The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014] See more...

Aliases for RNASE7 Gene

Aliases for RNASE7 Gene

  • Ribonuclease A Family Member 7 2 3 5
  • Skin-Derived Antimicrobial Protein 2 3 4
  • Ribonuclease, RNase A Family, 7 2 3
  • Ribonuclease 7 3 4
  • RNase 7 3 4
  • SAP-2 3 4
  • RAE1 2 3
  • EC 3.1.27.5 51
  • EC 3.1.27.- 4
  • EC 3.1.27 51
  • RNASE7 5

External Ids for RNASE7 Gene

Previous GeneCards Identifiers for RNASE7 Gene

  • GC14P018883
  • GC14P015298
  • GC14P019500
  • GC14P020580
  • GC14P021510
  • GC14P001631

Summaries for RNASE7 Gene

Entrez Gene Summary for RNASE7 Gene

  • The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

GeneCards Summary for RNASE7 Gene

RNASE7 (Ribonuclease A Family Member 7) is a Protein Coding gene. Diseases associated with RNASE7 include Pityriasis Versicolor and Psoriasis. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE8.

UniProtKB/Swiss-Prot Summary for RNASE7 Gene

  • Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:25075772, PubMed:17150966). Causes loss of bacterial membrane integrity (PubMed:17150966). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:17150966).

Additional gene information for RNASE7 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNASE7 Gene

Genomics for RNASE7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RNASE7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNASE7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNASE7

Top Transcription factor binding sites by QIAGEN in the RNASE7 gene promoter:
  • c-Rel
  • CREB
  • deltaCREB
  • Nkx2-5
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • RP58
  • Spz1
  • TBP

Genomic Locations for RNASE7 Gene

Genomic Locations for RNASE7 Gene
chr14:21,042,316-21,044,234
(GRCh38/hg38)
Size:
1,919 bases
Orientation:
Plus strand
chr14:21,510,385-21,512,393
(GRCh37/hg19)
Size:
2,009 bases
Orientation:
Plus strand

Genomic View for RNASE7 Gene

Genes around RNASE7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE7 Gene

Proteins for RNASE7 Gene

  • Protein details for RNASE7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1E1-RNAS7_HUMAN
    Recommended name:
    Ribonuclease 7
    Protein Accession:
    Q9H1E1
    Secondary Accessions:
    • P80927
    • P83685
    • Q546N3

    Protein attributes for RNASE7 Gene

    Size:
    156 amino acids
    Molecular mass:
    17419 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNASE7 Gene

neXtProt entry for RNASE7 Gene

Selected DME Specific Peptides for RNASE7 Gene

Q9H1E1:
  • LLLLLLGLWVA
  • CKDLNTFLH
  • LVPVHLD
  • LTSGKYPNCRYKE

Post-translational modifications for RNASE7 Gene

  • Glycosylation at Asn127
  • Modification sites at PhosphoSitePlus

Other Protein References for RNASE7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RNASE7 Gene

Gene Families for RNASE7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RNASE7 Gene

InterPro:
Blocks:
  • Pancreatic ribonuclease
ProtoNet:

Suggested Antigen Peptide Sequences for RNASE7 Gene

GenScript: Design optimal peptide antigens:
  • Ribonuclease, RNase A family, 7, isoform CRA_a (D3DS13_HUMAN)
  • Skin-derived antimicrobial protein 2 (RNAS7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H1E1

UniProtKB/Swiss-Prot:

RNAS7_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE7: view

Function for RNASE7 Gene

Molecular function for RNASE7 Gene

UniProtKB/Swiss-Prot Function:
Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:25075772, PubMed:17150966). Causes loss of bacterial membrane integrity (PubMed:17150966). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:17150966).
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to the cytokines IL1B, IFNG and TNF (PubMed:12244054). Strongly up-regulated in response to the bacterium P.aeruginosa (PubMed:12244054). Moderately up-regulated in response to S.aureus, E.coli and S.pyogenes (PubMed:12244054). Up-regulated in kidney in response to infection (PubMed:25075772).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.2 uM for tRNA {ECO:0000269|PubMed:12244054};

Enzyme Numbers (IUBMB) for RNASE7 Gene

Phenotypes From GWAS Catalog for RNASE7 Gene

Gene Ontology (GO) - Molecular Function for RNASE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 20180804
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004540 ribonuclease activity IBA,IDA 12244054
genes like me logo Genes that share ontologies with RNASE7: view
genes like me logo Genes that share phenotypes with RNASE7: view

Animal Model Products

CRISPR Products

miRNA for RNASE7 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE7

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE7 Gene

Localization for RNASE7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE7 Gene

