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Aliases for RNASE2 Gene

Aliases for RNASE2 Gene

  • Ribonuclease A Family Member 2 2 3 5
  • Eosinophil-Derived Neurotoxin 2 3 4
  • Ribonuclease, RNase A Family, 2 (Liver, Eosinophil-Derived Neurotoxin) 2 3
  • Ribonuclease US 3 4
  • Ribonuclease 2 3 4
  • RNase UpI-2 3 4
  • EC 4 56
  • RNase 2 3 4
  • RNS2 3 4
  • EDN 3 4
  • Non-Secretory Ribonuclease 3
  • Ribonuclease A F3 3
  • RAF3 3

External Ids for RNASE2 Gene

Previous HGNC Symbols for RNASE2 Gene

  • RNS2

Previous GeneCards Identifiers for RNASE2 Gene

  • GC14P018796
  • GC14P015210
  • GC14P019413
  • GC14P020493
  • GC14P021423
  • GC14P001544
  • GC14P021026
  • GC14P021038
  • GC14P021046
  • GC14P021052
  • GC14P021064
  • GC14P021068
  • GC14P021079

Summaries for RNASE2 Gene

Entrez Gene Summary for RNASE2 Gene

  • The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses. [provided by RefSeq, Oct 2014]

GeneCards Summary for RNASE2 Gene

RNASE2 (Ribonuclease A Family Member 2) is a Protein Coding gene. Diseases associated with RNASE2 include Esophagitis, Eosinophilic, 1 and Lacrimoauriculodentodigital Syndrome. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE3.

UniProtKB/Swiss-Prot for RNASE2 Gene

  • This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.

Gene Wiki entry for RNASE2 Gene

Additional gene information for RNASE2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE2 Gene

Genomics for RNASE2 Gene

GeneHancer (GH) Regulatory Elements for RNASE2 Gene

Promoters and enhancers for RNASE2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I020954 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 550.8 -0.1 -51 1.6 GATAD2A NFIA HLF CEBPB CEBPG POLR2A CEBPA HNF4G HNF4A RNASE2 ENSG00000136315 METTL17 SLC39A2 RNASE1 ZNF219 TMEM253 LOC100507513
GH14I020961 Enhancer 0.7 Ensembl 0.4 +5.8 5849 0.6 CTCF RB1 ZNF384 ZNF2 RAD21 ZNF335 E2F1 ZSCAN29 PRDM10 TRIM24 ENSG00000136315 RN7SL189P RNASE2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNASE2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNASE2 gene promoter:

Genomic Locations for RNASE2 Gene

Genomic Locations for RNASE2 Gene
985 bases
Plus strand

Genomic View for RNASE2 Gene

Genes around RNASE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE2 Gene

Proteins for RNASE2 Gene

  • Protein details for RNASE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Non-secretory ribonuclease
    Protein Accession:
    Secondary Accessions:
    • Q52M39
    • Q9H2B7
    • Q9UCG7

    Protein attributes for RNASE2 Gene

    161 amino acids
    Molecular mass:
    18354 Da
    Quaternary structure:
    • Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur.

    Three dimensional structures from OCA and Proteopedia for RNASE2 Gene

neXtProt entry for RNASE2 Gene

Selected DME Specific Peptides for RNASE2 Gene


Post-translational modifications for RNASE2 Gene

  • A particular signal processing and glycosylation pattern may differentiate the UpI2 RNase, found specifically in pregnant women urine, from other nonsecretory RNases.
  • Glycosylation at isoforms=34, Asn44, Asn86, Asn92, Asn111, and isoforms=119
  • Modification sites at PhosphoSitePlus

Other Protein References for RNASE2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for RNASE2 Gene

Gene Families for RNASE2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for RNASE2 Gene

Suggested Antigen Peptide Sequences for RNASE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The N-terminal region is necessary for mediating chemotactic activity.
  • Belongs to the pancreatic ribonuclease family.
  • The N-terminal region is necessary for mediating chemotactic activity.
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE2: view

Function for RNASE2 Gene

Molecular function for RNASE2 Gene

GENATLAS Biochemistry:
ribonuclease RNAse A family,2,eosinophil-derived neurotoxin
UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage to nucleoside 3-phosphates and 3-phosphooligonucleotides ending in Cp or Up with 2,3-cyclic phosphate intermediates.
UniProtKB/Swiss-Prot Function:
This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.

