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Aliases for RNASE4 Gene

Aliases for RNASE4 Gene

  • Ribonuclease A Family Member 4 2 3 5
  • Ribonuclease, RNase A Family, 4 2 3
  • RNase 4 3 4
  • RNS4 3 4
  • Ribonuclease A B1 3
  • Ribonuclease 4 3
  • EC 3.1.27.- 4
  • RAB1 3

External Ids for RNASE4 Gene

Previous GeneCards Identifiers for RNASE4 Gene

  • GC14P018523
  • GC14P014939
  • GC14P019142
  • GC14P020222
  • GC14P021153
  • GC14P001274
  • GC14P021155
  • GC14P021157
  • GC14P021166
  • GC14P021170
  • GC14P021176
  • GC14P021185
  • GC14P021191
  • GC14P020688
  • GC14P020696
  • GC14P020704
  • GC14P020714
  • GC14P020724
  • GC14P020736
  • GC14P020746
  • GC14P020755

Summaries for RNASE4 Gene

Entrez Gene Summary for RNASE4 Gene

  • The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]

GeneCards Summary for RNASE4 Gene

RNASE4 (Ribonuclease A Family Member 4) is a Protein Coding gene. Diseases associated with RNASE4 include Amyotrophic Lateral Sclerosis 1. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE1.

UniProtKB/Swiss-Prot for RNASE4 Gene

  • This RNase has marked specificity towards the 3 side of uridine nucleotides.

Gene Wiki entry for RNASE4 Gene

Additional gene information for RNASE4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE4 Gene

Genomics for RNASE4 Gene

GeneHancer (GH) Regulatory Elements for RNASE4 Gene

Promoters and enhancers for RNASE4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020679 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 670 +0.4 433 9.8 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RNASE4 ANG TRP-TGG3-2 TRY-GTA5-5 PIR55020 ENSG00000259171 METTL3 SUPT16H CHD8 METTL17
GH14J020691 Enhancer 1.1 Ensembl ENCODE 9.7 +7.2 7200 0.6 ARID4B SIN3A ZNF2 IRF4 YY1 ZNF213 ARID2 ZNF143 ATF7 PAF1 SUPT16H METTL3 METTL17 RNASE4 ANG ENSG00000259171 ENSG00000258451
GH14J020662 Enhancer 1.2 Ensembl ENCODE 6.6 -20.4 -20399 1.8 ARID4B SIN3A ZNF2 IRF4 YY1 ZNF213 ZNF207 ZNF143 KLF13 SP3 TRY-GTA5-4 PARP2 SUPT16H ENSG00000258515 METTL3 CHD8 TTC5 METTL17 PIP4P1 ENSG00000258768
GH14J020697 Enhancer 1 Ensembl ENCODE 7.6 +13.8 13767 0.5 MEIS2 CTCF RAD21 RFX5 YY1 TCF12 CC2D1A GATA3 GATA2 NCOR1 SUPT16H RNASE4 ENSG00000258451 ANG ENSG00000259171
GH14J020692 Enhancer 0.4 dbSUPER 8.1 +8.3 8346 0.4 ZNF639 NRF1 RNASE4 ENSG00000259171 ANG ENSG00000258451
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNASE4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNASE4 gene promoter:
  • Nkx2-5
  • COUP
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • AP-1
  • RSRFC4
  • STAT3
  • deltaCREB

Genomic Locations for RNASE4 Gene

Genomic Locations for RNASE4 Gene
17,116 bases
Plus strand
16,503 bases
Plus strand

Genomic View for RNASE4 Gene

Genes around RNASE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE4 Gene

Proteins for RNASE4 Gene

  • Protein details for RNASE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease 4
    Protein Accession:

    Protein attributes for RNASE4 Gene

    147 amino acids
    Molecular mass:
    16840 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RNASE4 Gene

neXtProt entry for RNASE4 Gene

Post-translational modifications for RNASE4 Gene

No Post-translational modifications

Other Protein References for RNASE4 Gene

No data available for DME Specific Peptides for RNASE4 Gene

Domains & Families for RNASE4 Gene

Gene Families for RNASE4 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for RNASE4 Gene

Suggested Antigen Peptide Sequences for RNASE4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pancreatic ribonuclease family.
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE4: view

Function for RNASE4 Gene

Molecular function for RNASE4 Gene

UniProtKB/Swiss-Prot Function:
This RNase has marked specificity towards the 3 side of uridine nucleotides.
GENATLAS Biochemistry:
ribonuclease,RNAse A family,4,expressed in a number of human somatic tissues but not brain,with two alternatively spliced isoforms

