Aliases for RNASEK Gene

Aliases for RNASEK Gene

  • Ribonuclease K 2 3 5
  • Ribonuclease, RNase K 2 3
  • Ribonuclease Kappa 3 4
  • RNase Kappa 3 4
  • RNase Kappa-02 Isoform 3
  • EC 3.1.-.- 4
  • MGC71993 2
  • RNase K 4
  • RNASEK 5

External Ids for RNASEK Gene

Previous GeneCards Identifiers for RNASEK Gene

  • GC17P006862
  • GC17P006863
  • GC17P006915

Summaries for RNASEK Gene

GeneCards Summary for RNASEK Gene

RNASEK (Ribonuclease K) is a Protein Coding gene. Diseases associated with RNASEK include Rift Valley Fever. Gene Ontology (GO) annotations related to this gene include endoribonuclease activity.

UniProtKB/Swiss-Prot Summary for RNASEK Gene

  • Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate.
  • (Microbial infection) Required for the initial stages of clathrin-mediated endocytic uptake of a diverse set of viruses, including dengue, West Nile, Sindbis, Rift Valley Fever, and influenza viruses (PubMed:26056282). Not required for clathrin-mediated endocytosis and macropinocytosis (PubMed:26056282).

Additional gene information for RNASEK Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNASEK Gene

Genomics for RNASEK Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RNASEK Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNASEK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNASEK

Top Transcription factor binding sites by QIAGEN in the RNASEK gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • Nkx2-5
  • POU3F2
  • Sox9
  • Spz1

Genomic Locations for RNASEK Gene

Genomic Locations for RNASEK Gene
chr17:7,012,417-7,014,533
(GRCh38/hg38)
Size:
2,117 bases
Orientation:
Plus strand
chr17:6,915,736-6,917,852
(GRCh37/hg19)
Size:
2,117 bases
Orientation:
Plus strand

Genomic View for RNASEK Gene

Genes around RNASEK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASEK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASEK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASEK Gene

Proteins for RNASEK Gene

  • Protein details for RNASEK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P5S7-RNK_HUMAN
    Recommended name:
    Ribonuclease kappa
    Protein Accession:
    Q6P5S7
    Secondary Accessions:
    • G3V1Z9
    • Q502Z2

    Protein attributes for RNASEK Gene

    Size:
    137 amino acids
    Molecular mass:
    15420 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH51802.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH62705.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAF82619.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAN89245.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for RNASEK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNASEK Gene

Post-translational modifications for RNASEK Gene

  • Ubiquitination at Lys132
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNASEK Gene

Domains & Families for RNASEK Gene

Gene Families for RNASEK Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for RNASEK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RNASEK Gene

GenScript: Design optimal peptide antigens:
  • RNASEK protein (Q502Z2_HUMAN)
  • Ribonuclease kappa (RNK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P5S7

UniProtKB/Swiss-Prot:

RNK_HUMAN :
  • Belongs to the RNase K family.
Family:
  • Belongs to the RNase K family.
genes like me logo Genes that share domains with RNASEK: view

Function for RNASEK Gene

Molecular function for RNASEK Gene

UniProtKB/Swiss-Prot Function:
Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Required for the initial stages of clathrin-mediated endocytic uptake of a diverse set of viruses, including dengue, West Nile, Sindbis, Rift Valley Fever, and influenza viruses (PubMed:26056282). Not required for clathrin-mediated endocytosis and macropinocytosis (PubMed:26056282).

Enzyme Numbers (IUBMB) for RNASEK Gene

Phenotypes From GWAS Catalog for RNASEK Gene

Gene Ontology (GO) - Molecular Function for RNASEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004521 endoribonuclease activity IEA,IDA 17881363
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RNASEK: view
genes like me logo Genes that share phenotypes with RNASEK: view

Animal Models for RNASEK Gene

MGI Knock Outs for RNASEK:
  • Rnasek Rnasek<tm1b(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for RNASEK

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASEK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNASEK Gene

Localization for RNASEK Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASEK Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASEK gene
Compartment Confidence
plasma membrane 1
endosome 1
extracellular 0

Gene Ontology (GO) - Cellular Components for RNASEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNASEK: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASEK Gene

