The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014] See more...

Aliases for RNASE3 Gene

Aliases for RNASE3 Gene

  • Ribonuclease A Family Member 3 2 3 5
  • Eosinophil Cationic Protein 2 3 4
  • ECP 2 3 4
  • Ribonuclease, RNase A Family, 3 2 3
  • Ribonuclease 3 3 4
  • RNase 3 3 4
  • RAF1 2 3
  • RNS3 3 4
  • Cytotoxic Ribonuclease 3
  • EC 3.1.27.5 51
  • EC 3.1.27.- 4
  • EC 3.1.27 51
  • RNASE3 5

External Ids for RNASE3 Gene

Previous HGNC Symbols for RNASE3 Gene

  • RNS3

Previous GeneCards Identifiers for RNASE3 Gene

  • GC14P018731
  • GC14P015146
  • GC14P019349
  • GC14P020429
  • GC14P021359
  • GC14P001480

Summaries for RNASE3 Gene

Entrez Gene Summary for RNASE3 Gene

  • The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]

GeneCards Summary for RNASE3 Gene

RNASE3 (Ribonuclease A Family Member 3) is a Protein Coding gene. Diseases associated with RNASE3 include Allergic Rhinitis and Rhinitis. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE2.

UniProtKB/Swiss-Prot Summary for RNASE3 Gene

  • Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.

Gene Wiki entry for RNASE3 Gene

Additional gene information for RNASE3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNASE3 Gene

Genomics for RNASE3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RNASE3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020890 Promoter 0.7 EPDnew Ensembl 600.7 -0.1 -98 0.2 RNASE3 ENSG00000258642 LOC100507513 RNASE1
GH14J020944 Enhancer 0.3 Ensembl 5 +53.9 53902 5.4 SPI1 IKZF1 ENSG00000136315 ENSG00000259001 RNASE3 LOC100507513 lnc-RNASE2-1 RNASE2
GH14J020426 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 1.4 -463.3 -463291 2.7 SP1 GATAD2A PRDM10 IKZF1 JUND PRDM1 RXRB IKZF2 POLR2A TRIM22 piR-32214-162 OSGEP PNP PIP4P1 APEX1 RNASE11 TEP1 KLHL33 RNASE6 RNASE3
GH14J020873 Promoter/Enhancer 1.1 Ensembl ENCODE 0.4 -17.5 -17498 1 CTCF GABPA ZNF143 REST RAD21 EZH2 EED ZNF444 BCLAF1 ZBTB40 ENSG00000258642 ENSG00000259130 EDDM3A RNASE3 LOC100507513 RNASE1
GH14J020855 Enhancer 1 Ensembl ENCODE 0.3 -35.6 -35598 0.8 CTCF REST RFX1 RAD21 TRIM22 USF2 ZNF10 RAD51 GATAD2A ZNF444 RNASE1 EDDM3A piR-48222-117 piR-32214-163 ENSG00000259130 RNASE3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNASE3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNASE3

Top Transcription factor binding sites by QIAGEN in the RNASE3 gene promoter:
  • AML1a
  • C/EBPalpha
  • CHOP-10
  • Evi-1
  • Lmo2
  • NF-kappaB
  • NF-kappaB1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for RNASE3 Gene

Genomic Locations for RNASE3 Gene
chr14:20,891,399-20,892,348
(GRCh38/hg38)
Size:
950 bases
Orientation:
Plus strand
chr14:21,359,558-21,360,507
(GRCh37/hg19)
Size:
950 bases
Orientation:
Plus strand

Genomic View for RNASE3 Gene

Genes around RNASE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE3 Gene

Proteins for RNASE3 Gene

  • Protein details for RNASE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12724-ECP_HUMAN
    Recommended name:
    Eosinophil cationic protein
    Protein Accession:
    P12724
    Secondary Accessions:
    • Q4VBC1
    • Q8WTP7
    • Q8WZ62
    • Q9GZN9

    Protein attributes for RNASE3 Gene

    Size:
    160 amino acids
    Molecular mass:
    18385 Da
    Quaternary structure:
    • Interacts with bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA). In vitro interacts with and insert into lipid bilayers composed of dioleoyl phosphatidylcholine and dioleoyl phosphatidylglycerol. In vitro, tends to form amyloid-like aggregates at pH 3, but not at pH 5, nor 7.

