Aliases for RNASE7 Gene
External Ids for RNASE7 Gene
Previous GeneCards Identifiers for RNASE7 Gene
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
GeneCards Summary for RNASE7 Gene
RNASE7 (Ribonuclease A Family Member 7) is a Protein Coding gene. Diseases associated with RNASE7 include Superficial Mycosis and Pityriasis Versicolor. Among its related pathways are Defensins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE8.
UniProtKB/Swiss-Prot Summary for RNASE7 Gene
Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:25075772, PubMed:17150966). Causes loss of bacterial membrane integrity (PubMed:17150966). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:17150966).