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Aliases for RND2 Gene

Aliases for RND2 Gene

  • Rho Family GTPase 2 2 3 4 5
  • Rho-Related GTP-Binding Protein Rho7 3 4
  • Ras Homolog Gene Family, Member N 2 3
  • ARHN 3 4
  • RHO7 3 4
  • Rho-Related GTP-Binding Protein RhoN 3
  • GTP-Binding Protein Rho7 3
  • CTD-3199J23.4 3
  • RhoN 3
  • Rnd2 4

External Ids for RND2 Gene

Previous HGNC Symbols for RND2 Gene

  • ARHN

Previous GeneCards Identifiers for RND2 Gene

  • GC17P038431
  • GC17P041177
  • GC17P036943
  • GC17P043027
  • GC17P043028
  • GC17P043098
  • GC17P043183
  • GC17P043199
  • GC17P043268
  • GC17P043331
  • GC17P043416

Summaries for RND2 Gene

Entrez Gene Summary for RND2 Gene

  • This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]

GeneCards Summary for RND2 Gene

RND2 (Rho Family GTPase 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include GTP binding and protein N-terminus binding. An important paralog of this gene is RND3.

UniProtKB/Swiss-Prot for RND2 Gene

  • May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).

Gene Wiki entry for RND2 Gene

Additional gene information for RND2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RND2 Gene

Genomics for RND2 Gene

GeneHancer (GH) Regulatory Elements for RND2 Gene

Promoters and enhancers for RND2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J043024 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.2 -202 2 HDGF CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF766 VAT1 RND2 NBR2 HMGN1P29 CCR10 ENSG00000267758 ENSG00000267002 LINC00910 DHX8 HSD17B1P1
GH17J043026 Enhancer 0.6 ENCODE dbSUPER 650.7 +1.7 1727 0.2 USF1 PRDM6 FEZF1 VAT1 RND2 GC17P043498
GH17J043124 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.1 +100.3 100340 2.8 MLX DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZC3H11A ZNF610 GLIS1 NBR2 PIR61659 PIR48082 NBR1 BRCA1 DHX8 HMGN1P29 ENSG00000267758 LINC00910 RETREG3
GH17J042386 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 -636.8 -636793 4.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 STAT3 GC17M042386 NBR1 ENSG00000267765 ENSG00000267002 KLHL10 HMGN1P29 ENSG00000267758 ENSG00000267340 TUBG2
GH17J042672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 -346.5 -346543 11.4 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 CNTNAP1 CCR10 PLEKHH3 ENSG00000267042 DHX8 TUBG2 HMGN1P29 ENSG00000267758 ENSG00000267002 ENSG00000266962
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RND2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RND2 gene promoter:
  • IRF-7A
  • N-Myc
  • RP58
  • Pax-4a
  • Lmo2
  • AP-1
  • MZF-1
  • SRF (504 AA)
  • SRF
  • ITF-2

Genomic Locations for RND2 Gene

Genomic Locations for RND2 Gene
chr17:43,025,241-43,032,041
(GRCh38/hg38)
Size:
6,801 bases
Orientation:
Plus strand
chr17:41,177,258-41,184,058
(GRCh37/hg19)
Size:
6,801 bases
Orientation:
Plus strand

Genomic View for RND2 Gene

Genes around RND2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RND2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RND2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RND2 Gene

Proteins for RND2 Gene

  • Protein details for RND2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52198-RND2_HUMAN
    Recommended name:
    Rho-related GTP-binding protein RhoN
    Protein Accession:
    P52198
    Secondary Accessions:
    • A8K2D4
    • O00690
    • O00734
    • Q5U0P6
    • Q99535

    Protein attributes for RND2 Gene

    Size:
    227 amino acids
    Molecular mass:
    25369 Da
    Quaternary structure:
    • Interacts with the Rho-GAP domain of RACGAP1. Interacts with UBXD5.

neXtProt entry for RND2 Gene

Post-translational modifications for RND2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RND2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RND2 Gene

Domains & Families for RND2 Gene

Gene Families for RND2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RND2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52198

UniProtKB/Swiss-Prot:

RND2_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RND2: view

Function for RND2 Gene

Molecular function for RND2 Gene

UniProtKB/Swiss-Prot Function:
May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).

