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Aliases for RNF113B Gene

Aliases for RNF113B Gene

  • Ring Finger Protein 113B 2 3 5
  • Zinc Finger Protein 183-Like 1 2 3 4
  • ZNF183L1 3 4
  • RNF161 3 4
  • RING Finger Protein 113B 3
  • BA10G5.1 3

External Ids for RNF113B Gene

Previous HGNC Symbols for RNF113B Gene

  • ZNF183L1

Previous GeneCards Identifiers for RNF113B Gene

  • GC00U921548
  • GC13M097627
  • GC13M098828
  • GC13M079425

Summaries for RNF113B Gene

GeneCards Summary for RNF113B Gene

RNF113B (Ring Finger Protein 113B) is a Protein Coding gene. An important paralog of this gene is RNF113A.

Additional gene information for RNF113B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF113B Gene

Genomics for RNF113B Gene

GeneHancer (GH) Regulatory Elements for RNF113B Gene

Promoters and enhancers for RNF113B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J098177 Promoter 0.7 EPDnew 650.7 +0.0 1 0.1 L3MBTL2 GMEB1 MAFK PIR42956 RNF113B GC13M098177 FARP1
GH13J098141 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.3 +32.4 32435 5.8 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9 GLIS2 ZNF213 FARP1 LOC105370328 RNF113B STK24-AS1 GC13M098177 PIR42956
GH13J098170 Enhancer 1.4 FANTOM5 Ensembl ENCODE 14.1 +3.4 3419 5.9 PKNOX1 FOXA2 MLX ARID4B FEZF1 ZNF2 ZNF48 ETS1 YY1 GLIS2 RNF113B FARP1 PIR42956 GC13M098177 LOC105370328
GH13J098198 Enhancer 1 ENCODE dbSUPER 11.5 -22.8 -22837 2.9 SOX13 FOXA2 SAP130 CEBPG ZNF644 RBPJ RARA TEAD3 POLR2A NR2F6 RNF113B FARP1 RN7SKP8
GH13J098201 Enhancer 1 Ensembl ENCODE 11.5 -25.1 -25078 1.1 RAD21 RARA YY1 EGR1 RXRA ELF1 NR2F2 SP1 PRDM6 RCOR2 RN7SKP8 RNF113B FARP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF113B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF113B gene promoter:
  • POU2F1a
  • POU2F1
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2
  • STAT3
  • CUTL1
  • Ik-2
  • NRSF form 2

Genomic Locations for RNF113B Gene

Genomic Locations for RNF113B Gene
chr13:98,175,785-98,177,267
(GRCh38/hg38)
Size:
1,483 bases
Orientation:
Minus strand
chr13:98,828,039-98,829,521
(GRCh37/hg19)
Size:
1,483 bases
Orientation:
Minus strand

Genomic View for RNF113B Gene

Genes around RNF113B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF113B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF113B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF113B Gene

Proteins for RNF113B Gene

  • Protein details for RNF113B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZP6-R113B_HUMAN
    Recommended name:
    RING finger protein 113B
    Protein Accession:
    Q8IZP6
    Secondary Accessions:
    • Q8WWF9
    • Q96QY9

    Protein attributes for RNF113B Gene

    Size:
    322 amino acids
    Molecular mass:
    36259 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNF113B Gene

neXtProt entry for RNF113B Gene

Post-translational modifications for RNF113B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF113B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF113B Gene

Domains & Families for RNF113B Gene

Gene Families for RNF113B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RNF113B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF113B: view

No data available for UniProtKB/Swiss-Prot for RNF113B Gene

Function for RNF113B Gene

Phenotypes From GWAS Catalog for RNF113B Gene

Gene Ontology (GO) - Molecular Function for RNF113B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF113B: view
genes like me logo Genes that share phenotypes with RNF113B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF113B Gene

Localization for RNF113B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF113B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RNF113B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005684 U2-type spliceosomal complex IBA --
genes like me logo Genes that share ontologies with RNF113B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RNF113B Gene

Pathways & Interactions for RNF113B Gene

SuperPathways for RNF113B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF113B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034247 snoRNA splicing IBA --
GO:0045292 mRNA cis splicing, via spliceosome IBA --
genes like me logo Genes that share ontologies with RNF113B: view

No data available for Pathways by source and SIGNOR curated interactions for RNF113B Gene

Drugs & Compounds for RNF113B Gene

No Compound Related Data Available

Transcripts for RNF113B Gene

mRNA/cDNA for RNF113B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF113B Gene

Ring finger protein 113B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF113B Gene

No ASD Table

Relevant External Links for RNF113B Gene

GeneLoc Exon Structure for
RNF113B
ECgene alternative splicing isoforms for
RNF113B

Expression for RNF113B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF113B Gene

mRNA differential expression in normal tissues according to GTEx for RNF113B Gene

This gene is overexpressed in Testis (x51.0).

Protein differential expression in normal tissues from HIPED for RNF113B Gene

This gene is overexpressed in Heart (39.0) and Testis (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF113B Gene



Protein tissue co-expression partners for RNF113B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNF113B Gene:

RNF113B

SOURCE GeneReport for Unigene cluster for RNF113B Gene:

Hs.296045
genes like me logo Genes that share expression patterns with RNF113B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF113B Gene

Orthologs for RNF113B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF113B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF113B 34 33
  • 99.48 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf113a2 34
  • 66 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves RNF113A 34
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 59 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii rnf113a 34
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4973 34
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rnf-113 34
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CWC24 34
  • 29 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01954 33
  • 50 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToMany
Species where no ortholog for RNF113B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF113B Gene

ENSEMBL:
Gene Tree for RNF113B (if available)
TreeFam:
Gene Tree for RNF113B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNF113B: view image

Paralogs for RNF113B Gene

Paralogs for RNF113B Gene

(2) SIMAP similar genes for RNF113B Gene using alignment to 1 proteins:

  • R113B_HUMAN
genes like me logo Genes that share paralogs with RNF113B: view

Variants for RNF113B Gene

Sequence variations from dbSNP and Humsavar for RNF113B Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000721301 -- 98,177,587(-) T/C upstream_transcript_variant
rs1002496351 -- 98,175,821(-) G/A 3_prime_UTR_variant
rs1003170212 -- 98,178,884(-) A/G upstream_transcript_variant
rs1003229314 -- 98,179,080(-) T/C upstream_transcript_variant
rs1006035214 -- 98,177,889(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF113B Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER inversion 18451855
nsv1045047 CNV gain 25217958

Variation tolerance for RNF113B Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF113B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF113B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF113B Gene

Disorders for RNF113B Gene

Additional Disease Information for RNF113B

No disorders were found for RNF113B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF113B Gene

Publications for RNF113B Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  4. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein JI … Sullivan PF (Nature communications 2014) 3 58
  5. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PMID: 19549727) Markson G … Sanderson CM (Genome research 2009) 3 58

Products for RNF113B Gene

Sources for RNF113B Gene

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