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RNASE9 Gene(Protein Coding)

Ribonuclease A Family Member 9 (Inactive)

GCID:
GC14M020556
GIFtS:
36
Genes Participants
UDN Logo

Aliases for RNASE9 Gene

Aliases for RNASE9 Gene

  • Ribonuclease A Family Member 9 (Inactive) 2 3 5
  • Ribonuclease, RNase A Family, 9 (Non-Active) 2 3
  • Inactive Ribonuclease-Like Protein 9 3
  • Ribonuclear Enzyme 3
  • Ribonuclease A K1 3
  • HEL128 3
  • RAK1 3
  • H461 3

External Ids for RNASE9 Gene

Previous GeneCards Identifiers for RNASE9 Gene

  • GC14M020096
  • GC14M021024
  • GC14M001145

Summaries for RNASE9 Gene

GeneCards Summary for RNASE9 Gene

RNASE9 (Ribonuclease A Family Member 9 (Inactive)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity.

UniProtKB/Swiss-Prot for RNASE9 Gene

  • Does not exhibit any ribonuclease activity.

Additional gene information for RNASE9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE9 Gene

Genomics for RNASE9 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for RNASE9 Gene

Promoters and enhancers for RNASE9 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH14I020559 Enhancer 0.4 ENCODE 550.8 +1.4 1369 0.9 SCRT1 SCRT2 POU5F1 RNASE9 SETP1
GH14I020605 Enhancer 0.8 ENCODE 11.6 -45.5 -45498 1.2 ELF3 FOXA2 SIN3A RAD21 RARA ETS1 ZNF143 MIXL1 HMG20B ZNF654 RNASE9 RNA5SP382 TEP1 SNORD126 CCNB1IP1 RNASE11 TRP-AGG2-5 ENSG00000259060 LOC254028 RNASE12
GH14I020601 Enhancer 0.4 Ensembl 11.6 -41.0 -40970 0.2 STAT1 REST RNASE9 RNA5SP382 TEP1 SNORD126 CCNB1IP1 ENSG00000259060 TRP-AGG2-5 RNASE11 LOC254028 RNASE12
GH14I020591 Enhancer 0.3 FANTOM5 7.5 -30.9 -30940 0.1 IKZF1 RNASE12 OR4K17 OR6S1 OR11H6 OR4N5 OR11H4 RNASE8 EDDM3B RNASE9 RNASE13
GH14I020531 Enhancer 0.8 ENCODE 0.3 +29.8 29764 0.2 HDAC1 FOXA2 ZNF2 RAD21 GATA2 ZNF366 ZNF143 ETV6 ZNF654 ZNF114 LINC00641 SETP1 RNASE9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNASE9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNASE9 gene promoter:

Genomic Locations for RNASE9 Gene

Genomic Locations for RNASE9 Gene
chr14:20,556,093-20,560,931
(GRCh38/hg38)
Size:
4,839 bases
Orientation:
Minus strand
chr14:21,024,252-21,029,090
(GRCh37/hg19)

Genomic View for RNASE9 Gene

Genes around RNASE9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE9 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RNASE9 Gene

Proteins for RNASE9 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RNASE9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60153-RNAS9_HUMAN
    Recommended name:
    Inactive ribonuclease-like protein 9
    Protein Accession:
    P60153
    Secondary Accessions:
    • A2RQR8
    • A8QJS1
    • Q5GAN7
    • Q6KG53

    Protein attributes for RNASE9 Gene

    Size:
    205 amino acids
    Molecular mass:
    24307 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNASE9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNASE9 Gene

Protein Expression for RNASE9 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RNASE9 Gene

  • Glycosylation at Asn131 and isoforms=2143
  • Modification sites at PhosphoSitePlus

Other Protein References for RNASE9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNASE9 Gene

Domains & Families for RNASE9 Gene

Gene Families for RNASE9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RNASE9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RNASE9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60153

UniProtKB/Swiss-Prot:

RNAS9_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE9: view

Function for RNASE9 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for RNASE9 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit any ribonuclease activity.