Phenotypes From GWAS Catalog for RND2 Gene

Gene Ontology (GO) - Molecular Function for RND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,TAS --
GO:0005515 protein binding IPI 12590651
GO:0005525 GTP binding IEA --
GO:0019901 protein kinase binding IBA --
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with RND2: view
genes like me logo Genes that share phenotypes with RND2: view

Animal Model Products

Clone Products

  • Addgene plasmids for RND2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RND2 Gene

Localization for RND2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RND2 Gene

Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Lipid-anchor; Cytoplasmic side. Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome. {ECO:0000269 PubMed:12590651}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RND2 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
endosome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for RND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
GO:0005769 early endosome IEA --
GO:0005886 COLOCALIZES_WITH plasma membrane IBA --
genes like me logo Genes that share ontologies with RND2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RND2 Gene

Pathways & Interactions for RND2 Gene

genes like me logo Genes that share pathways with RND2: view

Gene Ontology (GO) - Biological Process for RND2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IBA --
GO:0007163 establishment or maintenance of cell polarity IBA --
GO:0007165 signal transduction TAS 8938427
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007266 Rho protein signal transduction IBA --
genes like me logo Genes that share ontologies with RND2: view

No data available for SIGNOR curated interactions for RND2 Gene

Drugs & Compounds for RND2 Gene

(1) Additional Compounds for RND2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RND2: view

Transcripts for RND2 Gene

mRNA/cDNA for RND2 Gene

Unigene Clusters for RND2 Gene

Rho family GTPase 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for RND2

Alternative Splicing Database (ASD) splice patterns (SP) for RND2 Gene

No ASD Table

Relevant External Links for RND2 Gene

GeneLoc Exon Structure for
RND2
ECgene alternative splicing isoforms for
RND2

Expression for RND2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RND2 Gene

mRNA differential expression in normal tissues according to GTEx for RND2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.4), Brain - Hypothalamus (x5.8), Brain - Substantia nigra (x5.8), Testis (x5.7), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for RND2 Gene

This gene is overexpressed in Spinal cord (40.4) and Testis (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RND2 Gene



Protein tissue co-expression partners for RND2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RND2 Gene:

RND2

SOURCE GeneReport for Unigene cluster for RND2 Gene:

Hs.603111

mRNA Expression by UniProt/SwissProt for RND2 Gene:

P52198-RND2_HUMAN
Tissue specificity: Highly expressed in testis.

Evidence on tissue expression from TISSUES for RND2 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with RND2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RND2 Gene

Orthologs for RND2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RND2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RND2 34 33
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RND2 34 33
  • 95.01 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RND2 34 33
  • 94.42 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnd2 33
  • 92.36 (n)
mouse
(Mus musculus)
Mammalia Rnd2 16 34 33
  • 92.22 (n)
oppossum
(Monodelphis domestica)
Mammalia RND2 34
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves RND2 34 33
  • 75.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RND2 34
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rnd2 34 33
  • 69.9 (n)
OneToOne
Species where no ortholog for RND2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RND2 Gene

ENSEMBL:
Gene Tree for RND2 (if available)
TreeFam:
Gene Tree for RND2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RND2: view image

Paralogs for RND2 Gene

Paralogs for RND2 Gene

(36) SIMAP similar genes for RND2 Gene using alignment to 2 proteins:

  • RND2_HUMAN
  • F5H2U5_HUMAN
genes like me logo Genes that share paralogs with RND2: view

Variants for RND2 Gene

Sequence variations from dbSNP and Humsavar for RND2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000135325 -- 43,031,175(+) A/T 3_prime_UTR_variant
rs1000165862 -- 43,027,009(+) C/T intron_variant
rs1000213974 -- 43,032,371(+) G/T downstream_transcript_variant
rs1000709241 -- 43,026,576(+) G/A intron_variant
rs1001004139 -- 43,025,189(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RND2 Gene

Variant ID Type Subtype PubMed ID
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159

Variation tolerance for RND2 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RND2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RND2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RND2 Gene

Disorders for RND2 Gene

Additional Disease Information for RND2

No disorders were found for RND2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RND2 Gene

Publications for RND2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching. (PMID: 14732713) Kakimoto T … Negishi M (The Journal of biological chemistry 2004) 3 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. (PMID: 12842009) Wennerberg K … Hansen SH (Current biology : CB 2003) 3 22 58
  5. Rho family GTPase Rnd2 interacts and co-localizes with MgcRacGAP in male germ cells. (PMID: 12590651) Naud N … Gacon G (The Biochemical journal 2003) 3 4 58

Products for RND2 Gene

Sources for RND2 Gene

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