    Three dimensional structures from OCA and Proteopedia for RNASE3 Gene

neXtProt entry for RNASE3 Gene

Selected DME Specific Peptides for RNASE3 Gene

P12724:
  • RVPLLHCDLINPGAQNIS
  • VACDNRD
  • RCKNQNTFL
  • QICLLLLLGLMGVEGSLHARPPQFT
  • VVNVCGN
  • YPVVPVHLD

Post-translational modifications for RNASE3 Gene

  • Glycosylation at Asn84, Asn92, and Asn119
  • Modification sites at PhosphoSitePlus

Other Protein References for RNASE3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RNASE3 Gene

Gene Families for RNASE3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RNASE3 Gene

InterPro:
Blocks:
  • Pancreatic ribonuclease
ProtoNet:

Suggested Antigen Peptide Sequences for RNASE3 Gene

GenScript: Design optimal peptide antigens:
  • Ribonuclease 3 (ECP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P12724

UniProtKB/Swiss-Prot:

ECP_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE3: view

Function for RNASE3 Gene

Molecular function for RNASE3 Gene

UniProtKB/Swiss-Prot Function:
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.
GENATLAS Biochemistry:
ribonuclease RNAse A family,3,eosinophil cationic protein

Enzyme Numbers (IUBMB) for RNASE3 Gene

Phenotypes From GWAS Catalog for RNASE3 Gene

Gene Ontology (GO) - Molecular Function for RNASE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IDA 23992292
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004540 ribonuclease activity IBA 21873635
genes like me logo Genes that share ontologies with RNASE3: view
genes like me logo Genes that share phenotypes with RNASE3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE3 Gene

Localization for RNASE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE3 Gene

Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE3 gene
Compartment Confidence
extracellular 5
lysosome 4
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
golgi apparatus 2
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for RNASE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 12860195
GO:0035578 azurophil granule lumen TAS --
genes like me logo Genes that share ontologies with RNASE3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE3 Gene

Pathways & Interactions for RNASE3 Gene

PathCards logo

SuperPathways for RNASE3 Gene

genes like me logo Genes that share pathways with RNASE3: view

Pathways by source for RNASE3 Gene

1 KEGG pathway for RNASE3 Gene

Gene Ontology (GO) - Biological Process for RNASE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0006401 RNA catabolic process TAS 2745977
GO:0019730 antimicrobial humoral response TAS --
GO:0019731 antibacterial humoral response IDA 12860195
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with RNASE3: view

No data available for SIGNOR curated interactions for RNASE3 Gene

Drugs & Compounds for RNASE3 Gene

(55) Drugs for RNASE3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citric acid Approved, Vet_approved Nutra Activator, Agonist, Target 1509
Adenosine-2'-5'-Diphosphate Experimental Pharma Target 0
Pranlukast Investigational Pharma Antagonist, Target, other/unknown 4

(59) Additional Compounds for RNASE3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RNASE3: view

Transcripts for RNASE3 Gene

mRNA/cDNA for RNASE3 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE3

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE3 Gene

No ASD Table

Relevant External Links for RNASE3 Gene

GeneLoc Exon Structure for
RNASE3

Expression for RNASE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNASE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE3 Gene

This gene is overexpressed in Whole Blood (x43.3).

