Aliases for RNASE6 Gene
External Ids for RNASE6 Gene
Previous HGNC Symbols for RNASE6 Gene
Previous GeneCards Identifiers for RNASE6 Gene
The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014]
GeneCards Summary for RNASE6 Gene
RNASE6 (Ribonuclease A Family Member K6) is a Protein Coding gene. Diseases associated with RNASE6 include Nodular Nonsuppurative Panniculitis. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE7.
UniProtKB/Swiss-Prot Summary for RNASE6 Gene
Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:8836175, PubMed:27013146). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:25075772, PubMed:27089320). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed:27089320). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:27089320).