This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014] See more...

Aliases for RND1 Gene

Aliases for RND1 Gene

  • Rho Family GTPase 1 2 3 4 5
  • Rho-Related GTP-Binding Protein Rho6 3 4
  • Ras Homolog Gene Family, Member S 2 3
  • ARHS 2 3
  • RHO6 3 4
  • RHOS 2 3
  • RND1 5
  • Rho6 2
  • Rnd1 4

External Ids for RND1 Gene

Previous GeneCards Identifiers for RND1 Gene

  • GC12M047537
  • GC12M049250
  • GC12M046283

Summaries for RND1 Gene

Entrez Gene Summary for RND1 Gene

  • This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014]

GeneCards Summary for RND1 Gene

RND1 (Rho Family GTPase 1) is a Protein Coding gene. Diseases associated with RND1 include Alcohol-Induced Mental Disorder and Alcoholic Psychosis. Among its related pathways are Axon guidance and Semaphorin Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RND3.

UniProtKB/Swiss-Prot Summary for RND1 Gene

  • Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.

Gene Wiki entry for RND1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RND1 Gene

Genomics for RND1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RND1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RND1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RND1

Top Transcription factor binding sites by QIAGEN in the RND1 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • Egr-4
  • NF-Y
  • NF-YA
  • NF-YB
  • POU2F1
  • POU2F1a

Genomic Locations for RND1 Gene

Genomic Locations for RND1 Gene
chr12:48,857,145-48,865,870
(GRCh38/hg38)
Size:
8,726 bases
Orientation:
Minus strand
chr12:49,250,916-49,259,681
(GRCh37/hg19)
Size:
8,766 bases
Orientation:
Minus strand

Genomic View for RND1 Gene

Genes around RND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RND1 Gene

Proteins for RND1 Gene

  • Protein details for RND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92730-RND1_HUMAN
    Recommended name:
    Rho-related GTP-binding protein Rho6
    Protein Accession:
    Q92730
    Secondary Accessions:
    • A8K9P7

    Protein attributes for RND1 Gene

    Size:
    232 amino acids
    Molecular mass:
    26056 Da
    Quaternary structure:
    • Binds GRB7 and PLXNB1. Interacts with UBXD5. Interacts with PLXNA2.

    Three dimensional structures from OCA and Proteopedia for RND1 Gene

neXtProt entry for RND1 Gene

Post-translational modifications for RND1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RND1 Gene

Domains & Families for RND1 Gene

Gene Families for RND1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RND1 Gene

InterPro:
Blocks:
  • Transforming protein P21 RAS signature
  • Ras small GTPase, Rho type
ProtoNet:

Suggested Antigen Peptide Sequences for RND1 Gene

GenScript: Design optimal peptide antigens:
  • Rnd1 (RND1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92730

UniProtKB/Swiss-Prot:

RND1_HUMAN :
  • Belongs to the small GTPase superfamily. Rho family.
Family:
  • Belongs to the small GTPase superfamily. Rho family.
genes like me logo Genes that share domains with RND1: view

Function for RND1 Gene

Molecular function for RND1 Gene

UniProtKB/Swiss-Prot Function:
Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.

Phenotypes From GWAS Catalog for RND1 Gene

Gene Ontology (GO) - Molecular Function for RND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IBA,NAS 9531558
GO:0005102 signaling receptor binding IPI 19843518
GO:0005515 protein binding IPI 10664463
GO:0005525 GTP binding IBA 21873635
genes like me logo Genes that share ontologies with RND1: view
genes like me logo Genes that share phenotypes with RND1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RND1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RND1 Gene

Localization for RND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RND1 Gene

Cell membrane. Lipid-anchor. Cytoplasmic side. Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RND1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
extracellular 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
  • Plasma membrane (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA,IBA 21873635
GO:0005886 plasma membrane IEA,IDA --
GO:0005912 adherens junction IDA 9531558
genes like me logo Genes that share ontologies with RND1: view

Pathways & Interactions for RND1 Gene

genes like me logo Genes that share pathways with RND1: view

Pathways by source for RND1 Gene

2 GeneGo (Thomson Reuters) pathways for RND1 Gene
  • Cell adhesion Ephrins signaling
  • Neurophysiological process Receptor-mediated axon growth repulsion
1 Qiagen pathway for RND1 Gene
  • Semaphorin Signaling

