The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein is expressed prominently in the placenta and exhibits antimicrobial activity against pathogenic bacteria and fungi. [provided by RefSeq, Oct 2014] See more...

Aliases for RNASE8 Gene

Aliases for RNASE8 Gene

  • Ribonuclease A Family Member 8 2 3 5
  • Ribonuclease, RNase A Family, 8 2 3
  • Ribonuclease 8 3 4
  • RAE2 2 3
  • RNase 8, Placental 3
  • EC 3.1.27.5 51
  • EC 3.1.27.- 4
  • EC 3.1.27 51
  • RNase 8 4
  • RNASE8 5

External Ids for RNASE8 Gene

Previous GeneCards Identifiers for RNASE8 Gene

  • GC14P018898
  • GC14P015313
  • GC14P019516
  • GC14P020595
  • GC14P021525
  • GC14P001647
  • GC14P021059
  • GC14P021117
  • GC14P021124
  • GC14P021130
  • GC14P021211
  • GC14P021060
  • GC14P021067
  • GC14P021075
  • GC14P021077
  • GC14P021087
  • GC14P021096
  • GC14P021110

Summaries for RNASE8 Gene

Entrez Gene Summary for RNASE8 Gene

  • The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein is expressed prominently in the placenta and exhibits antimicrobial activity against pathogenic bacteria and fungi. [provided by RefSeq, Oct 2014]

GeneCards Summary for RNASE8 Gene

RNASE8 (Ribonuclease A Family Member 8) is a Protein Coding gene. Diseases associated with RNASE8 include Esotropia. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease A activity. An important paralog of this gene is RNASE7.

UniProtKB/Swiss-Prot Summary for RNASE8 Gene

Additional gene information for RNASE8 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNASE8 Gene

Genomics for RNASE8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RNASE8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J021055 Enhancer 1.2 Ensembl ENCODE dbSUPER 600.7 -2.0 -1979 1 GATAD2A REST TFE3 NFKBIZ RCOR2 RBFOX2 RXRB IRF2 BRD4 SP1 RNASE8 LOC105370398 RNASE7 NDRG2
GH14J021057 Enhancer 0.7 Ensembl 600.7 +0.4 378 0.4 GATAD2A ATF7 PRDM10 ZIC2 RXRB CTCF RNF2 CREB1 ZNF205 ATF2 RNASE8 ARHGEF40 NDRG2
GH14J021056 Enhancer 0.6 Ensembl dbSUPER 600.7 -1.0 -957 0.7 ZNF511 HMG20B ZNF644 RNASE8 LOC105370398 NDRG2 RNASE7
GH14J020866 Enhancer 0.5 Ensembl 9.8 -190.6 -190624 0.4 CTCF REST RAD21 ZNF654 SIN3A TRIM22 METTL17 EDDM3A RNASE1 TPPP2 ENSG00000255472 RNASE13 RNASE8 MN309174-159 piR-57460-161 ENSG00000259130
GH14J020591 Enhancer 0.4 FANTOM5 11.8 -466.0 -465951 0.1 CBX2 IKZF1 RNASE12 OR4K17 OR6S1 OR11H6 OR4N5 OR11H4 RNASE8 EDDM3B RNASE9 RNASE13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNASE8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNASE8

Top Transcription factor binding sites by QIAGEN in the RNASE8 gene promoter:
  • AML1a
  • Brachyury
  • c-Myc
  • c-Rel
  • FOXJ2
  • FOXJ2 (long isoform)
  • MRF-2
  • MyoD
  • PPAR-alpha
  • TBP

Genomic Locations for RNASE8 Gene

Genomic Locations for RNASE8 Gene
chr14:21,057,822-21,058,455
(GRCh38/hg38)
Size:
634 bases
Orientation:
Plus strand
chr14:21,525,981-21,526,614
(GRCh37/hg19)
Size:
634 bases
Orientation:
Plus strand

Genomic View for RNASE8 Gene

Genes around RNASE8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE8 Gene

Proteins for RNASE8 Gene

  • Protein details for RNASE8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDE3-RNAS8_HUMAN
    Recommended name:
    Ribonuclease 8
    Protein Accession:
    Q8TDE3
    Secondary Accessions:
    • B2RPP6
    • B2RPP7

    Protein attributes for RNASE8 Gene

    Size:
    154 amino acids
    Molecular mass:
    17041 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASE8 Gene

Selected DME Specific Peptides for RNASE8 Gene

Q8TDE3:
  • LLLLLLGLWVA
  • CKDLNTFLH
  • TCQTPNI
  • LVPVHLD
  • LTSGKYPNCRYKE

Post-translational modifications for RNASE8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNASE8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RNASE8 Gene

Gene Families for RNASE8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RNASE8 Gene

InterPro:
Blocks:
  • Pancreatic ribonuclease
ProtoNet:

Suggested Antigen Peptide Sequences for RNASE8 Gene

GenScript: Design optimal peptide antigens:
  • Ribonuclease 8 (RNAS8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TDE3

UniProtKB/Swiss-Prot:

RNAS8_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE8: view

Function for RNASE8 Gene

Molecular function for RNASE8 Gene

UniProtKB/Swiss-Prot Function:
Has a low ribonuclease activity.