Secreted. Note=Detected in urine. {ECO:0000269 PubMed:25075772}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE7 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RNASE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 25075772
GO:0005737 cytoplasm IDA 25075772
genes like me logo Genes that share ontologies with RNASE7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE7 Gene

Pathways & Interactions for RNASE7 Gene

PathCards logo

SuperPathways for RNASE7 Gene

genes like me logo Genes that share pathways with RNASE7: view

Pathways by source for RNASE7 Gene

3 Reactome pathways for RNASE7 Gene

Interacting Proteins for RNASE7 Gene

Gene Ontology (GO) - Biological Process for RNASE7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019730 antimicrobial humoral response TAS --
GO:0019731 antibacterial humoral response IDA 23302724
GO:0042742 defense response to bacterium IEA --
GO:0045087 innate immune response NAS 12244054
GO:0050829 defense response to Gram-negative bacterium IDA 12244054
genes like me logo Genes that share ontologies with RNASE7: view

No data available for SIGNOR curated interactions for RNASE7 Gene

Drugs & Compounds for RNASE7 Gene

(1) Drugs for RNASE7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RNASE7: view

Transcripts for RNASE7 Gene

mRNA/cDNA for RNASE7 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE7

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for RNASE7 Gene

GeneLoc Exon Structure for
RNASE7

Expression for RNASE7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNASE7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE7 Gene

This gene is overexpressed in Esophagus - Mucosa (x22.0), Skin - Sun Exposed (Lower leg) (x10.7), Vagina (x6.4), and Skin - Not Sun Exposed (Suprapubic) (x5.1).

Protein differential expression in normal tissues from HIPED for RNASE7 Gene

This gene is overexpressed in Cervix (60.3) and Urinary Bladder (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE7 Gene



Protein tissue co-expression partners for RNASE7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNASE7

SOURCE GeneReport for Unigene cluster for RNASE7 Gene:

Hs.525206

mRNA Expression by UniProt/SwissProt for RNASE7 Gene:

Q9H1E1-RNAS7_HUMAN
Tissue specificity: Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level) (PubMed:25075772). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut (PubMed:12244054). Expressed in liver, kidney, skeletal muscle and heart (PubMed:12527768).

Evidence on tissue expression from TISSUES for RNASE7 Gene

  • Skin(4.6)
  • Kidney(4.4)
genes like me logo Genes that share expression patterns with RNASE7: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE7 Gene

Orthologs for RNASE7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RNASE7 30 31
  • 98.72 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RNASE7 30
  • 79.27 (n)
-- 31
  • 72 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 54 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 34 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves RSFR 31
  • 29 (a)
ManyToMany
ANG 31
  • 28 (a)
ManyToMany
CL2 31
  • 26 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 26 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
Species where no ortholog for RNASE7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RNASE7 Gene

ENSEMBL:
Gene Tree for RNASE7 (if available)
TreeFam:
Gene Tree for RNASE7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNASE7: view image

Paralogs for RNASE7 Gene

(6) SIMAP similar genes for RNASE7 Gene using alignment to 2 proteins:

  • RNAS7_HUMAN
  • D3DS13_HUMAN
genes like me logo Genes that share paralogs with RNASE7: view

Variants for RNASE7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNASE7 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs1243469 - p.His116Tyr
rs1263872 - p.Ala103Pro

Additional dbSNP identifiers (rs#s) for RNASE7 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNASE7 Gene

Variant ID Type Subtype PubMed ID
nsv1039369 CNV loss 25217958
nsv428293 CNV gain+loss 18775914
nsv826882 CNV gain 20364138
nsv832740 CNV gain 17160897

Variation tolerance for RNASE7 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASE7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASE7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE7 Gene

Disorders for RNASE7 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RNASE7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pityriasis versicolor
  • infection by pityrosporum furfur
psoriasis
superficial mycosis
  • piedra
pyelitis
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with RNASE7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE7 Gene

Publications for RNASE7 Gene

  1. Human RNase 7: a new cationic ribonuclease of the RNase A superfamily. (PMID: 12527768) Zhang J … Rosenberg HF (Nucleic acids research 2003) 2 3 4 23
  2. RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin. (PMID: 12244054) Harder J … Schroder JM (The Journal of biological chemistry 2002) 2 3 4 23
  3. Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract. (PMID: 25075772) Becknell B … Spencer JD (Kidney international 2015) 3 4
  4. Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram-negative and Gram-positive bacterial cell wall. (PMID: 20180804) Torrent M … Boix E (The FEBS journal 2010) 3 23
  5. Constitutive expression of the antimicrobial peptide RNase 7 is associated with Staphylococcus aureus infection of the skin. (PMID: 19919305) Zanger P … Gabrysch S (The Journal of infectious diseases 2009) 3 23

Products for RNASE7 Gene

Sources for RNASE7 Gene