 77.85 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 34 (a)
OneToMany
Species where no ortholog for RNF122 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF122 Gene

ENSEMBL:
Gene Tree for RNF122 (if available)
TreeFam:
Gene Tree for RNF122 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNF122: view image

Paralogs for RNF122 Gene

Paralogs for RNF122 Gene

(2) SIMAP similar genes for RNF122 Gene using alignment to 1 proteins:

  • RN122_HUMAN
genes like me logo Genes that share paralogs with RNF122: view

Variants for RNF122 Gene

Additional dbSNP identifiers (rs#s) for RNF122 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNF122 Gene

Variant ID Type Subtype PubMed ID
esv2666058 CNV deletion 23128226
esv2752251 CNV loss 17911159
esv3616836 CNV loss 21293372
nsv6146 CNV deletion 18451855

Variation tolerance for RNF122 Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF122 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF122

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNF122 Gene

Disorders for RNF122 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNF122 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
attention deficit-hyperactivity disorder
  • adhd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RNF122

genes like me logo Genes that share disorders with RNF122: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF122 Gene

Publications for RNF122 Gene

  1. Cell-based screening and validation of human novel genes associated with cell viability. (PMID: 16751333) Wang L … Ma D (Journal of biomolecular screening 2006) 3 4 54
  2. [Cloning, expression and subcellular localization of a novel human gene-RNF122]. (PMID: 16778963) Wang L … Wang L (Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 2006) 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Gene-wide Association Study Reveals RNF122 Ubiquitin Ligase as a Novel Susceptibility Gene for Attention Deficit Hyperactivity Disorder. (PMID: 28710364) Garcia-Martínez I … Ribasés M (Scientific reports 2017) 3 54

Products for RNF122 Gene

Sources for RNF122 Gene