Aliases for RNF114 Gene

Aliases for RNF114 Gene

  • Ring Finger Protein 114 2 3 5
  • Zinc Finger Protein 313 2 3 4
  • RING-Type E3 Ubiquitin Transferase RNF114 3 4
  • E3 Ubiquitin-Protein Ligase RNF114 3 4
  • Zinc Finger Protein 228 3 4
  • ZNF313 3 4
  • RING Finger Protein 114 4
  • EC 2.3.2.27 4
  • PSORS12 3
  • ZNF228 4

External Ids for RNF114 Gene

Previous HGNC Symbols for RNF114 Gene

  • ZNF313

Previous GeneCards Identifiers for RNF114 Gene

  • GC20P047987
  • GC20P048552
  • GC20P045301

Summaries for RNF114 Gene

GeneCards Summary for RNF114 Gene

RNF114 (Ring Finger Protein 114) is a Protein Coding gene. Diseases associated with RNF114 include Psoriasis 12 and Inflammatory Bowel Disease 24. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is RNF166.

UniProtKB/Swiss-Prot Summary for RNF114 Gene

  • E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885). In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287). Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885). May promote the ubiquitination of TRAF6 as well (PubMed:28708287). Acts also as a negative regulator of T-cell activation (PubMed:25165885). Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885). Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206). This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis.

Additional gene information for RNF114 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF114 Gene

Genomics for RNF114 Gene

GeneHancer (GH) Regulatory Elements for RNF114 Gene

Promoters and enhancers for RNF114 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF114 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF114

Top Transcription factor binding sites by QIAGEN in the RNF114 gene promoter:
  • AML1a
  • AREB6
  • ATF-2
  • CREB
  • deltaCREB
  • GR
  • GR-alpha
  • Hlf
  • N-Myc

Genomic Locations for RNF114 Gene

Genomic Locations for RNF114 Gene
chr20:49,936,336-49,953,885
(GRCh38/hg38)
Size:
17,550 bases
Orientation:
Plus strand
chr20:48,552,914-48,570,429
(GRCh37/hg19)
Size:
17,516 bases
Orientation:
Plus strand

Genomic View for RNF114 Gene

Genes around RNF114 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF114 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF114 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF114 Gene

Proteins for RNF114 Gene

  • Protein details for RNF114 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y508-RN114_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF114
    Protein Accession:
    Q9Y508
    Secondary Accessions:
    • B2RDQ9
    • B4DWY5
    • E1P627
    • Q6N0B0

    Protein attributes for RNF114 Gene

    Size:
    228 amino acids
    Molecular mass:
    25694 Da
    Quaternary structure:
    • Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.
    SequenceCaution:
    • Sequence=CAE45709.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF114 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF114 Gene

Post-translational modifications for RNF114 Gene

  • Autoubiquitinated. Polyubiquitinated in the presence of E2 enzymes UBE2D1, UBE2D2 and UBE2D3, but only monoubiquitinated in the presence of UBE2E1.
  • Ubiquitination at Lys38, Lys61, Lys96, Lys102, Lys112, Lys122, Lys126, Lys149, Lys161, and Lys169
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF114 Gene

No data available for DME Specific Peptides for RNF114 Gene

Domains & Families for RNF114 Gene

Gene Families for RNF114 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for RNF114 Gene

Suggested Antigen Peptide Sequences for RNF114 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 313, isoform CRA_b (E1P628_HUMAN)
  • Zinc finger protein 313 (RN114_HUMAN)
genes like me logo Genes that share domains with RNF114: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RNF114 Gene

Function for RNF114 Gene

Molecular function for RNF114 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885). In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287). Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885). May promote the ubiquitination of TRAF6 as well (PubMed:28708287). Acts also as a negative regulator of T-cell activation (PubMed:25165885). Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885). Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206). This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=. ;.