SIGNOR curated interactions for RND1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for RND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IBA,IDA 9531558
GO:0007162 negative regulation of cell adhesion IDA 9531558
GO:0007163 establishment or maintenance of cell polarity IBA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0007266 Rho protein signal transduction IBA --
genes like me logo Genes that share ontologies with RND1: view

Drugs & Compounds for RND1 Gene

(1) Drugs for RND1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for RND1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RND1: view

Transcripts for RND1 Gene

mRNA/cDNA for RND1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RND1

Alternative Splicing Database (ASD) splice patterns (SP) for RND1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3:

Relevant External Links for RND1 Gene

GeneLoc Exon Structure for
RND1

Expression for RND1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RND1 Gene

mRNA differential expression in normal tissues according to GTEx for RND1 Gene

This gene is overexpressed in Liver (x11.2), Brain - Cortex (x4.9), and Brain - Frontal Cortex (BA9) (x4.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RND1

SOURCE GeneReport for Unigene cluster for RND1 Gene:

Hs.124940

mRNA Expression by UniProt/SwissProt for RND1 Gene:

Q92730-RND1_HUMAN
Tissue specificity: Mostly expressed in brain and liver.

Evidence on tissue expression from TISSUES for RND1 Gene

  • Nervous system(4.8)
  • Lung(4.4)
  • Liver(2.7)
  • Skin(2.5)
  • Blood(2.3)
  • Intestine(2)
genes like me logo Genes that share expression patterns with RND1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RND1 Gene

Orthologs for RND1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RND1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RND1 30 31
  • 99.71 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RND1 30 31
  • 91.38 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rnd1 30
  • 90.95 (n)
Cow
(Bos Taurus)
Mammalia RND1 30 31
  • 90.52 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rnd1 30 17 31
  • 89.51 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RND1 31
  • 86 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rnd1 30
  • 73.71 (n)
Str.10750 30
African clawed frog
(Xenopus laevis)
Amphibia rho6-prov 30
Zebrafish
(Danio rerio)
Actinopterygii rnd1 31
  • 78 (a)
OneToMany
rnd1l 30 31
  • 75.86 (n)
OneToMany
Species where no ortholog for RND1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RND1 Gene

ENSEMBL:
Gene Tree for RND1 (if available)
TreeFam:
Gene Tree for RND1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RND1: view image

Paralogs for RND1 Gene

(21) SIMAP similar genes for RND1 Gene using alignment to 3 proteins:

  • RND1_HUMAN
  • F8VXU4_HUMAN
  • H0YHG7_HUMAN
genes like me logo Genes that share paralogs with RND1: view

Variants for RND1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RND1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
870981 Likely Benign: not provided 48,865,660(-) A/G SYNONYMOUS_VARIANT
rs2270577 - p.Pro44Arg

Additional dbSNP identifiers (rs#s) for RND1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RND1 Gene

Variant ID Type Subtype PubMed ID
nsv469373 CNV loss 19166990
nsv558832 CNV loss 21841781
nsv826363 CNV gain 20364138
nsv832404 CNV gain 17160897

Variation tolerance for RND1 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RND1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RND1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RND1 Gene

Disorders for RND1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RND1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alcohol-induced mental disorder
  • psychoses, alcoholic
alcoholic psychosis
  • alcoholic psychoses
mood disorder
  • episodic mood disorder
noonan syndrome 1
  • ns1
cardiomyopathy, familial hypertrophic, 1
  • fhc
- elite association - COSMIC cancer census association via MalaCards
Search RND1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with RND1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RND1 Gene

Publications for RND1 Gene

  1. A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. (PMID: 9531558) Nobes CD … Chardin P (The Journal of cell biology 1998) 2 3 4 23
  2. Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. (PMID: 12730235) Oinuma I … Negishi M (The Journal of biological chemistry 2003) 3 4 23
  3. Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family. (PMID: 10664463) Vayssière B … Camonis J (FEBS letters 2000) 3 4 23
  4. Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells. (PMID: 11095956) Aoki J … Negishi M (Biochemical and biophysical research communications 2000) 3 4 23
  5. Structure and function of the intracellular region of the plexin-b1 transmembrane receptor. (PMID: 19843518) Tong Y … Buck M (The Journal of biological chemistry 2009) 3 4

Products for RND1 Gene

  • Signalway Proteins for RND1

Sources for RND1 Gene