Enzyme Numbers (IUBMB) for RNASE8 Gene

Gene Ontology (GO) - Molecular Function for RNASE8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004522 ribonuclease A activity IDA 11861908
GO:0004540 ribonuclease activity IBA 21873635
genes like me logo Genes that share ontologies with RNASE8: view
genes like me logo Genes that share phenotypes with RNASE8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE8

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE8 Gene

Localization for RNASE8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE8 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE8 gene
Compartment Confidence
extracellular 4
nucleus 1

Gene Ontology (GO) - Cellular Components for RNASE8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE8 Gene

Pathways & Interactions for RNASE8 Gene

PathCards logo

SuperPathways for RNASE8 Gene

genes like me logo Genes that share pathways with RNASE8: view

Pathways by source for RNASE8 Gene

3 Reactome pathways for RNASE8 Gene

Interacting Proteins for RNASE8 Gene

Gene Ontology (GO) - Biological Process for RNASE8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response IMP 16940129
GO:0050829 defense response to Gram-negative bacterium IMP 16940129
GO:0050830 defense response to Gram-positive bacterium IDA 16940129
GO:0061760 antifungal innate immune response IDA 16940129
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with RNASE8: view

No data available for SIGNOR curated interactions for RNASE8 Gene

Drugs & Compounds for RNASE8 Gene

No Compound Related Data Available

Transcripts for RNASE8 Gene

mRNA/cDNA for RNASE8 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE8

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE8 Gene

No ASD Table

Relevant External Links for RNASE8 Gene

GeneLoc Exon Structure for
RNASE8

Expression for RNASE8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNASE8 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNASE8

SOURCE GeneReport for Unigene cluster for RNASE8 Gene:

Hs.553572

mRNA Expression by UniProt/SwissProt for RNASE8 Gene:

Q8TDE3-RNAS8_HUMAN
Tissue specificity: Expressed prominently in the placenta and is not detected in any other tissues examined.
genes like me logo Genes that share expression patterns with RNASE8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE8 Gene

Orthologs for RNASE8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RNASE8 30 31
  • 97.84 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 69 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 58 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 31 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves ANG 31
  • 27 (a)
ManyToMany
CL2 31
  • 26 (a)
ManyToMany
RSFR 31
  • 25 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 24 (a)
ManyToMany
-- 31
  • 21 (a)
ManyToMany
Species where no ortholog for RNASE8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RNASE8 Gene

ENSEMBL:
Gene Tree for RNASE8 (if available)
TreeFam:
Gene Tree for RNASE8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNASE8: view image

Paralogs for RNASE8 Gene

(6) SIMAP similar genes for RNASE8 Gene using alignment to 7 proteins:

  • RNAS8_HUMAN
  • H2FJU5_HUMAN
  • H2FJY4_HUMAN
  • H2FJY5_HUMAN
  • H2FJY6_HUMAN
  • H2FJY7_HUMAN
  • H2FJY8_HUMAN
genes like me logo Genes that share paralogs with RNASE8: view

Variants for RNASE8 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNASE8 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs12437266 - p.Pro10Ser

Additional dbSNP identifiers (rs#s) for RNASE8 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNASE8 Gene

Variant ID Type Subtype PubMed ID
nsv1039369 CNV loss 25217958
nsv428293 CNV gain+loss 18775914
nsv826882 CNV gain 20364138
nsv832740 CNV gain 17160897

Variation tolerance for RNASE8 Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASE8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASE8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE8 Gene

Disorders for RNASE8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNASE8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
esotropia
  • convergence in manifest squint
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with RNASE8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE8 Gene

Publications for RNASE8 Gene

  1. RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta. (PMID: 11861908) Zhang J … Rosenberg HF (Nucleic acids research 2002) 2 3 4 23
  2. Disulfide-bond reshuffling in the evolution of an ape placental ribonuclease. (PMID: 17116644) Zhang J (Molecular biology and evolution 2007) 3 23
  3. Identification of RNase 8 as a novel human antimicrobial protein. (PMID: 16940129) Rudolph B … Harder J (Antimicrobial agents and chemotherapy 2006) 3 23
  4. Genetic diversity of human RNase 8. (PMID: 22272736) Chan CC … Rosenberg HF (BMC genomics 2012) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for RNASE8 Gene

  • Signalway ELISA kits for RNASE8

Sources for RNASE8 Gene