Aliases for RNF112 Gene
External Ids for RNF112 Gene
Previous HGNC Symbols for RNF112 Gene
Previous GeneCards Identifiers for RNF112 Gene
This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNF112 Gene
RNF112 (Ring Finger Protein 112) is a Protein Coding gene. Diseases associated with RNF112 include Smith-Magenis Syndrome and Gummatous Syphilis. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is ATL1.
UniProtKB/Swiss-Prot Summary for RNF112 Gene
E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins (PubMed:28684796). Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (By similarity).