The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008] See more...

Aliases for RNF11 Gene

Aliases for RNF11 Gene

  • Ring Finger Protein 11 2 3 5
  • RING Finger Protein 11 3 4
  • CGI-123 3
  • SID1669 3

External Ids for RNF11 Gene

Previous GeneCards Identifiers for RNF11 Gene

  • GC01P051328
  • GC01P050590
  • GC01P051061
  • GC01P051071
  • GC01P051413
  • GC01P051474
  • GC01P051701
  • GC01P049819

Summaries for RNF11 Gene

Entrez Gene Summary for RNF11 Gene

  • The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF11 Gene

RNF11 (Ring Finger Protein 11) is a Protein Coding gene. Diseases associated with RNF11 include Parkinson Disease, Late-Onset. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is ZNRF1.

UniProtKB/Swiss-Prot Summary for RNF11 Gene

  • Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Gene Wiki entry for RNF11 Gene

Additional gene information for RNF11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF11 Gene

Genomics for RNF11 Gene

GeneHancer (GH) Regulatory Elements for RNF11 Gene

Promoters and enhancers for RNF11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J051234 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 513.7 +0.4 437 4.6 HNRNPK ZNF217 EP300 SIN3A NRF1 POLR2G BCLAF1 GTF2E2 PHF8 PHB2 RNF11 LINC01562 lnc-TTC39A-4 ENSG00000266993 CDKN2C OSBPL9
GH01J051728 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 12.2 +494.0 494038 4.2 HNRNPK ZBTB40 ZNF217 NRF1 USF1 POLR2G SP1 NCOR1 PHF8 ZIC2 OSBPL9 HSALNG0003587 ENSG00000266993 RNF11 PRPF38A NRDC TUT4 RNU6-877P piR-31937-003
GH01J050975 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 12.2 -258.4 -258363 5.4 NRF1 POLR2G GTF2E2 TEAD4 ZBTB5 ZIC2 REST ZBTB10 POLR2A ZBTB11 lnc-CDKN2C-1 lnc-FAF1-1 ENSG00000266993 RNF11 CDKN2C OSBPL9 DMRTA2
GH01J051267 Promoter/Enhancer 1 Ensembl ENCODE 11.7 +32.1 32138 2.4 EP300 FOS ARNT MEF2B SMARCA5 JUND EBF1 BMI1 ATF2 HDGF LINC01562 RNF11 ENSG00000233406 ENSG00000236434 HSALNG0003565
GH01J050931 Enhancer 0.8 Ensembl 12.2 -304.8 -304772 0.6 AFF1 HES1 TOE1 CTBP1 TRIM24 FOSL1 REPIN1 ZFHX2 MNT ZNF335 piR-36588-007 RNF11 CDKN2C FAF1 DMRTA2 piR-33432-010
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF11 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF11

Top Transcription factor binding sites by QIAGEN in the RNF11 gene promoter:
  • AP-2gamma
  • CREB
  • deltaCREB
  • Egr-1
  • Ik-1
  • Lmo2
  • S8
  • SRF
  • SRF (504 AA)
  • ZID

Genomic Locations for RNF11 Gene

Genomic Locations for RNF11 Gene
chr1:51,236,273-51,273,447
(GRCh38/hg38)
Size:
37,175 bases
Orientation:
Plus strand
chr1:51,701,943-51,739,127
(GRCh37/hg19)
Size:
37,185 bases
Orientation:
Plus strand

Genomic View for RNF11 Gene

Genes around RNF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF11 Gene

Proteins for RNF11 Gene

  • Protein details for RNF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3C5-RNF11_HUMAN
    Recommended name:
    RING finger protein 11
    Protein Accession:
    Q9Y3C5
    Secondary Accessions:
    • A8KAI2
    • Q5T7R8

    Protein attributes for RNF11 Gene

    Size:
    154 amino acids
    Molecular mass:
    17444 Da
    Quaternary structure:
    • Interacts (when phosphorylated) with 14-3-3. Interacts with the E3 ubiquitin-ligases NEDD4, ITCH, SMURF2 and WWP1 (By similarity). Also interacts with the E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2N, but neither with CDC34, nor with UBE2L3. Interacts with ZNF350, EPS15 and STAMBP. After TNF stimulation, interacts with TAX1BP1, TNFAIP3 and RIPK1; these interaction are transient and they are lost after 1 hour of stimulation with TNF (By similarity). Interacts with GGA1.

neXtProt entry for RNF11 Gene

Post-translational modifications for RNF11 Gene

  • Ubiquitinated in the presence of ITCH, or SMURF2, and UBE2D1, as well as WWP1.
  • Phosphorylation by PKB/AKT1 may accelerate degradation by the proteasome.
  • Acylation at both Gly-2 and Cys-4 is required for proper localization to the endosomes.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF11 Gene

Domains & Families for RNF11 Gene

Gene Families for RNF11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RNF11 Gene

Blocks:
  • Zn-finger, RING
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF11 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 11 (RNF11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y3C5

UniProtKB/Swiss-Prot:

RNF11_HUMAN :
  • The PPxY motif mediates interaction with NEDD4.
Domain:
  • The PPxY motif mediates interaction with NEDD4.
genes like me logo Genes that share domains with RNF11: view

