RND3 Gene (Protein Coding)

Rho Family GTPase 3

GC02M150468
GIFtS:
43
This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011] See more...

Aliases for RND3 Gene

Aliases for RND3 Gene

  • Rho Family GTPase 3 2 3 4 5
  • Rho-Related GTP-Binding Protein RhoE 3 4
  • Rho-Related GTP-Binding Protein Rho8 3 4
  • Ras Homolog Gene Family, Member E 2 3
  • Protein MemB 3 4
  • ARHE 3 4
  • Rho8 2 3
  • RhoE 2 3
  • Small GTP Binding Protein Rho8 3
  • MemB 3
  • RND3 5
  • RHO8 4
  • RHOE 4
  • Rnd3 4

External Ids for RND3 Gene

Previous HGNC Symbols for RND3 Gene

  • ARHE

Previous GeneCards Identifiers for RND3 Gene

  • GC02M151151
  • GC02M151032
  • GC02M151324
  • GC02M143221

Summaries for RND3 Gene

Entrez Gene Summary for RND3 Gene

  • This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

GeneCards Summary for RND3 Gene

RND3 (Rho Family GTPase 3) is a Protein Coding gene. Diseases associated with RND3 include Cardiomyopathy, Familial Hypertrophic, 1. Among its related pathways are G-AlphaQ Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RND2.

UniProtKB/Swiss-Prot Summary for RND3 Gene

  • Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

Gene Wiki entry for RND3 Gene

Additional gene information for RND3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RND3 Gene

Genomics for RND3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for RND3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J150469 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.2 +60.0 59963 18.6 ZNF654 JUND ZNF10 BRCA1 POLR2A ZIC2 ZBTB10 YY1 REST CEBPB RND3 HSALNG0019570 lnc-RBM43-6 MN297724 MMADHC
GH02J150538 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 250.7 0.0 0 1.3 ATF2 JUND BHLHE40 CEBPB FOS ATF7 CREB1 HSALNG0019572 RND3 HSALNG0019571 ENSG00000237220 MMADHC
GH02J150525 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 +9.3 9279 8.3 JUND BCL11A CEBPB NR2C1 ZNF217 EP300 CTBP1 MAFF RAD21 CUX1 RND3 HSALNG0019571 ENSG00000237220 MMADHC
GH02J150617 Enhancer 1.4 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.3 -84.1 -84075 10.6 JUND ATF2 CEBPB EP300 MAFF STAT3 TBP ZNF843 USF2 NFE2 RND3 TNFAIP6 ENSG00000232359 LINC02612 HSALNG0019576 piR-50852-073 LINC01920 RBM43
GH02J150642 Enhancer 1 FANTOM5 Ensembl ENCODE dbSUPER 5.7 -105.3 -105286 2.8 JUND FOXA1 POLR2A FOS RAD21 EP300 RND3 TNFAIP6 ENSG00000232359 piR-50852-073 LINC01920 RBM43
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RND3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RND3

Top Transcription factor binding sites by QIAGEN in the RND3 gene promoter:
  • AhR
  • Arnt
  • En-1
  • IRF-7A
  • Max1
  • p300
  • PPAR-alpha
  • USF1
  • USF2
  • YY1

Genomic Locations for RND3 Gene

Latest Assembly
chr2:150,468,193-150,539,011
(GRCh38/hg38)
Size:
70,819 bases
Orientation:
Minus strand

Previous Assembly
chr2:151,324,707-151,344,209
(GRCh37/hg19 by Entrez Gene)
Size:
19,503 bases
Orientation:
Minus strand

chr2:151,324,709-151,395,525
(GRCh37/hg19 by Ensembl)
Size:
70,817 bases
Orientation:
Minus strand

Genomic View for RND3 Gene

Genes around RND3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RND3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RND3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RND3 Gene

Proteins for RND3 Gene

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  • Protein details for RND3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61587-RND3_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoE
    Protein Accession:
    P61587
    Secondary Accessions:
    • D3DP95
    • P52199

    Protein attributes for RND3 Gene

    Size:
    244 amino acids
    Molecular mass:
    27368 Da
    Quaternary structure:
    • Binds ROCK1 (By similarity). Interacts with UBXD5.

