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Aliases for RND3 Gene

Aliases for RND3 Gene

  • Rho Family GTPase 3 2 3 4 5
  • Rho-Related GTP-Binding Protein Rho8 3 4
  • Ras Homolog Gene Family, Member E 2 3
  • Protein MemB 3 4
  • ARHE 3 4
  • Rho-Related GTP-Binding Protein RhoE 3
  • Small GTP Binding Protein Rho8 3
  • Rho8 3
  • RhoE 3
  • MemB 3
  • RHO8 4
  • RHOE 4
  • Rnd3 4

External Ids for RND3 Gene

Previous HGNC Symbols for RND3 Gene

  • ARHE

Previous GeneCards Identifiers for RND3 Gene

  • GC02M151151
  • GC02M151032
  • GC02M151324
  • GC02M143221

Summaries for RND3 Gene

Entrez Gene Summary for RND3 Gene

  • This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for RND3 Gene

RND3 (Rho Family GTPase 3) is a Protein Coding gene. Among its related pathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RND2.

UniProtKB/Swiss-Prot for RND3 Gene

  • Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

Gene Wiki entry for RND3 Gene

Additional gene information for RND3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RND3 Gene

Genomics for RND3 Gene

GeneHancer (GH) Regulatory Elements for RND3 Gene

Promoters and enhancers for RND3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J150469 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 650.2 +60.0 59963 18.6 FOXA2 ZFP64 SIN3A ZNF2 YY1 ZNF143 FOS DEK SP3 REST RND3 LOC105373685
GH02J150538 Promoter/Enhancer 1.2 EPDnew ENCODE dbSUPER 650.7 0.0 0 1.3 CEBPB CREB1 ATF7 FOS ATF2 RND3 GC02M150536 LOC105373685
GH02J150525 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +10.7 10695 5.2 PKNOX1 SMAD1 NEUROD1 SIN3A BMI1 RAD21 RFX5 ATF7 FOS RCOR1 RND3 LOC105373685
GH02J150617 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 8.3 -81.4 -81374 5.1 JUN ZNF133 ZNF384 POLR2A ZNF366 SCRT2 NFE2 ATF7 FOSL2 FOS ENSG00000232359 RND3 TNFAIP6 GC02M150536 LOC101929282
GH02J150642 Enhancer 1 FANTOM5 ENCODE dbSUPER 5.7 -105.3 -105286 2.8 SP1 JUND POLR2A FOSL2 FOS FOXA1 RND3 TNFAIP6 GC02M150536 GC02P150679
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RND3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RND3 gene promoter:
  • p300
  • En-1
  • IRF-7A
  • PPAR-alpha
  • YY1
  • Arnt
  • Max1
  • AhR
  • USF2
  • USF1

Regulatory Element Products

Genomic Locations for RND3 Gene

Genomic Locations for RND3 Gene
70,819 bases
Minus strand
70,817 bases
Minus strand

Genomic View for RND3 Gene

Genes around RND3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RND3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RND3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RND3 Gene

Proteins for RND3 Gene

  • Protein details for RND3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho-related GTP-binding protein RhoE
    Protein Accession:
    Secondary Accessions:
    • D3DP95
    • P52199

    Protein attributes for RND3 Gene

    244 amino acids
    Molecular mass:
    27368 Da
    Quaternary structure:
    • Binds ROCK1 (By similarity). Interacts with UBXD5.

    Three dimensional structures from OCA and Proteopedia for RND3 Gene

neXtProt entry for RND3 Gene

Post-translational modifications for RND3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RND3 Gene

Antibody Products

  • Abcam antibodies for RND3
  • Boster Bio Antibodies for RND3

No data available for DME Specific Peptides for RND3 Gene

Domains & Families for RND3 Gene

Gene Families for RND3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RND3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rho family.
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RND3: view

Function for RND3 Gene

Molecular function for RND3 Gene

UniProtKB/Swiss-Prot Function:
Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

Gene Ontology (GO) - Molecular Function for RND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 23622247
GO:0005525 GTP binding IEA --
GO:0019901 protein kinase binding IBA --
genes like me logo Genes that share ontologies with RND3: view
genes like me logo Genes that share phenotypes with RND3: view

Animal Models for RND3 Gene

MGI Knock Outs for RND3:
  • Rnd3 Rnd3<tm1b(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for RND3

Clone Products

  • Addgene plasmids for RND3

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RND3 Gene

Localization for RND3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RND3 Gene