Pathways & Interactions for RNASEK Gene

PathCards logo

SuperPathways for RNASEK Gene

No Data Available

Interacting Proteins for RNASEK Gene

Gene Ontology (GO) - Biological Process for RNASEK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RNASEK: view

No data available for Pathways by source and SIGNOR curated interactions for RNASEK Gene

Drugs & Compounds for RNASEK Gene

No Compound Related Data Available

Transcripts for RNASEK Gene

mRNA/cDNA for RNASEK Gene

1 REFSEQ mRNAs :
31 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASEK

Alternative Splicing Database (ASD) splice patterns (SP) for RNASEK Gene

No ASD Table

Relevant External Links for RNASEK Gene

GeneLoc Exon Structure for
RNASEK

Expression for RNASEK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNASEK Gene

mRNA differential expression in normal tissues according to GTEx for RNASEK Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for RNASEK Gene

This gene is overexpressed in Retina (41.6) and Pancreas (16.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASEK Gene



Protein tissue co-expression partners for RNASEK Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNASEK

SOURCE GeneReport for Unigene cluster for RNASEK Gene:

Hs.632232

mRNA Expression by UniProt/SwissProt for RNASEK Gene:

Q6P5S7-RNK_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for RNASEK Gene

  • Nervous system(4.7)
  • Adrenal gland(4.4)
  • Pancreas(2.7)
  • Kidney(2.4)
  • Muscle(2.4)
  • Spleen(2)
  • Lymph node(2)
  • Heart(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with RNASEK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASEK Gene

Orthologs for RNASEK Gene

This gene was present in the common ancestor of animals.

Orthologs for RNASEK Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RNASEK 30 31
  • 100 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm21988 31
  • 100 (a)
OneToMany
Rnasek 30 17 31
  • 94.56 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia RNASEK 30 31
  • 95.58 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rnasek 30
  • 94.22 (n)
Dog
(Canis familiaris)
Mammalia RNASEK 30 31
  • 94.22 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RNASEK 31
  • 75 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RNASEK 31
  • 48 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100493134 30
  • 78.57 (n)
Zebrafish
(Danio rerio)
Actinopterygii rnasekb 30 31
  • 69.76 (n)
OneToMany
rnaseka 31
  • 68 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG40127 31
  • 38 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3620 31
  • 39 (a)
OneToOne
Species where no ortholog for RNASEK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RNASEK Gene

ENSEMBL:
Gene Tree for RNASEK (if available)
TreeFam:
Gene Tree for RNASEK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNASEK: view image

Paralogs for RNASEK Gene

(1) SIMAP similar genes for RNASEK Gene using alignment to 6 proteins:

  • RNK_HUMAN
  • F8W1G5_HUMAN
  • H0YHM1_HUMAN
  • H0YIM4_HUMAN
  • H0YIU3_HUMAN
  • I3L285_HUMAN
genes like me logo Genes that share paralogs with RNASEK: view

No data available for Paralogs for RNASEK Gene

Variants for RNASEK Gene

Additional dbSNP identifiers (rs#s) for RNASEK Gene

Structural Variations from Database of Genomic Variants (DGV) for RNASEK Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952117 CNV deletion 24416366

Variation tolerance for RNASEK Gene

Residual Variation Intolerance Score: 75.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASEK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASEK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNASEK Gene

Disorders for RNASEK Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNASEK Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rift valley fever
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RNASEK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RNASEK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASEK Gene

Publications for RNASEK Gene

  1. Molecular cloning and characterization of the human RNase kappa, an ortholog of Cc RNase. (PMID: 17881363) Economopoulou MA … Sideris DC (Nucleic acids research 2007) 2 3 4
  2. RNASEK Is a V-ATPase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus. (PMID: 26212330) Perreira JM … Brass AL (Cell reports 2015) 2 3
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Expressional profiling and clinical relevance of RNase κ in prostate cancer: a novel indicator of favorable progression-free survival. (PMID: 30054827) Kladi-Skandali A … Sideris DC (Journal of cancer research and clinical oncology 2018) 3

Products for RNASEK Gene

Sources for RNASEK Gene