    Three dimensional structures from OCA and Proteopedia for RND3 Gene

neXtProt entry for RND3 Gene

Protein Expression for RND3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RND3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RND3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for RND3
  • Boster Bio Antibodies for RND3

No data available for DME Specific Peptides for RND3 Gene

Domains & Families for RND3 Gene

Gene Families for RND3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RND3 Gene

InterPro:
Blocks:
  • Ras small GTPase, Ras type
  • Ras small GTPase, Rho type

Suggested Antigen Peptide Sequences for RND3 Gene

GenScript: Design optimal peptide antigens:
  • Rho family GTPase 3, isoform CRA_b (D3DP96_HUMAN)
  • ARHE protein (Q6FGN7_HUMAN)
  • ARHE protein (Q6FGR9_HUMAN)
  • Rnd3 (RND3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61587

UniProtKB/Swiss-Prot:

RND3_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RND3: view

Function for RND3 Gene

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  6. Cell Lines for research

Molecular function for RND3 Gene

UniProtKB/Swiss-Prot Function:
Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins.

Phenotypes From GWAS Catalog for RND3 Gene

Gene Ontology (GO) - Molecular Function for RND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA,IBA 21873635
GO:0005515 protein binding IPI 14732713
GO:0005525 GTP binding IEA,IBA 21873635
GO:0019901 protein kinase binding IBA 21873635
genes like me logo Genes that share ontologies with RND3: view
genes like me logo Genes that share phenotypes with RND3: view

Animal Models for RND3 Gene

MGI Knock Outs for RND3:
  • Rnd3 Rnd3<tm1b(EUCOMM)Hmgu>

Animal Models for research

  • Taconic Biosciences Mouse Models for RND3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RND3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RND3 Gene

Localization for RND3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RND3 Gene

Golgi apparatus membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RND3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
cytoskeleton 4
extracellular 3
cytosol 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for RND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005856 cytoskeleton IBA 21873635
GO:0005886 plasma membrane IBA 21873635
GO:0005925 focal adhesion HDA 21423176
genes like me logo Genes that share ontologies with RND3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RND3 Gene

Pathways & Interactions for RND3 Gene

PathCards logo

SuperPathways for RND3 Gene

SuperPathway Contained pathways
1 G-AlphaQ Signaling
G-AlphaI Signaling
.47
G-AlphaQ Signaling
.47
Thrombin Signaling
.40
2 GPCR Pathway
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
3 ERK Signaling
Rho Family GTPases
.61
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
4 Actin Nucleation by ARP-WASP Complex
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
5 Apoptotic Pathways in Synovial Fibroblasts
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
genes like me logo Genes that share pathways with RND3: view

Pathways by source for RND3 Gene

33 Qiagen pathways for RND3 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of PKC through GPCR
  • Antioxidant Action of Vitamin-C
1 Cell Signaling Technology pathway for RND3 Gene

SIGNOR curated interactions for RND3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RND3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IBA 21873635
GO:0007155 cell adhesion TAS 9531558
GO:0007163 establishment or maintenance of cell polarity IBA 21873635
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008360 regulation of cell shape IBA 21873635
genes like me logo Genes that share ontologies with RND3: view

Drugs & Compounds for RND3 Gene

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  1. Drug products for research

(3) Drugs for RND3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma Target 0

(2) Additional Compounds for RND3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RND3: view

Transcripts for RND3 Gene

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mRNA/cDNA for RND3 Gene

2 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RND3

Alternative Splicing Database (ASD) splice patterns (SP) for RND3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - -
SP2: - -
SP3: -
SP4:

Relevant External Links for RND3 Gene

GeneLoc Exon Structure for
RND3

Expression for RND3 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RND3 Gene

mRNA expression in normal human tissues for RND3 Gene
mRNA expression by BioGPS for RND3 GenemRNA expression by GTEx for RND3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RND3 Gene