Phenotypes From GWAS Catalog for RNASE9 Gene

Gene Ontology (GO) - Molecular Function for RNASE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004519 endonuclease activity IBA --
GO:0004540 NOT ribonuclease activity IKR 15676279
genes like me logo Genes that share ontologies with RNASE9: view
genes like me logo Genes that share phenotypes with RNASE9: view

Animal Models for RNASE9 Gene

MGI Knock Outs for RNASE9:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE9 Gene

Localization for RNASE9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE9 gene
Compartment Confidence
extracellular 4
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for RNASE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE9 Gene

Pathways & Interactions for RNASE9 Gene

SuperPathways for RNASE9 Gene

PathCards logo More details on SuperPathways for RNASE9
No Data Available

Interacting Proteins for RNASE9 Gene

Selected Interacting proteins: P60153-RNAS9_HUMAN for RNASE9 Gene via IID

Symbol External ID(s) Details
TPST2

Gene Ontology (GO) - Biological Process for RNASE9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with RNASE9: view

No data available for Pathways by source and SIGNOR curated interactions for RNASE9 Gene

Drugs & Compounds for RNASE9 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for RNASE9 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for RNASE9 Gene

(8) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE9 Gene

No ASD Table

Relevant External Links for RNASE9 Gene

GeneLoc Exon Structure for
RNASE9
ECgene alternative splicing isoforms for
RNASE9

Expression for RNASE9 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNASE9 Gene

mRNA expression in normal human tissues for RNASE9 Gene
mRNA expression by GTEx for RNASE9 Gene

Protein differential expression in normal tissues from HIPED for RNASE9 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE9 Gene



Protein tissue co-expression partners for RNASE9 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNASE9 Gene:

RNASE9

SOURCE GeneReport for Unigene cluster for RNASE9 Gene:

Hs.533972

mRNA Expression by UniProt/SwissProt for RNASE9 Gene:

P60153-RNAS9_HUMAN
Tissue specificity: At the mRNA level, widely expressed (PubMed:18992174). At protein level, restricted to epididymis (PubMed:19137000). Expressed in spermatozoa (sperm head and neck), with higher levels on ejaculated and epididymal sperm than on testicular sperm (at protein level). Expressed in the epithelial cells of the epididymal tubule (at protein level). Not detected in muscle.

Evidence on tissue expression from TISSUES for RNASE9 Gene

  • Nervous system(3.8)
  • Lung(3.4)
  • Intestine(3.3)
  • Muscle(3.1)
  • Pancreas(3.1)
  • Heart(2.4)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with RNASE9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE9 Gene

Orthologs for RNASE9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia RNASE9 33 34
  • 97.4 (n)
rat
(Rattus norvegicus)
 Mammalia Rnase9 33
  • 56.43 (n)
mouse
(Mus musculus)
 Mammalia Rnase9 33 16 34
  • 55.95 (n)
dog
(Canis familiaris)
 Mammalia RNASE9 34
  • 45 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia RNASE9 34
  • 41 (a)
 OneToOne
Species where no ortholog for RNASE9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE9 Gene

ENSEMBL:
Gene Tree for RNASE9 (if available)
TreeFam:
Gene Tree for RNASE9 (if available)

Paralogs for RNASE9 Gene

No data available for Paralogs for RNASE9 Gene

Variants for RNASE9 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for RNASE9 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000050087 -- 20,559,295(-) A/G intron_variant
rs1000513244 -- 20,559,190(-) G/A intron_variant
rs1001045529 -- 20,560,719(-) C/G intron_variant
rs1001139962 -- 20,561,212(-) G/T upstream_transcript_variant
rs1001400827 -- 20,558,321(-) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNASE9 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545

Variation tolerance for RNASE9 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASE9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASE9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE9 Gene

Disorders for RNASE9 Gene

Additional Disease Information for RNASE9

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RNASE9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE9 Gene

Publications for RNASE9 Gene

  1. Cloning, expression and location of RNase9 in human epididymis. (PMID: 18992174) Liu J … Wang W (BMC research notes 2008) 3 4 22 58
  2. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S … Zhang J (Genomics 2005) 2 3 4 58
  3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S … Sun J (Carcinogenesis 2012) 3 44 58
  4. Human ribonuclease 9, a member of ribonuclease A superfamily, specifically expressed in epididymis, is a novel sperm-binding protein. (PMID: 19137000) Cheng GZ … Shi GX (Asian journal of andrology 2009) 4 22 58
  5. Discovery in silico and characterization in vitro of novel genes exclusively expressed in the mouse epididymis. (PMID: 12920233) Penttinen J … Poutanen M (Molecular endocrinology (Baltimore, Md.) 2003) 2 3 58

Products for RNASE9 Gene

Sources for RNASE9 Gene

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