This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008] See more...

Aliases for RNASEL Gene

Aliases for RNASEL Gene

  • Ribonuclease L 2 3 4 5
  • 2-5A-Dependent Ribonuclease 3 4
  • 2-5A-Dependent RNase 3 4
  • Ribonuclease 4 3 4
  • RNase L 3 4
  • RNS4 3 4
  • Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) 2
  • 2',5'-Oligoisoadenylate Synthetase-Dependent 3
  • Interferon-Induced 2-5A-Dependent RNase 3
  • Prostate Cancer 1 2
  • EC 3.1.26.- 4
  • RNASEL 5
  • PRCA1 3

External Ids for RNASEL Gene

Previous HGNC Symbols for RNASEL Gene

  • RNS4
  • PRCA1

Previous GeneCards Identifiers for RNASEL Gene

  • GC01M180070
  • GC01M177972
  • GC01M179063
  • GC01M179782
  • GC01M179274
  • GC01M180809
  • GC01M153780

Summaries for RNASEL Gene

Entrez Gene Summary for RNASEL Gene

  • This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNASEL Gene

RNASEL (Ribonuclease L) is a Protein Coding gene. Diseases associated with RNASEL include Prostate Cancer, Hereditary, 1 and Chronic Fatigue Syndrome. Among its related pathways are Interferon gamma signaling and Innate Immune System. Gene Ontology (GO) annotations related to this gene include RNA binding and protein kinase activity.

UniProtKB/Swiss-Prot Summary for RNASEL Gene

  • Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.

Gene Wiki entry for RNASEL Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNASEL Gene

Genomics for RNASEL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RNASEL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J182587 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 628.3 +0.5 484 2.4 CREB1 PRDM10 ZNF629 IKZF1 ZHX2 JUND ETV6 PRDM1 PKNOX1 POLR2A RNASEL DHX9 NPL ENSG00000276839 RGSL1
GH01J182600 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 23.1 -13.7 -13696 4 RNF2 GATAD2A CTCF PRDM10 KDM1A ZNF692 POLR2A BACH1 FOXA1 LARP7 RGS16 DHX9 RNASEL LAMC1-AS1 HMGN1P4 LAMC1 LAMC2 lnc-RGSL1-4
GH01J183469 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -882.6 -882569 4.3 BRCA1 ARHGAP35 SP1 CREB1 GATAD2A CTCF PRDM10 ZNF629 REST TFE3 SMG7 SMG7-AS1 DHX9 LAMC1-AS1 HMGN1P4 ENSG00000271387 LAMC1 RNASEL LAMC2 NCF2
GH01J182388 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.5 +198.5 198506 5.2 ZNF221 SP1 HNRNPL REST IKZF1 NFKBIZ ZNF692 POLR2A ZNF7 ZNF174 GLUL HSALNG0008912 DHX9 HMGN1P4 LAMC1-AS1 LINC01686 RNASEL LAMC2 TEDDM1 EIF1P3
GH01J182594 Enhancer 0.8 Ensembl ENCODE 21.4 -5.4 -5416 3 CTCF HNRNPL ZNF512 ZNF143 REST RAD21 TRIM22 ZNF561 SMC3 MYC lnc-RGSL1-4 RNASEL NPL RGSL1 DHX9 RGS16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNASEL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNASEL

Top Transcription factor binding sites by QIAGEN in the RNASEL gene promoter:
  • AhR
  • AP-1
  • AP-4
  • Arnt
  • ATF-2
  • c-Jun
  • ER-alpha
  • GATA-3
  • HNF-4alpha1

Genomic Locations for RNASEL Gene

Genomic Locations for RNASEL Gene
chr1:182,573,634-182,589,285
(GRCh38/hg38)
Size:
15,652 bases
Orientation:
Minus strand
chr1:182,542,769-182,558,394
(GRCh37/hg19)
Size:
15,626 bases
Orientation:
Minus strand

Genomic View for RNASEL Gene

Genes around RNASEL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASEL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASEL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASEL Gene

Proteins for RNASEL Gene

  • Protein details for RNASEL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05823-RN5A_HUMAN
    Recommended name:
    2-5A-dependent ribonuclease
    Protein Accession:
    Q05823
    Secondary Accessions:
    • Q5W0L2
    • Q6AI46

    Protein attributes for RNASEL Gene

    Size:
    741 amino acids
    Molecular mass:
    83533 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer (inactive form) or homodimer. Interacts with ABCE1; this interaction inhibits the RNASEL.

