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Aliases for RNF121 Gene

Aliases for RNF121 Gene

  • Ring Finger Protein 121 2 3 5
  • RING Finger Protein 121 3

External Ids for RNF121 Gene

Previous GeneCards Identifiers for RNF121 Gene

  • GC11P071862
  • GC11P071366
  • GC11P071317
  • GC11P071640
  • GC11P067933

Summaries for RNF121 Gene

Entrez Gene Summary for RNF121 Gene

  • The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products. [provided by RefSeq, Sep 2008]

GeneCards Summary for RNF121 Gene

RNF121 (Ring Finger Protein 121) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase activity. An important paralog of this gene is RNF175.

Additional gene information for RNF121 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF121 Gene

Genomics for RNF121 Gene

GeneHancer (GH) Regulatory Elements for RNF121 Gene

Promoters and enhancers for RNF121 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J071927 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 663.8 +1.1 1133 5.5 HDGF HNRNPUL1 PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 RNF121 LOC100133315 NUMA1 LOC100128494 ZNF705E IL18BP NADSYN1 FAM86C1 LOC220077 KRTAP5-13P
GH11J072430 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 51.3 +504.2 504226 4.7 ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 ZC3H11A ZNF610 ZNF585B CLPB NUMA1 LOC100128494 ZNF705E RNF121 IL18BP NADSYN1 FAM86C1 ENSG00000255672 ENSG00000256739
GH11J072098 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.1 +173.1 173108 6 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 LAMTOR1 FAM86C1 NUMA1 LOC100128494 LRTOMT ZNF705E RNF121 IL18BP OR7E128P ENSG00000204971
GH11J072077 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 +152.2 152158 5.9 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B YY1 NUMA1 LRTOMT ENSG00000284922 LOC100128494 FAM86C1 NADSYN1 IL18BP OR7E128P ZNF705E RNF121
GH11J072642 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 13.4 +714.3 714302 1.6 PKNOX1 CLOCK ATF1 SIN3A ZNF2 ETS1 GLIS2 ARID2 ZNF143 FOS LOC105369379 NUMA1 ZNF705E RNF121 LOC100128494 PDE2A GC11P072622
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF121 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF121 gene promoter:
  • FOXL1
  • c-Myb
  • AML1a
  • COMP1
  • Zic3
  • ISGF-3
  • IRF-2
  • E4BP4
  • CP2

Genomic Locations for RNF121 Gene

Genomic Locations for RNF121 Gene
68,897 bases
Plus strand
68,897 bases
Plus strand

Genomic View for RNF121 Gene

Genes around RNF121 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF121 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF121 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF121 Gene

Proteins for RNF121 Gene

  • Protein details for RNF121 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 121
    Protein Accession:
    Secondary Accessions:
    • B3KSW8
    • Q6IA57
    • Q6P449
    • Q96DB4

    Protein attributes for RNF121 Gene

    327 amino acids
    Molecular mass:
    37882 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH09672.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH63680.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF121 Gene


neXtProt entry for RNF121 Gene

Post-translational modifications for RNF121 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF121 Gene

Domains & Families for RNF121 Gene

Gene Families for RNF121 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RNF121 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RNF121 family.
  • Belongs to the RNF121 family.
genes like me logo Genes that share domains with RNF121: view

Function for RNF121 Gene

Gene Ontology (GO) - Molecular Function for RNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with RNF121: view
genes like me logo Genes that share phenotypes with RNF121: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF121 Gene

Localization for RNF121 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF121 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF121 gene
Compartment Confidence
endoplasmic reticulum 4
golgi apparatus 4
plasma membrane 3
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005789 endoplasmic reticulum membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF121: view

Pathways & Interactions for RNF121 Gene

SuperPathways for RNF121 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF121 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0030433 ubiquitin-dependent ERAD pathway IBA --
GO:0030968 endoplasmic reticulum unfolded protein response IBA --
genes like me logo Genes that share ontologies with RNF121: view

No data available for Pathways by source and SIGNOR curated interactions for RNF121 Gene

Drugs & Compounds for RNF121 Gene

No Compound Related Data Available

Transcripts for RNF121 Gene

Unigene Clusters for RNF121 Gene

Ring finger protein 121:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF121 Gene

No ASD Table

Relevant External Links for RNF121 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF121 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF121 Gene

Protein differential expression in normal tissues from HIPED for RNF121 Gene

This gene is overexpressed in Nasal epithelium (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF121 Gene

Protein tissue co-expression partners for RNF121 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF121 Gene:


SOURCE GeneReport for Unigene cluster for RNF121 Gene:


Evidence on tissue expression from TISSUES for RNF121 Gene

  • Nervous system(4.5)
  • Intestine(4.2)
  • Liver(4.2)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with RNF121: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF121 Gene

Orthologs for RNF121 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF121 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF121 34 33
  • 99.59 (n)
(Bos Taurus)
Mammalia RNF121 34 33
  • 94.33 (n)
(Canis familiaris)
Mammalia RNF121 34 33
  • 94.09 (n)
(Monodelphis domestica)
Mammalia RNF121 34
  • 93 (a)
(Rattus norvegicus)
Mammalia Rnf121 33
  • 91.85 (n)
(Mus musculus)
Mammalia Rnf121 16 34 33
  • 91.54 (n)
(Gallus gallus)
Aves RNF121 34 33
  • 84.51 (n)
(Anolis carolinensis)
Reptilia RNF121 34
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf121 33
  • 80.94 (n)
MGC75651 33
African clawed frog
(Xenopus laevis)
Amphibia MGC69129 33
(Danio rerio)
Actinopterygii rnf121 34 33
  • 73.6 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10586 33
fruit fly
(Drosophila melanogaster)
Insecta CG15814 34 33
  • 64.7 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008041 33
  • 62.05 (n)
(Caenorhabditis elegans)
Secernentea rnf-121 34 33
  • 57.11 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 64 (a)
Cin.8704 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8704 33
Species where no ortholog for RNF121 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF121 Gene

Gene Tree for RNF121 (if available)
Gene Tree for RNF121 (if available)
Evolutionary constrained regions (ECRs) for RNF121: view image

Paralogs for RNF121 Gene

Paralogs for RNF121 Gene

(3) SIMAP similar genes for RNF121 Gene using alignment to 11 proteins:

  • RN121_HUMAN
  • E9PN80_HUMAN
  • G3V148_HUMAN
genes like me logo Genes that share paralogs with RNF121: view

Variants for RNF121 Gene

Sequence variations from dbSNP and Humsavar for RNF121 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000023116 -- 71,972,914(+) C/T intron_variant
rs1000083082 -- 71,931,861(+) T/C intron_variant
rs1000098381 -- 71,979,779(+) A/C intron_variant
rs1000110727 -- 71,975,500(+) GGGGGG/GGGGG intron_variant
rs1000152911 -- 71,937,099(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF121 Gene

Variant ID Type Subtype PubMed ID
nsv509428 CNV insertion 20534489
nsv428262 CNV gain+loss 18775914
esv32752 CNV loss 17666407
esv2759836 CNV gain+loss 17122850

Variation tolerance for RNF121 Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF121 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF121 Gene

Disorders for RNF121 Gene

Additional Disease Information for RNF121

No disorders were found for RNF121 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF121 Gene

Publications for RNF121 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  5. RNF121 Inhibits Angiogenic Growth Factor Signaling by Restricting Cell Surface Expression of VEGFR-2. (PMID: 26602861) Maghsoudlou A … Rahimi N (Traffic (Copenhagen, Denmark) 2016) 3 58

Products for RNF121 Gene

Sources for RNF121 Gene

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