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Aliases for RNASE8 Gene

Aliases for RNASE8 Gene

  • Ribonuclease A Family Member 8 2 3 5
  • Ribonuclease, RNase A Family, 8 2 3
  • RNase 8, Placental 3
  • Ribonuclease 8 3
  • EC 56
  • EC 3.1.27.- 4
  • EC 3.1.27 56
  • RNase 8 4
  • RAE2 3

External Ids for RNASE8 Gene

Previous GeneCards Identifiers for RNASE8 Gene

  • GC14P018898
  • GC14P015313
  • GC14P019516
  • GC14P020595
  • GC14P021525
  • GC14P001647
  • GC14P021059
  • GC14P021060
  • GC14P021067
  • GC14P021075
  • GC14P021077

Summaries for RNASE8 Gene

Entrez Gene Summary for RNASE8 Gene

  • The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein is expressed prominently in the placenta and exhibits antimicrobial activity against pathogenic bacteria and fungi. [provided by RefSeq, Oct 2014]

GeneCards Summary for RNASE8 Gene

RNASE8 (Ribonuclease A Family Member 8) is a Protein Coding gene. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease A activity. An important paralog of this gene is RNASE7.

UniProtKB/Swiss-Prot for RNASE8 Gene

  • Has a low ribonuclease activity.

Additional gene information for RNASE8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE8 Gene

Genomics for RNASE8 Gene

GeneHancer (GH) Regulatory Elements for RNASE8 Gene

Promoters and enhancers for RNASE8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I021055 Enhancer 1.1 ENCODE dbSUPER 550.8 -2.0 -1979 1 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 RXRA SP5 NFYC RNASE8 LOC105370398 NDRG2
GH14I021057 Promoter 0.9 EPDnew 550.8 +0.1 50 0.1 GATAD2A RNF2 ARID4B ZIC2 RAD21 ATF2 NFIL3 ZFHX2 CREB1 ATF7 RNASE8 ARHGEF40 NDRG2
GH14I020591 Enhancer 0.3 FANTOM5 11.8 -466.0 -465951 0.1 IKZF1 RNASE12 OR4K17 OR6S1 OR11H6 OR4N5 OR11H4 RNASE8 EDDM3B RNASE9 RNASE13
GH14I021054 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 0.8 -3.3 -3280 0.3 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 SLC30A9 RXRA LOC105370398 RNASE8 NDRG2
GH14I021060 Enhancer 0.9 ENCODE dbSUPER 0.8 +3.1 3143 1.2 CEBPG YY1 ZFHX2 POLR2A NR2F6 THAP11 EGR2 HLF CEBPB ELF1 ARHGEF40 RNASE8 NDRG2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNASE8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNASE8 gene promoter:

Genomic Locations for RNASE8 Gene

Genomic Locations for RNASE8 Gene
634 bases
Plus strand

Genomic View for RNASE8 Gene

Genes around RNASE8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE8 Gene

Proteins for RNASE8 Gene

  • Protein details for RNASE8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease 8
    Protein Accession:
    Secondary Accessions:
    • B2RPP6
    • B2RPP7

    Protein attributes for RNASE8 Gene

    154 amino acids
    Molecular mass:
    17041 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASE8 Gene

Selected DME Specific Peptides for RNASE8 Gene


Post-translational modifications for RNASE8 Gene

No Post-translational modifications

Other Protein References for RNASE8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RNASE8 Gene

Gene Families for RNASE8 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RNASE8 Gene

Suggested Antigen Peptide Sequences for RNASE8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pancreatic ribonuclease family.
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE8: view

Function for RNASE8 Gene

Molecular function for RNASE8 Gene

UniProtKB/Swiss-Prot Function:
Has a low ribonuclease activity.

