Aliases for RNF114 Gene
External Ids for RNF114 Gene
Previous HGNC Symbols for RNF114 Gene
Previous GeneCards Identifiers for RNF114 Gene
GeneCards Summary for RNF114 Gene
RNF114 (Ring Finger Protein 114) is a Protein Coding gene. Diseases associated with RNF114 include Psoriasis 12. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is RNF166.
UniProtKB/Swiss-Prot for RNF114 Gene
E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycles G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis.