The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008] See more...

Aliases for RNF10 Gene

Aliases for RNF10 Gene

  • Ring Finger Protein 10 2 3 5
  • RING Finger Protein 10 3 4
  • RIE2 3 4
  • Epididymis Secretory Sperm Binding Protein 3
  • KIAA0262 4

External Ids for RNF10 Gene

Previous GeneCards Identifiers for RNF10 Gene

  • GC12P119852
  • GC12P120755
  • GC12P119384
  • GC12P119434
  • GC12P120972
  • GC12P117981

Summaries for RNF10 Gene

Entrez Gene Summary for RNF10 Gene

  • The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF10 Gene

RNF10 (Ring Finger Protein 10) is a Protein Coding gene. Diseases associated with RNF10 include Charcot-Marie-Tooth Disease, Axonal, Type 2L. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot Summary for RNF10 Gene

  • Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.

Gene Wiki entry for RNF10 Gene

Additional gene information for RNF10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF10 Gene

Genomics for RNF10 Gene

GeneHancer (GH) Regulatory Elements for RNF10 Gene

Promoters and enhancers for RNF10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J120533 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 502.3 +3.8 3813 7.1 FOXK2 ZNF217 EP300 SIN3A NRF1 USF1 POLR2G GTF2E2 PHF8 JUND RNF10 COQ5 GATC RPL31P52 GCN1 CABP1 POP5 TRIAP1 ENSG00000111780 SPPL3
GH12J120494 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.6 -36.9 -36913 3.5 RXRA SIN3A NRF1 TCF12 POLR2G SP1 GTF2E2 PHF8 FOS ZFX DYNLL1 SRSF9 NRAV NONHSAG012519.2 COQ5 GATC RPL29P24 RPL31P52 GCN1 RNF10
GH12J120437 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 4.4 -94.8 -94780 3 ZBTB40 ZNF217 CTCF NRF1 POLR2G SP1 PHF8 ZFX POLR2A ZBTB11 COX6A1 ENSG00000111780 RF00004-033 COQ5 GATC RNF10
GH12J120498 Enhancer 0.7 Ensembl ENCODE 12.4 -34.1 -34116 0.9 POLR2G POLR2A RBM22 ZNF189 ZNF18 FEZF1 PAF1 ENSG00000278344 GATC RPL29P24 RNF10 COQ5 RPL31P52 TRIAP1 ENSG00000111780 COX6A1 NONHSAG012519.2
GH12J120223 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 3.6 -302.0 -301974 15.9 EP300 ZNF217 CTCF TCF12 MYC POLR2G USF1 NCOR1 JUND TEAD4 PXN SIRT4 RPLP0 RNU4-1 RNU4-2 PXN-AS1 PLA2G1B GCN1 RAB35 MSI1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF10

Top Transcription factor binding sites by QIAGEN in the RNF10 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • NF-Y
  • NF-YA
  • NF-YB

Genomic Locations for RNF10 Gene

Genomic Locations for RNF10 Gene
chr12:120,533,480-120,577,594
(GRCh38/hg38)
Size:
44,115 bases
Orientation:
Plus strand
chr12:120,971,283-121,015,397
(GRCh37/hg19)
Size:
44,115 bases
Orientation:
Plus strand

Genomic View for RNF10 Gene

Genes around RNF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF10 Gene

Proteins for RNF10 Gene

  • Protein details for RNF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5U6-RNF10_HUMAN
    Recommended name:
    RING finger protein 10
    Protein Accession:
    Q8N5U6
    Secondary Accessions:
    • Q92550
    • Q9NPP8
    • Q9ULW4

    Protein attributes for RNF10 Gene

    Size:
    811 amino acids
    Molecular mass:
    89927 Da
    Quaternary structure:
    • Interacts with MEOX2.

    Alternative splice isoforms for RNF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF10 Gene

Post-translational modifications for RNF10 Gene

  • Ubiquitination at Lys105, Lys136, Lys137, Lys167, Lys236, and Lys337
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF10 Gene

Domains & Families for RNF10 Gene

Gene Families for RNF10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RNF10 Gene

Blocks:
  • Zn-finger, RING
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF10 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 10 (RNF10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N5U6

UniProtKB/Swiss-Prot:

RNF10_HUMAN :
  • Belongs to the RNF10 family.
Family:
  • Belongs to the RNF10 family.
genes like me logo Genes that share domains with RNF10: view

Function for RNF10 Gene

Molecular function for RNF10 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination.

