Aliases for RNASEL Gene
External Ids for RNASEL Gene
Previous HGNC Symbols for RNASEL Gene
Previous GeneCards Identifiers for RNASEL Gene
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNASEL Gene
RNASEL (Ribonuclease L) is a Protein Coding gene. Diseases associated with RNASEL include Prostate Cancer, Hereditary, 1 and Chronic Fatigue Syndrome. Among its related pathways are Innate Immune System and Toll-like Receptor Signaling Pathway. Gene Ontology (GO) annotations related to this gene include RNA binding and protein kinase activity.
UniProtKB/Swiss-Prot Summary for RNASEL Gene
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.