    Three dimensional structures from OCA and Proteopedia for RNASEL Gene

    Alternative splice isoforms for RNASEL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNASEL Gene

Post-translational modifications for RNASEL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNASEL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNASEL Gene

Domains & Families for RNASEL Gene

Gene Families for RNASEL Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RNASEL Gene

Suggested Antigen Peptide Sequences for RNASEL Gene

GenScript: Design optimal peptide antigens:
  • Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) (Q1RLL8_HUMAN)
  • Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) (Q5W0L2_HUMAN)
  • Ribonuclease L (RN5A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q05823

UniProtKB/Swiss-Prot:

RN5A_HUMAN :
  • The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain.
  • Belongs to the protein kinase superfamily.
Domain:
  • The nine ankyrin repeats also called 2-5A sensor constitute the N-terminus 2-5A binding domain.
  • The protein kinase domain is predicted to be catalytically inactive. It allows the homodimerization.
  • The ribonuclease domain is located in the C-terminus. A single active nuclease domain in a dimer is sufficient for ribonuclease activity (By similarity).
Family:
  • Belongs to the protein kinase superfamily.
genes like me logo Genes that share domains with RNASEL: view

Function for RNASEL Gene

Molecular function for RNASEL Gene

UniProtKB/Swiss-Prot Function:
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.
UniProtKB/Swiss-Prot Induction:
By interferons. Virus replication in higher vertebrates is restrained by IFNs that cause cells to transcribe genes encoding antiviral proteins, such as 2'-5' oligoadenylate synthetases (OASs). oligoadenylate synthetase is stimulated by dsRNA to produce 5'-phosphorylated, 2'-5'-linked oligoadenylates (2-5A), whose function is to activate RNASEL.
UniProtKB/Swiss-Prot EnzymeRegulation:
After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and subsequent activation occurs. Inhibited by RNASEL inhibitor ABCE1/RLI, a cytoplasmic member of the ATP-binding cassette (ABC) transporter family.
GENATLAS Biochemistry:
ribonuclease L,2',5'-oligoisoadenylate dependent,interferon regulated pathway

Enzyme Numbers (IUBMB) for RNASEL Gene

Phenotypes From GWAS Catalog for RNASEL Gene

Gene Ontology (GO) - Molecular Function for RNASEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding IEA,IDA 7514601
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004521 endoribonuclease activity NAS 7514601
genes like me logo Genes that share ontologies with RNASEL: view
genes like me logo Genes that share phenotypes with RNASEL: view

Human Phenotype Ontology for RNASEL Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for RNASEL Gene

MGI Knock Outs for RNASEL:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASEL

No data available for Transcription Factor Targets and HOMER Transcription for RNASEL Gene

Localization for RNASEL Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASEL Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASEL gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 4
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RNASEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with RNASEL: view

Pathways & Interactions for RNASEL Gene

genes like me logo Genes that share pathways with RNASEL: view

Pathways by source for RNASEL Gene

SIGNOR curated interactions for RNASEL Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RNASEL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IEA --
GO:0006396 RNA processing IBA 21873635
GO:0006397 mRNA processing IEA --
GO:0006468 protein phosphorylation NAS 7514601
GO:0043488 regulation of mRNA stability IEA --
genes like me logo Genes that share ontologies with RNASEL: view

Drugs & Compounds for RNASEL Gene

(12) Drugs for RNASEL Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Manganese Approved Nutra 56

(13) Additional Compounds for RNASEL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RNASEL: view

Transcripts for RNASEL Gene

mRNA/cDNA for RNASEL Gene

1 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASEL

Alternative Splicing Database (ASD) splice patterns (SP) for RNASEL Gene

No ASD Table

Relevant External Links for RNASEL Gene

GeneLoc Exon Structure for
RNASEL

Expression for RNASEL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNASEL Gene

mRNA differential expression in normal tissues according to GTEx for RNASEL Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for RNASEL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.5) and Cervix (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNASEL Gene



Protein tissue co-expression partners for RNASEL Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNASEL

SOURCE GeneReport for Unigene cluster for RNASEL Gene:

