Aliases for RNASE3 Gene
External Ids for RNASE3 Gene
Previous HGNC Symbols for RNASE3 Gene
Previous GeneCards Identifiers for RNASE3 Gene
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]
GeneCards Summary for RNASE3 Gene
RNASE3 (Ribonuclease A Family Member 3) is a Protein Coding gene. Diseases associated with RNASE3 include Allergic Rhinitis and Rhinitis. Among its related pathways are Innate Immune System and Defensins. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE2.
UniProtKB/Swiss-Prot Summary for RNASE3 Gene
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.