Golgi apparatus membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RND3 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytosol 3
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 COLOCALIZES_WITH plasma membrane IBA --
genes like me logo Genes that share ontologies with RND3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RND3 Gene

Pathways & Interactions for RND3 Gene

genes like me logo Genes that share pathways with RND3: view

SIGNOR curated interactions for RND3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IBA --
GO:0007155 cell adhesion TAS 9531558
GO:0007163 establishment or maintenance of cell polarity IBA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007266 Rho protein signal transduction IBA --
genes like me logo Genes that share ontologies with RND3: view

Drugs & Compounds for RND3 Gene

(3) Drugs for RND3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma Target 0

(2) Additional Compounds for RND3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RND3: view

Transcripts for RND3 Gene

mRNA/cDNA for RND3 Gene

Unigene Clusters for RND3 Gene

Rho family GTPase 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for RND3

Alternative Splicing Database (ASD) splice patterns (SP) for RND3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - -
SP3: -

Relevant External Links for RND3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RND3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RND3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RND3 Gene

This gene is overexpressed in Fetal Brain (28.5), Spleen (22.8), Prostate (9.6), and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RND3 Gene

Protein tissue co-expression partners for RND3 Gene

NURSA nuclear receptor signaling pathways regulating expression of RND3 Gene:


SOURCE GeneReport for Unigene cluster for RND3 Gene:


mRNA Expression by UniProt/SwissProt for RND3 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for RND3 Gene

  • Nervous system(4.7)
  • Kidney(4.4)
  • Spleen(4.4)
  • Skin(2.7)
  • Liver(2.6)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with RND3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RND3 Gene

Orthologs for RND3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RND3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RND3 34 33
  • 100 (n)
(Canis familiaris)
Mammalia RND3 34
  • 100 (a)
LOC483917 33
  • 89.48 (n)
(Monodelphis domestica)
Mammalia RND3 34
  • 98 (a)
(Bos Taurus)
Mammalia RND3 34 33
  • 93.58 (n)
(Mus musculus)
Mammalia Rnd3 16 34 33
  • 93.03 (n)
(Rattus norvegicus)
Mammalia Rnd3 33
  • 92.35 (n)
(Ornithorhynchus anatinus)
Mammalia RND3 34
  • 87 (a)
(Gallus gallus)
Aves RND3 34 33
  • 85.66 (n)
(Anolis carolinensis)
Reptilia RND3 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnd3 33
  • 81.69 (n)
Str.17125 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4080 33
(Danio rerio)
Actinopterygii rnd3a 34 33
  • 78.05 (n)
rnd3b 34
  • 78 (a)
idibd2919 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8918 33
Species where no ortholog for RND3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RND3 Gene

Gene Tree for RND3 (if available)
Gene Tree for RND3 (if available)
Evolutionary constrained regions (ECRs) for RND3: view image

Paralogs for RND3 Gene

Paralogs for RND3 Gene

(25) SIMAP similar genes for RND3 Gene using alignment to 4 proteins:

  • D3DP96_HUMAN
genes like me logo Genes that share paralogs with RND3: view

Variants for RND3 Gene

Sequence variations from dbSNP and Humsavar for RND3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000043471 -- 150,472,125(-) G/A intron_variant
rs1000158259 -- 150,472,174(-) T/C intron_variant
rs1000221682 -- 150,478,627(-) C/A intron_variant
rs1000267152 -- 150,478,870(-) G/A intron_variant
rs1000329829 -- 150,483,798(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RND3 Gene

Variant ID Type Subtype PubMed ID
nsv834414 CNV gain 17160897

Variation tolerance for RND3 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RND3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RND3 Gene

Disorders for RND3 Gene

Additional Disease Information for RND3

No disorders were found for RND3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RND3 Gene

Publications for RND3 Gene

  1. Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. (PMID: 8649376) Foster R … Settleman J (Molecular and cellular biology 1996) 2 3 4 22 58
  2. A genome-wide association search for type 2 diabetes genes in African Americans. (PMID: 22238593) Palmer ND … Sladek R (PloS one 2012) 3 44 58
  3. Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions. (PMID: 19244113) Klein RM … Aplin AE (Cancer research 2009) 3 22 58
  4. RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation. (PMID: 19850923) Villalonga P … Ridley AJ (The Journal of biological chemistry 2009) 3 22 58
  5. PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. (PMID: 18204440) Pinner S … Sahai E (Nature cell biology 2008) 3 22 58

Products for RND3 Gene

Sources for RND3 Gene

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