Aliases for RNASE9 Gene

Aliases for RNASE9 Gene

  • Ribonuclease A Family Member 9 (Inactive) 2 3 5
  • Ribonuclease, RNase A Family, 9 (Non-Active) 2 3
  • Inactive Ribonuclease-Like Protein 9 3 4
  • RAK1 2 3
  • H461 2 3
  • Ribonuclear Enzyme 3
  • Ribonuclease A K1 3
  • HEL128 3
  • RNASE9 5

External Ids for RNASE9 Gene

Previous GeneCards Identifiers for RNASE9 Gene

  • GC14M020096
  • GC14M021024
  • GC14M001145

Summaries for RNASE9 Gene

GeneCards Summary for RNASE9 Gene

RNASE9 (Ribonuclease A Family Member 9 (Inactive)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE11.

UniProtKB/Swiss-Prot Summary for RNASE9 Gene

Additional gene information for RNASE9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNASE9 Gene

Genomics for RNASE9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RNASE9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020559 Enhancer 0.4 ENCODE 600.7 +1.4 1369 0.9 SCRT2 SCRT1 NANOG POU5F1 RNASE9 SETP1 RNASE10
GH14J020560 Enhancer 0.3 Ensembl 600.7 -0.1 -70 0.4 USF1 RNASE9 piR-50357-053 RNASE12
GH14J020605 Enhancer 1 Ensembl ENCODE 11.6 -45.5 -45498 1.2 GATAD2A CTCF TFE3 IKZF1 ZNF7 RXRB REST RAD21 SP1 SOX6 RNASE9 RNA5SP382 TEP1 SNORD126 CCNB1IP1 ENSG00000259060 TRP-AGG2-5 RNASE11 lnc-RNASE12-1 HE855982-002
GH14J020582 Enhancer 0.4 Ensembl 11.4 -23.2 -23170 3.4 NFE2 POLR2A MYC POU5F1 RNASE11 RNASE9 RNASE10 RNA5SP382 TEP1 PNP PIP4P1 OR5AU1 piR-41306-072 RNASE12
GH14J020603 Enhancer 0.4 Ensembl 11.7 -43.4 -43370 2.2 SCRT2 POLR2A ATF4 RNASE9 RNA5SP382 TEP1 SNORD126 CCNB1IP1 ENSG00000259060 RNASE11 HE855982-002 TRP-AGG2-5 lnc-RNASE12-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNASE9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNASE9

Top Transcription factor binding sites by QIAGEN in the RNASE9 gene promoter:
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • NF-Y
  • NF-YA
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for RNASE9 Gene

Genomic Locations for RNASE9 Gene
4,839 bases
Minus strand
4,839 bases
Minus strand

Genomic View for RNASE9 Gene

Genes around RNASE9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE9 Gene

Proteins for RNASE9 Gene

  • Protein details for RNASE9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive ribonuclease-like protein 9
    Protein Accession:
    Secondary Accessions:
    • A2RQR8
    • A8QJS1
    • Q5GAN7
    • Q6KG53

    Protein attributes for RNASE9 Gene

    205 amino acids
    Molecular mass:
    24307 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNASE9 Gene


neXtProt entry for RNASE9 Gene

Post-translational modifications for RNASE9 Gene

  • Glycosylation at Asn131 and Asn143
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNASE9 Gene

Domains & Families for RNASE9 Gene

Gene Families for RNASE9 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RNASE9 Gene

Suggested Antigen Peptide Sequences for RNASE9 Gene

GenScript: Design optimal peptide antigens:
  • RNase 9 (A2RQR8_HUMAN)
  • RNASE9 variant alpha23' (A8QJS1_HUMAN)
  • Ribonuclease, RNase A family, 9 (Non-active) (Q6KG53_HUMAN)
  • Ribonuclease-like protein 9 (RNAS9_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pancreatic ribonuclease family.
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE9: view

Function for RNASE9 Gene

Molecular function for RNASE9 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit any ribonuclease activity.