Protein differential expression in normal tissues from HIPED for RNASE3 Gene

This gene is overexpressed in Neutrophil (54.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE3 Gene



Protein tissue co-expression partners for RNASE3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNASE3

SOURCE GeneReport for Unigene cluster for RNASE3 Gene:

Hs.73839

Evidence on tissue expression from TISSUES for RNASE3 Gene

  • Intestine(4.5)
  • Bone marrow(3.5)
  • Blood(3.3)
  • Lung(2.9)
  • Skin(2.5)
  • Liver(2.5)
  • Heart(2.4)
  • Nervous system(2.4)
  • Urine(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with RNASE3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE3 Gene

Orthologs for RNASE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE3 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia -- 31
  • 51 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ear1 31
  • 49 (a)
ManyToMany
Ear11 31
  • 49 (a)
ManyToMany
Ear10 31
  • 48 (a)
ManyToMany
Ear6 31
  • 48 (a)
ManyToMany
Ear2 31
  • 47 (a)
ManyToMany
Ear5 31
  • 46 (a)
ManyToMany
Ear14 31
  • 46 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 34 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 29 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves ANG 31
  • 24 (a)
ManyToMany
RSFR 31
  • 24 (a)
ManyToMany
CL2 31
  • 20 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 24 (a)
ManyToMany
-- 31
  • 23 (a)
ManyToMany
Species where no ortholog for RNASE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RNASE3 Gene

ENSEMBL:
Gene Tree for RNASE3 (if available)
TreeFam:
Gene Tree for RNASE3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNASE3: view image

Paralogs for RNASE3 Gene

(5) SIMAP similar genes for RNASE3 Gene using alignment to 1 proteins:

  • ECP_HUMAN
genes like me logo Genes that share paralogs with RNASE3: view

Variants for RNASE3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNASE3 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs12147890 - p.Gly130Arg
rs151169198 - p.Arg72Cys
rs2073342 - p.Thr124Arg

Additional dbSNP identifiers (rs#s) for RNASE3 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNASE3 Gene

Variant ID Type Subtype PubMed ID
dgv1798n100 CNV gain+loss 25217958
dgv1799n100 CNV loss 25217958
dgv1800n100 CNV gain 25217958
dgv1801n100 CNV gain 25217958
dgv1802n100 CNV loss 25217958
dgv34e203 CNV gain+loss 21179565
dgv363n67 CNV gain 20364138
dgv380e214 CNV gain 21293372
dgv381e214 CNV loss 21293372
esv2421825 OTHER complex 20811451
esv2673725 CNV deletion 23128226
esv2759972 CNV gain+loss 17122850
esv29488 CNV loss 19812545
esv3584663 CNV loss 24956385
esv3892467 CNV gain+loss 25118596
nsv1044554 CNV gain 25217958
nsv1050170 CNV gain+loss 25217958
nsv1204 CNV deletion 18451855
nsv1205 CNV insertion 18451855
nsv428293 CNV gain+loss 18775914
nsv433274 CNV loss 18776910
nsv436831 CNV insertion 17901297
nsv442680 CNV gain+loss 18776908
nsv470622 CNV loss 18288195
nsv498822 CNV loss 21111241
nsv517174 CNV gain+loss 19592680
nsv563847 CNV loss 21841781
nsv817619 CNV gain 17921354
nsv832740 CNV gain 17160897
nsv9121 CNV gain+loss 18304495
nsv983967 CNV duplication 23825009

Variation tolerance for RNASE3 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.44; 9.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASE3 Gene

Human Gene Mutation Database (HGMD)
RNASE3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE3 Gene

Disorders for RNASE3 Gene

MalaCards: The human disease database

(90) MalaCards diseases for RNASE3 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RNASE3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RNASE3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE3 Gene

Publications for RNASE3 Gene

  1. Identification of polymorphisms in the RNase3 gene and the association with allergic rhinitis. (PMID: 19760211) Kang I … Lee JH (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2010) 3 23 41
  2. Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany. (PMID: 19014520) Parwez Q … Hoffjan S (Journal of negative results in biomedicine 2008) 3 23 41
  3. Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes. (PMID: 17362255) Munthe-Kaas MC … Carlsen KL (Allergy 2007) 3 23 41
  4. The crystal structure of eosinophil cationic protein in complex with 2',5'-ADP at 2.0 A resolution reveals the details of the ribonucleolytic active site. (PMID: 12356310) Mohan CG … Acharya KR (Biochemistry 2002) 3 4 23
  5. Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution. (PMID: 10903870) Mallorquí-Fernández G … Coll M (Journal of molecular biology 2000) 3 4 23

Products for RNASE3 Gene

Sources for RNASE3 Gene