Phenotypes From GWAS Catalog for RNF10 Gene

Gene Ontology (GO) - Molecular Function for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0005515 protein binding IPI 16335786
GO:0044212 transcription regulatory region DNA binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF10: view
genes like me logo Genes that share phenotypes with RNF10: view

Animal Models for RNF10 Gene

MGI Knock Outs for RNF10:
  • Rnf10 Rnf10<tm1b(KOMP)Wtsi>
  • Rnf10 Rnf10<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF10

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF10 Gene

Localization for RNF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF10 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF10 gene
Compartment Confidence
nucleus 5
mitochondrion 2
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA,IEA 16335786
genes like me logo Genes that share ontologies with RNF10: view

Pathways & Interactions for RNF10 Gene

PathCards logo

SuperPathways for RNF10 Gene

No Data Available

SIGNOR curated interactions for RNF10 Gene

Activates:

Gene Ontology (GO) - Biological Process for RNF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010626 negative regulation of Schwann cell proliferation ISS --
GO:0031643 positive regulation of myelination ISS,IBA --
GO:0045893 positive regulation of transcription, DNA-templated IDA 16335786
GO:0045944 positive regulation of transcription by RNA polymerase II ISS --
GO:0051865 protein autoubiquitination IDA 24105792
genes like me logo Genes that share ontologies with RNF10: view

No data available for Pathways by source for RNF10 Gene

Drugs & Compounds for RNF10 Gene

No Compound Related Data Available

Transcripts for RNF10 Gene

mRNA/cDNA for RNF10 Gene

2 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
25 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF10

Alternative Splicing Database (ASD) splice patterns (SP) for RNF10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b ^ 11a ·
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7: - - -
SP8: - -
SP9: - - - -
SP10:
SP11:
SP12:
SP13: - -
SP14: - -
SP15: - -
SP16:
SP17:
SP18: - - - - - -

ExUns: 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4: - -
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13: - - -
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for RNF10 Gene

GeneLoc Exon Structure for
RNF10

Expression for RNF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF10 Gene

This gene is overexpressed in Whole Blood (x7.9).

Protein differential expression in normal tissues from HIPED for RNF10 Gene

This gene is overexpressed in Adipocyte (48.4) and Placenta (16.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF10 Gene



Protein tissue co-expression partners for RNF10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF10

SOURCE GeneReport for Unigene cluster for RNF10 Gene:

Hs.442798

Evidence on tissue expression from TISSUES for RNF10 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Eye(4.5)
  • Bone marrow(4.4)
  • Lung(3.9)
  • Kidney(3.7)
  • Intestine(3.4)
  • Skin(3.2)
  • Blood(2.9)
  • Spleen(2.7)
  • Heart(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with RNF10: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF10 Gene

Orthologs for RNF10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF10 31 30
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RNF10 30
  • 93.8 (n)
-- 31
  • 83 (a)
OneToMany
-- 31
  • 77 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RNF10 31 30
  • 93.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf10 17 31 30
  • 91.42 (n)
rat
(Rattus norvegicus)
Mammalia Rnf10 30
  • 91.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 79 (a)
OneToMany
-- 31
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RNF10 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF10 31 30
  • 75.11 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF10 31
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf10 30
  • 66.25 (n)
MGC75603 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.22040 30
zebrafish
(Danio rerio)
Actinopterygii rnf10 31 30
  • 63.37 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9616 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007954 30
  • 49.45 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12099 31 32 30
  • 47.79 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAG2 33 31
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4621 31
  • 36 (a)
OneToOne
Species where no ortholog for RNF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF10 Gene

ENSEMBL:
Gene Tree for RNF10 (if available)
TreeFam:
Gene Tree for RNF10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNF10: view image

Paralogs for RNF10 Gene

Pseudogenes.org Pseudogenes for RNF10 Gene

genes like me logo Genes that share paralogs with RNF10: view

No data available for Paralogs for RNF10 Gene

Variants for RNF10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNF10 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
727629 Likely Benign: not provided 120,546,580(+) T/C SYNONYMOUS_VARIANT
784474 Benign: not provided 120,562,975(+) G/A MISSENSE_VARIANT
rs16950277 - p.Glu433Asp
rs17852961 - p.Leu332Phe

Additional dbSNP identifiers (rs#s) for RNF10 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNF10 Gene

Variant ID Type Subtype PubMed ID
esv2746473 CNV deletion 23290073
esv3630927 CNV loss 21293372
nsv906 CNV deletion 18451855

Variation tolerance for RNF10 Gene

Residual Variation Intolerance Score: 3.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF10

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF10 Gene

Disorders for RNF10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNF10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, axonal, type 2l
  • cmt2l
- elite association - COSMIC cancer census association via MalaCards
Search RNF10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RNF10

genes like me logo Genes that share disorders with RNF10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF10 Gene

Publications for RNF10 Gene

  1. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PMID: 16335786) Lin J … Wigle JT (Molecular and cellular biochemistry 2005) 3 4 23 54
  2. cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein. (PMID: 10697961) Seki N … Saito T (Journal of human genetics 2000) 3 4 23 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 54
  5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T … Nomura N (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 3 4 54

Products for RNF10 Gene

Sources for RNF10 Gene