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This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
RND3 (Rho Family GTPase 3) is a Protein Coding gene. Diseases associated with RND3 include Cardiomyopathy, Familial Hypertrophic, 1. Among its related pathways are Phagocytosis of Microbes and RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RND2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 14732713 |
GO:0005525 | GTP binding | IEA,IBA | 21873635 |
GO:0019901 | protein kinase binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IEA | -- |
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0005856 | cytoskeleton | IBA | 21873635 |
GO:0005886 | plasma membrane | IBA | 21873635 |
GO:0005925 | focal adhesion | HDA | 21423176 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | G-AlphaQ Signaling |
G-AlphaI Signaling
.47
G-AlphaQ Signaling
.47
|
Thrombin Signaling
.40
|
2 | GPCR Pathway |
Ras Pathway
.73
GPCR Pathway
.62
|
Pancreatic Adenocarcinoma
.59
|
3 | ERK Signaling |
Rho Family GTPases
.61
Molecular Mechanisms of Cancer
.51
|
ILK Signaling
.49
|
4 | Actin Nucleation by ARP-WASP Complex |
Actin Nucleation and Branching
.66
|
Actin Nucleation by ARP-WASP Complex
.66
|
5 | Apoptotic Pathways in Synovial Fibroblasts |
Glioma Invasiveness
.64
|
Actin-Based Motility by Rho Family GTPases
.62
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007015 | actin filament organization | IBA | 21873635 |
GO:0007155 | cell adhesion | TAS | 9531558 |
GO:0007163 | establishment or maintenance of cell polarity | IBA | 21873635 |
GO:0007264 | small GTPase mediated signal transduction | IEA | -- |
GO:0008360 | regulation of cell shape | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Guanosine triphosphate | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RND3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RND3 31 |
|
OneToOne | |
LOC483917 30 |
|
||||
Oppossum (Monodelphis domestica) |
Mammalia | RND3 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RND3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rnd3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rnd3 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | RND3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RND3 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RND3 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rnd3 30 |
|
||
Str.17125 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.4080 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rnd3a 30 31 |
|
OneToMany | |
rnd3b 31 |
|
OneToMany | |||
idibd2919 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8918 30 |
|
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs111889908 | Benign: not provided | 150,470,170(-) |
A/G NM_001254738.1(RND3):c.552T>C (p.Asn184=) |
SYNONYMOUS | |
rs11885462 | Benign: not provided | 150,487,403(-) |
T/C NM_001254738.1(RND3):c.15A>G (p.Arg5=) |
SYNONYMOUS |
Disorder | Aliases | PubMed IDs |
---|---|---|
cardiomyopathy, familial hypertrophic, 1 |
|
|