Enzyme Numbers (IUBMB) for RNASE4 Gene

Phenotypes From GWAS Catalog for RNASE4 Gene

Gene Ontology (GO) - Molecular Function for RNASE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IBA --
GO:0004522 ribonuclease A activity NAS 7742370
GO:0004540 ribonuclease activity IBA --
genes like me logo Genes that share ontologies with RNASE4: view
genes like me logo Genes that share phenotypes with RNASE4: view

Animal Model Products

miRNA for RNASE4 Gene

miRTarBase miRNAs that target RNASE4

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE4 Gene

Localization for RNASE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE4 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for RNASE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IDA 3467790
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with RNASE4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE4 Gene

Pathways & Interactions for RNASE4 Gene

SuperPathways for RNASE4 Gene

No Data Available

Interacting Proteins for RNASE4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: P34096-RNAS4_HUMAN ENSP00000381081 for RNASE4 Gene via IID STRING

Gene Ontology (GO) - Biological Process for RNASE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006379 mRNA cleavage NAS 7742370
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RNASE4: view

No data available for Pathways by source and SIGNOR curated interactions for RNASE4 Gene

Drugs & Compounds for RNASE4 Gene

(2) Drugs for RNASE4 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2'-Deoxyuridine 3'-Monophosphate Experimental Pharma Target 0
genes like me logo Genes that share compounds with RNASE4: view

Transcripts for RNASE4 Gene

mRNA/cDNA for RNASE4 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE4 Gene

No ASD Table

Relevant External Links for RNASE4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNASE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNASE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNASE4 Gene

This gene is overexpressed in Serum (17.7), Plasma (14.6), Saliva (10.2), and Milk (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE4 Gene

Protein tissue co-expression partners for RNASE4 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNASE4 Gene:


Evidence on tissue expression from TISSUES for RNASE4 Gene

  • Bone marrow(4)
  • Pancreas(4)
  • Liver(3.3)
genes like me logo Genes that share expression patterns with RNASE4: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE4 Gene

Orthologs for RNASE4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNASE4 34 33
  • 99.77 (n)
(Bos Taurus)
Mammalia RNASE4 34 33
  • 89.5 (n)
(Mus musculus)
Mammalia Rnase4 16 34 33
  • 84.47 (n)
(Canis familiaris)
Mammalia RNASE4 34 33
  • 83.87 (n)
(Rattus norvegicus)
Mammalia Rnase4 33
  • 81.05 (n)
(Ornithorhynchus anatinus)
Mammalia RNASE4 34
  • 69 (a)
(Monodelphis domestica)
Mammalia RNASE4 34
  • 66 (a)
(Gallus gallus)
Aves RSFR 34
  • 35 (a)
ANG 34
  • 33 (a)
CL2 34
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 41 (a)
-- 34
  • 34 (a)
Species where no ortholog for RNASE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE4 Gene

Gene Tree for RNASE4 (if available)
Gene Tree for RNASE4 (if available)
Evolutionary constrained regions (ECRs) for RNASE4: view image

Paralogs for RNASE4 Gene

Paralogs for RNASE4 Gene

(3) SIMAP similar genes for RNASE4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RNASE4: view

Variants for RNASE4 Gene

Sequence variations from dbSNP and Humsavar for RNASE4 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1054016022 uncertain-significance, Amyotrophic Lateral Sclerosis, Dominant 20,684,253(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant
rs113950902 likely-benign, Amyotrophic Lateral Sclerosis, Dominant 20,684,394(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant
rs11701 benign, likely-benign, not specified, Amyotrophic Lateral Sclerosis, Dominant 20,693,894(+) T/A/G intron_variant
rs117053048 likely-benign, Amyotrophic Lateral Sclerosis, Dominant 20,684,247(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant
rs117466368 likely-benign, Amyotrophic Lateral Sclerosis, Dominant 20,684,198(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNASE4 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545
esv3633687 CNV loss 21293372
esv3633688 CNV loss 21293372
nsv1203 CNV deletion 18451855

Variation tolerance for RNASE4 Gene

Residual Variation Intolerance Score: 73.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE4 Gene

Disorders for RNASE4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNASE4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RNASE4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RNASE4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE4 Gene

Publications for RNASE4 Gene

  1. Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues. (PMID: 7501448) Rosenberg HF … Dyer KD (Nucleic acids research 1995) 2 3 4 22 58
  2. The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. (PMID: 9878400) Terzyan SS … Coll M (Journal of molecular biology 1999) 3 4 22 58
  3. The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine. (PMID: 8223579) Zhou HM … Strydom DJ (European journal of biochemistry 1993) 3 4 22 58
  4. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J … ENGAGE Consortium (PLoS genetics 2010) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RNASE4 Gene

Sources for RNASE4 Gene

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