Enzyme Numbers (IUBMB) for RNASE8 Gene

Phenotypes From GWAS Catalog for RNASE8 Gene

Gene Ontology (GO) - Molecular Function for RNASE8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004522 ribonuclease A activity IDA 11861908
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RNASE8: view
genes like me logo Genes that share phenotypes with RNASE8: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE8 Gene

Localization for RNASE8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE8 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE8 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for RNASE8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE8 Gene

Pathways & Interactions for RNASE8 Gene

genes like me logo Genes that share pathways with RNASE8: view

Pathways by source for RNASE8 Gene

3 Reactome pathways for RNASE8 Gene

Interacting Proteins for RNASE8 Gene

Gene Ontology (GO) - Biological Process for RNASE8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045087 innate immune response IMP 16940129
GO:0050829 defense response to Gram-negative bacterium IMP 16940129
GO:0050830 defense response to Gram-positive bacterium IDA 16940129
GO:0061760 antifungal innate immune response IDA 16940129
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with RNASE8: view

No data available for SIGNOR curated interactions for RNASE8 Gene

Drugs & Compounds for RNASE8 Gene

No Compound Related Data Available

Transcripts for RNASE8 Gene

mRNA/cDNA for RNASE8 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE8 Gene

No ASD Table

Relevant External Links for RNASE8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNASE8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNASE8 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNASE8 Gene:


SOURCE GeneReport for Unigene cluster for RNASE8 Gene:


mRNA Expression by UniProt/SwissProt for RNASE8 Gene:

Tissue specificity: Expressed prominently in the placenta and is not detected in any other tissues examined.
genes like me logo Genes that share expression patterns with RNASE8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE8 Gene

Orthologs for RNASE8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNASE8 33 34
  • 97.84 (n)
(Bos Taurus)
Mammalia -- 34
  • 69 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 31 (a)
(Gallus gallus)
Aves ANG 34
  • 27 (a)
CL2 34
  • 26 (a)
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 24 (a)
-- 34
  • 21 (a)
Species where no ortholog for RNASE8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE8 Gene

Gene Tree for RNASE8 (if available)
Gene Tree for RNASE8 (if available)

Paralogs for RNASE8 Gene

Paralogs for RNASE8 Gene

(6) SIMAP similar genes for RNASE8 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RNASE8: view

Variants for RNASE8 Gene

Sequence variations from dbSNP and Humsavar for RNASE8 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1003105398 -- 21,058,713(+) G/A downstream_transcript_variant
rs1006014096 -- 21,056,982(+) A/G upstream_transcript_variant
rs1006059215 -- 21,056,270(+) A/G upstream_transcript_variant
rs1007099327 -- 21,057,479(+) G/T upstream_transcript_variant
rs1007519818 -- 21,057,256(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNASE8 Gene

Variant ID Type Subtype PubMed ID
nsv832740 CNV gain 17160897
nsv826882 CNV gain 20364138
nsv428293 CNV gain+loss 18775914
nsv1039369 CNV loss 25217958

Variation tolerance for RNASE8 Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASE8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE8 Gene

Disorders for RNASE8 Gene

Additional Disease Information for RNASE8

No disorders were found for RNASE8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNASE8 Gene

Publications for RNASE8 Gene

  1. RNase 8, a novel RNase A superfamily ribonuclease expressed uniquely in placenta. (PMID: 11861908) Zhang J … Rosenberg HF (Nucleic acids research 2002) 2 3 4 22 58
  2. Disulfide-bond reshuffling in the evolution of an ape placental ribonuclease. (PMID: 17116644) Zhang J (Molecular biology and evolution 2007) 3 22 58
  3. Identification of RNase 8 as a novel human antimicrobial protein. (PMID: 16940129) Rudolph B … Harder J (Antimicrobial agents and chemotherapy 2006) 3 22 58
  4. Genetic diversity of human RNase 8. (PMID: 22272736) Chan CC … Rosenberg HF (BMC genomics 2012) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for RNASE8 Gene

Sources for RNASE8 Gene

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