Hs.518545

mRNA Expression by UniProt/SwissProt for RNASEL Gene:

Q05823-RN5A_HUMAN
Tissue specificity: Highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for RNASEL Gene

  • Kidney(4.5)
  • Blood(2.7)
  • Spleen(2.7)
  • Lymph node(2.5)
  • Lung(2.4)
  • Liver(2.3)
  • Intestine(2.3)
  • Nervous system(2.3)
  • Skin(2.2)
  • Heart(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASEL Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • reproductive
Regions:
Head and neck:
  • brain
  • cerebellum
  • head
Pelvis:
  • prostate
General:
  • spinal cord
genes like me logo Genes that share expression patterns with RNASEL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RNASEL Gene

Orthologs for RNASEL Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASEL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RNASEL 30 31
  • 98.74 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RNASEL 30 31
  • 80.45 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RNASEL 30 31
  • 80.09 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rnasel 30 17 31
  • 72.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rnasel 30
  • 72.82 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia RNASEL 31
  • 56 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RNASEL 31
  • 53 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RNASEL 30 31
  • 55 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RNASEL 31
  • 44 (a)
OneToOne
Species where no ortholog for RNASEL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RNASEL Gene

ENSEMBL:
Gene Tree for RNASEL (if available)
TreeFam:
Gene Tree for RNASEL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNASEL: view image

Paralogs for RNASEL Gene

(1) SIMAP similar genes for RNASEL Gene using alignment to 2 proteins:

  • RN5A_HUMAN
  • Q1RLL8_HUMAN
genes like me logo Genes that share paralogs with RNASEL: view

No data available for Paralogs for RNASEL Gene

Variants for RNASEL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNASEL Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
716675 Conflicting Interpretations: not provided 182,586,453(-) G/A SYNONYMOUS_VARIANT
720340 Benign: not provided 182,585,565(-) G/A SYNONYMOUS_VARIANT
774801 Conflicting Interpretations: not provided 182,585,628(-) C/T SYNONYMOUS_VARIANT
774802 Likely Benign: not provided 182,586,632(-) C/T MISSENSE_VARIANT
775629 Benign: not provided 182,586,468(-) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for RNASEL Gene

Structural Variations from Database of Genomic Variants (DGV) for RNASEL Gene

Variant ID Type Subtype PubMed ID
esv1010175 CNV deletion 20482838
esv3588104 CNV loss 21293372
nsv548358 CNV gain 21841781
nsv825531 CNV loss 20364138
nsv825564 CNV loss 20364138

Variation tolerance for RNASEL Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.78; 86.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASEL Gene

Human Gene Mutation Database (HGMD)
RNASEL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASEL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASEL Gene

Disorders for RNASEL Gene

MalaCards: The human disease database

(18) MalaCards diseases for RNASEL Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RN5A_HUMAN
  • Prostate cancer, hereditary, 1 (HPC1) [MIM:601518]: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000305 PubMed:11799394, ECO:0000305 PubMed:11941539, ECO:0000305 PubMed:12415269, ECO:0000305 PubMed:17344846}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for RNASEL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RNASEL: view

No data available for Genatlas for RNASEL Gene

Publications for RNASEL Gene

  1. Germline alterations of the RNASEL gene, a candidate HPC1 gene at 1q25, in patients and families with prostate cancer. (PMID: 11941539) Rökman A … Schleutker J (American journal of human genetics 2002) 3 4 23 41
  2. Single and multivariate associations of MSR1, ELAC2, and RNASEL with prostate cancer in an ethnic diverse cohort of men. (PMID: 20086112) Beuten J … Leach RJ (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 23 41
  3. Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II. (PMID: 19267370) Wang MH … Platz EA (The Prostate 2009) 3 23 41
  4. Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. (PMID: 19760027) Tsilidis KK … Platz EA (Cancer causes & control : CCC 2009) 3 23 41
  5. Analysis of the RNASEL/HPC1, and macrophage scavenger receptor 1 in Asian-Indian advanced prostate cancer. (PMID: 18436282) Rennert H … Rebbeck TR (Urology 2008) 3 23 41

Products for RNASEL Gene

  • Signalway ELISA kits for RNASEL
  • Signalway Proteins for RNASEL

Sources for RNASEL Gene