Aliases for RND1 Gene
External Ids for RND1 Gene
Previous GeneCards Identifiers for RND1 Gene
This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014]
GeneCards Summary for RND1 Gene
RND1 (Rho Family GTPase 1) is a Protein Coding gene. Diseases associated with RND1 include Mood Disorder and Cardiomyopathy, Familial Hypertrophic, 1. Among its related pathways are Semaphorin interactions and EPH-Ephrin signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RND3.
UniProtKB/Swiss-Prot Summary for RND1 Gene
Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.