Enzyme Numbers (IUBMB) for RNF114 Gene

Phenotypes From GWAS Catalog for RNF114 Gene

Gene Ontology (GO) - Molecular Function for RNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF114: view
genes like me logo Genes that share phenotypes with RNF114: view

Animal Model Products

CRISPR Products

miRNA for RNF114 Gene

miRTarBase miRNAs that target RNF114

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF114 Gene

Localization for RNF114 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF114 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF114 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
extracellular 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with RNF114: view

Pathways & Interactions for RNF114 Gene

genes like me logo Genes that share pathways with RNF114: view

UniProtKB/Swiss-Prot Q9Y508-RN114_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF114 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0016567 protein ubiquitination IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with RNF114: view

No data available for SIGNOR curated interactions for RNF114 Gene

Drugs & Compounds for RNF114 Gene

No Compound Related Data Available

Transcripts for RNF114 Gene

mRNA/cDNA for RNF114 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF114 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP5:
SP6:

Relevant External Links for RNF114 Gene

GeneLoc Exon Structure for
RNF114

Expression for RNF114 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF114 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF114 Gene

This gene is overexpressed in Testis (12.5), Peripheral blood mononuclear cells (9.2), and Breast (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF114 Gene



Protein tissue co-expression partners for RNF114 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF114

SOURCE GeneReport for Unigene cluster for RNF114 Gene:

Hs.144949

mRNA Expression by UniProt/SwissProt for RNF114 Gene:

Q9Y508-RN114_HUMAN
Tissue specificity: Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis.

Evidence on tissue expression from TISSUES for RNF114 Gene

  • Nervous system(4.9)
  • Lung(3.1)
  • Intestine(2.9)
  • Skin(2.6)
  • Eye(2.2)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with RNF114: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF114 Gene

Orthologs for RNF114 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF114 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF114 31 30
  • 99.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RNF114 31 30
  • 92.25 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RNF114 31 30
  • 90.12 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf114 17 31 30
  • 88.11 (n)
rat
(Rattus norvegicus)
Mammalia Rnf114 30
  • 87.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RNF114 31
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF114 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF114 31 30
  • 72.58 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF114 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf114 30
  • 63.03 (n)
Str.15724 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.16622 30
zebrafish
(Danio rerio)
Actinopterygii rnf114 31 30
  • 57.88 (n)
OneToOne
Species where no ortholog for RNF114 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF114 Gene

ENSEMBL:
Gene Tree for RNF114 (if available)
TreeFam:
Gene Tree for RNF114 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNF114: view image

Paralogs for RNF114 Gene

Paralogs for RNF114 Gene

(3) SIMAP similar genes for RNF114 Gene using alignment to 1 proteins:

  • RN114_HUMAN
genes like me logo Genes that share paralogs with RNF114: view

Variants for RNF114 Gene

Additional dbSNP identifiers (rs#s) for RNF114 Gene

Variation tolerance for RNF114 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF114 Gene

Human Gene Mutation Database (HGMD)
RNF114
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF114

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for RNF114 Gene

Disorders for RNF114 Gene

MalaCards: The human disease database

(6) MalaCards diseases for RNF114 Gene - From: OMIM and DISEASES

Disorder Aliases PubMed IDs
psoriasis 12
  • psoriasis 12, susceptibility to
inflammatory bowel disease 24
  • ibd24
inflammatory bowel disease 3
  • ibd3
inflammatory bowel disease 6
  • ibd6
inflammatory bowel disease 19
  • ibd19
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RNF114

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RNF114: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF114 Gene

Publications for RNF114 Gene

  1. Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. (PMID: 18364390) Capon F … Trembath RC (Human molecular genetics 2008) 2 3 4 54
  2. Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114. (PMID: 28625874) Lin B … Leaman DW (Cytokine 2017) 3 4 54
  3. The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation. (PMID: 25165885) Rodriguez MS … Lang V (Cell death & disease 2014) 3 4 54
  4. ZNF313 is a novel cell cycle activator with an E3 ligase activity inhibiting cellular senescence by destabilizing p21(WAF1.). (PMID: 23645206) Han J … Chi SG (Cell death and differentiation 2013) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for RNF114 Gene

Sources for RNF114 Gene