Phenotypes From GWAS Catalog for RNASE9 Gene

Gene Ontology (GO) - Molecular Function for RNASE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004540 NOT ribonuclease activity IBA,IKR 15676279
genes like me logo Genes that share ontologies with RNASE9: view
genes like me logo Genes that share phenotypes with RNASE9: view

Animal Models for RNASE9 Gene

MGI Knock Outs for RNASE9:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE9

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE9 Gene

Localization for RNASE9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE9 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE9 gene
Compartment Confidence
extracellular 4
plasma membrane 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RNASE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE9 Gene

Pathways & Interactions for RNASE9 Gene

PathCards logo

SuperPathways for RNASE9 Gene

No Data Available

Interacting Proteins for RNASE9 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000384683 P60153-RNAS9_HUMAN for RNASE9 Gene via STRING IID

Gene Ontology (GO) - Biological Process for RNASE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with RNASE9: view

No data available for Pathways by source and SIGNOR curated interactions for RNASE9 Gene

Drugs & Compounds for RNASE9 Gene

No Compound Related Data Available

Transcripts for RNASE9 Gene

mRNA/cDNA for RNASE9 Gene

15 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE9

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE9 Gene

No ASD Table

Relevant External Links for RNASE9 Gene

GeneLoc Exon Structure for

Expression for RNASE9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNASE9 Gene

Protein differential expression in normal tissues from HIPED for RNASE9 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE9 Gene

Protein tissue co-expression partners for RNASE9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNASE9

SOURCE GeneReport for Unigene cluster for RNASE9 Gene:


mRNA Expression by UniProt/SwissProt for RNASE9 Gene:

Tissue specificity: At the mRNA level, widely expressed (PubMed:18992174). At protein level, restricted to epididymis (PubMed:19137000). Expressed in spermatozoa (sperm head and neck), with higher levels on ejaculated and epididymal sperm than on testicular sperm (at protein level). Expressed in the epithelial cells of the epididymal tubule (at protein level). Not detected in muscle.

Evidence on tissue expression from TISSUES for RNASE9 Gene

  • Nervous system(3.8)
  • Lung(3.4)
  • Intestine(3.3)
  • Muscle(3.1)
  • Pancreas(3.1)
  • Heart(2.4)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with RNASE9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE9 Gene

Orthologs for RNASE9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNASE9 30 31
  • 97.4 (n)
(Rattus norvegicus)
Mammalia Rnase9 30
  • 56.43 (n)
(Mus musculus)
Mammalia Rnase9 30 17 31
  • 55.95 (n)
(Canis familiaris)
Mammalia RNASE9 31
  • 45 (a)
(Bos Taurus)
Mammalia RNASE9 31
  • 41 (a)
Species where no ortholog for RNASE9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RNASE9 Gene

Gene Tree for RNASE9 (if available)
Gene Tree for RNASE9 (if available)
Evolutionary constrained regions (ECRs) for RNASE9: view image

Paralogs for RNASE9 Gene

genes like me logo Genes that share paralogs with RNASE9: view

Variants for RNASE9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNASE9 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs1243647 - p.Ser204Pro
rs12590446 - p.Phe148Ser

Additional dbSNP identifiers (rs#s) for RNASE9 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNASE9 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545

Variation tolerance for RNASE9 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASE9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE9 Gene

Disorders for RNASE9 Gene

Additional Disease Information for RNASE9

No disorders were found for RNASE9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE9 Gene

Publications for RNASE9 Gene

  1. Cloning, expression and location of RNase9 in human epididymis. (PMID: 18992174) Liu J … Wang W (BMC research notes 2008) 3 4 23
  2. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S … Zhang J (Genomics 2005) 2 3 4
  3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S … Sun J (Carcinogenesis 2012) 3 41
  4. Human ribonuclease 9, a member of ribonuclease A superfamily, specifically expressed in epididymis, is a novel sperm-binding protein. (PMID: 19137000) Cheng GZ … Shi GX (Asian journal of andrology 2009) 4 23
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4

Products for RNASE9 Gene

Sources for RNASE9 Gene