Function for RNF11 Gene

Molecular function for RNF11 Gene

UniProtKB/Swiss-Prot Function:
Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Phenotypes From GWAS Catalog for RNF11 Gene

Gene Ontology (GO) - Molecular Function for RNF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 10673045
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0005515 protein binding IPI 14755250
GO:0008270 zinc ion binding TAS 10673045
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF11: view
genes like me logo Genes that share phenotypes with RNF11: view

Animal Model Products

CRISPR Products

miRNA for RNF11 Gene

miRTarBase miRNAs that target RNF11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF11 Gene

Localization for RNF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF11 Gene

Early endosome. Recycling endosome. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1. {ECO:0000269 PubMed:16123141}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF11 gene
Compartment Confidence
nucleus 5
endosome 5
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RNF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 14755250
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with RNF11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNF11 Gene

Pathways & Interactions for RNF11 Gene

PathCards logo

SuperPathways for RNF11 Gene

No Data Available

SIGNOR curated interactions for RNF11 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for RNF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IDA,IEA 14755250
GO:0051865 protein autoubiquitination IDA 24105792
genes like me logo Genes that share ontologies with RNF11: view

No data available for Pathways by source for RNF11 Gene

Drugs & Compounds for RNF11 Gene

No Compound Related Data Available

Transcripts for RNF11 Gene

mRNA/cDNA for RNF11 Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF11 Gene

No ASD Table

Relevant External Links for RNF11 Gene

GeneLoc Exon Structure for
RNF11

Expression for RNF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF11 Gene

This gene is overexpressed in Bone (50.5) and Fetal Brain (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF11 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF11

SOURCE GeneReport for Unigene cluster for RNF11 Gene:

Hs.309641

mRNA Expression by UniProt/SwissProt for RNF11 Gene:

Q9Y3C5-RNF11_HUMAN
Tissue specificity: Expressed at low levels in the lung, liver, kidney, pancreas, spleen, prostate, thymus, ovary, small intestine, colon, and peripheral blood lymphocytes, and, at intermediate levels, in the testis, heart, brain and placenta. Highest expression in the skeletal muscle. In the brain, expressed at different levels in several regions: high levels in the amygdala, moderate in the hippocampus and thalamus, low in the caudate and extremely low levels in the corpus callosum (at protein level). Restricted to neurons, enriched in somatodendritic compartments and excluded from white matter (at protein level). In substantia nigra, present in cell bodies and processes of dopaminergic and nondopaminergic cells (at protein level). In Parkinson disease, sequestered in Lewy bodies and neurites. Overexpressed in breast cancer cells, but not detected in the surrounding stroma and weakly, if at all, in normal breast epithelial cells (at protein level). Also expressed in several tumor cell lines.

Evidence on tissue expression from TISSUES for RNF11 Gene

  • Nervous system(4.9)
  • Liver(4.3)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with RNF11: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF11 Gene

Orthologs for RNF11 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF11 31 30
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF11 31
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RNF11 31 30
  • 97.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf11 17 31 30
  • 96.97 (n)
rat
(Rattus norvegicus)
Mammalia Rnf11l1 30
  • 95.45 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RNF11 31
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF11 31
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF11 31 30
  • 85.5 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF11 31
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf11 30
  • 83.33 (n)
zebrafish
(Danio rerio)
Actinopterygii rnf11b 31 30
  • 77.71 (n)
OneToOne
zgc63861 30
fruit fly
(Drosophila melanogaster)
Insecta CG32850 31 30
  • 54.25 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_C01G6.4 30
  • 49.3 (n)
C01G6.4 31
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 40 (a)
OneToOne
Species where no ortholog for RNF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF11 Gene

ENSEMBL:
Gene Tree for RNF11 (if available)
TreeFam:
Gene Tree for RNF11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNF11: view image

Paralogs for RNF11 Gene

Paralogs for RNF11 Gene

Pseudogenes.org Pseudogenes for RNF11 Gene

genes like me logo Genes that share paralogs with RNF11: view

Variants for RNF11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNF11 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs12077069 - p.Asp11Glu

Additional dbSNP identifiers (rs#s) for RNF11 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNF11 Gene

Variant ID Type Subtype PubMed ID
esv2663443 CNV deletion 23128226
esv3586031 CNV loss 21293372
esv3586032 CNV loss 21293372
nsv945940 CNV duplication 23825009

Variation tolerance for RNF11 Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF11 Gene

Disorders for RNF11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNF11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search RNF11 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RNF11

genes like me logo Genes that share disorders with RNF11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF11 Gene

Publications for RNF11 Gene

  1. Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein. (PMID: 10673045) Seki N … Saito T (Biochimica et biophysica acta 1999) 2 3 4 23 54
  2. The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11. (PMID: 18724389) Chen C … Seth AK (Oncogene 2008) 3 4 23 54
  3. PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain. (PMID: 17917589) Anderson LR … Levey AI (Journal of neuropathology and experimental neurology 2007) 3 4 23 54
  4. The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. (PMID: 14562029) Subramaniam V … Seth A (British journal of cancer 2003) 3 4 23 54
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 54

Products for RNF11 Gene

Sources for RNF11 Gene