This gene is overexpressed in Fetal Brain (28.5), Spleen (22.8), Prostate (9.6), and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RND3 Gene



Protein tissue co-expression partners for RND3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RND3

SOURCE GeneReport for Unigene cluster for RND3 Gene:

Hs.6838

mRNA Expression by UniProt/SwissProt for RND3 Gene:

P61587-RND3_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for RND3 Gene

  • Nervous system(4.8)
  • Spleen(4.6)
  • Kidney(4.5)
  • Skin(3.3)
  • Liver(3.1)
  • Heart(2.8)
  • Intestine(2.5)
  • Muscle(2.5)
  • Lung(2.4)
  • Adrenal gland(2.3)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with RND3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RND3 Gene

Orthologs for RND3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RND3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia RND3 29 30
  • 100 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia RND3 30
  • 100 (a)
 OneToOne
LOC483917 29
  • 89.48 (n)
Oppossum
(Monodelphis domestica)
 Mammalia RND3 30
  • 98 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia RND3 29 30
  • 93.58 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Rnd3 29 16 30
  • 93.03 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Rnd3 29
  • 92.35 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia RND3 30
  • 87 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves RND3 29 30
  • 85.66 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia RND3 30
  • 93 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia rnd3 29
  • 81.69 (n)
Str.17125 29
African clawed frog
(Xenopus laevis)
 Amphibia Xl.4080 29
Zebrafish
(Danio rerio)
 Actinopterygii rnd3a 29 30
  • 78.05 (n)
 OneToMany
rnd3b 30
  • 78 (a)
 OneToMany
idibd2919 29
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8918 29
Species where no ortholog for RND3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RND3 Gene

ENSEMBL:
Gene Tree for RND3 (if available)
TreeFam:
Gene Tree for RND3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RND3: view image
Alliance of Genome Resources:
Additional Orthologs for RND3

Paralogs for RND3 Gene

Paralogs for RND3 Gene

(25) SIMAP similar genes for RND3 Gene using alignment to 4 proteins:

  • RND3_HUMAN
  • D3DP96_HUMAN
  • E9PFH1_HUMAN
  • Q6FGN7_HUMAN
genes like me logo Genes that share paralogs with RND3: view

Variants for RND3 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RND3 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs111889908 Benign: not provided 150,470,170(-) A/G
NM_001254738.1(RND3):c.552T>C (p.Asn184=) 		SYNONYMOUS
rs11885462 Benign: not provided 150,487,403(-) T/C
NM_001254738.1(RND3):c.15A>G (p.Arg5=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RND3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RND3 Gene

Variant ID Type Subtype PubMed ID
nsv834414 CNV gain 17160897

Variation tolerance for RND3 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RND3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RND3
Leiden Open Variation Database (LOVD)
RND3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RND3 Gene

Disorders for RND3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RND3 Gene - From: COP

Disorder Aliases PubMed IDs
cardiomyopathy, familial hypertrophic, 1
  • cmh1
- elite association - COSMIC cancer census association via MalaCards
Search RND3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RND3

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RND3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RND3 Gene

Publications for RND3 Gene

  1. Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. (PMID: 8649376) Foster R … Settleman J (Molecular and cellular biology 1996) 2 3 4 22
  2. Pathophysiological Functions of Rnd3/RhoE. (PMID: 26756630) Jie W … Chang J (Comprehensive Physiology 2015) 2 3
  3. A genome-wide association search for type 2 diabetes genes in African Americans. (PMID: 22238593) Palmer ND … Sladek R (PloS one 2012) 3 40
  4. RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation. (PMID: 19850923) Villalonga P … Ridley AJ (The Journal of biological chemistry 2009) 3 22
  5. Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions. (PMID: 19244113) Klein RM … Aplin AE (Cancer research 2009) 3 22

ExternalLinks

View latest publications for RND3 gene in Mastermind

Products for RND3 Gene

  • Addgene plasmids for RND3

Sources for RND3 Gene