Enzyme Numbers (IUBMB) for RNASE2 Gene

Gene Ontology (GO) - Molecular Function for RNASE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 NOT lipopolysaccharide binding IMP 23992292
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IBA --
GO:0004522 ribonuclease A activity IEA --
genes like me logo Genes that share ontologies with RNASE2: view
genes like me logo Genes that share phenotypes with RNASE2: view

Animal Model Products

CRISPR Products

miRNA for RNASE2 Gene

miRTarBase miRNAs that target RNASE2

Inhibitory RNA Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE2 Gene

Localization for RNASE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE2 Gene

Lysosome. Cytoplasmic granule. Note=Matrix of eosinophils large specific granule.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE2 gene
Compartment Confidence
extracellular 5
lysosome 4
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RNASE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005764 lysosome IEA --
GO:0035578 azurophil granule lumen TAS --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with RNASE2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE2 Gene

Pathways & Interactions for RNASE2 Gene

genes like me logo Genes that share pathways with RNASE2: view

Pathways by source for RNASE2 Gene

3 Reactome pathways for RNASE2 Gene

Gene Ontology (GO) - Biological Process for RNASE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006401 RNA catabolic process TAS 2734298
GO:0006935 chemotaxis IEA,IDA 12855582
GO:0043152 NOT induction of bacterial agglutination IMP 23992292
GO:0043312 neutrophil degranulation TAS --
GO:0050829 NOT defense response to Gram-negative bacterium IMP 23992292
genes like me logo Genes that share ontologies with RNASE2: view

No data available for SIGNOR curated interactions for RNASE2 Gene

Drugs & Compounds for RNASE2 Gene

(2) Drugs for RNASE2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine-2'-5'-Diphosphate Experimental Pharma Target 0
Adenosine-3'-5'-Diphosphate Experimental Pharma Target 0

(1) Additional Compounds for RNASE2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RNASE2: view

Transcripts for RNASE2 Gene

mRNA/cDNA for RNASE2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(34) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNASE2 Gene

Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE2 Gene

No ASD Table

Relevant External Links for RNASE2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNASE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNASE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE2 Gene

This gene is overexpressed in Whole Blood (x42.0).

Protein differential expression in normal tissues from HIPED for RNASE2 Gene

This gene is overexpressed in Urine (34.2), Spleen (7.7), and Neutrophil (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNASE2 Gene

Protein tissue co-expression partners for RNASE2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNASE2 Gene:


SOURCE GeneReport for Unigene cluster for RNASE2 Gene:


mRNA Expression by UniProt/SwissProt for RNASE2 Gene:

Tissue specificity: Liver, lung, spleen, leukocytes and body fluids.

Evidence on tissue expression from TISSUES for RNASE2 Gene

  • Urine(4.4)
  • Intestine(4.3)
  • Liver(4.3)
  • Blood(3.5)
  • Bone marrow(3.1)
  • Lung(2.4)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with RNASE2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE2 Gene

Orthologs for RNASE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNASE2 33 34
  • 98.96 (n)
(Bos Taurus)
Mammalia RNASE3 33
  • 65.82 (n)
-- 34
  • 56 (a)
(Mus musculus)
Mammalia Ear11 33 34
  • 64.57 (n)
Ear6 34
  • 51 (a)
Ear1 34
  • 50 (a)
Ear14 34
  • 50 (a)
Ear5 34
  • 50 (a)
Ear10 34
  • 49 (a)
Ear2 34
  • 48 (a)
Rnase2b 16
(Monodelphis domestica)
Mammalia -- 34
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 27 (a)
(Gallus gallus)
Aves ANG 34
  • 25 (a)
  • 24 (a)
CL2 34
  • 18 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 24 (a)
-- 34
  • 21 (a)
Species where no ortholog for RNASE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE2 Gene

Gene Tree for RNASE2 (if available)
Gene Tree for RNASE2 (if available)

Paralogs for RNASE2 Gene

Paralogs for RNASE2 Gene

(5) SIMAP similar genes for RNASE2 Gene using alignment to 1 proteins: Pseudogenes for RNASE2 Gene

genes like me logo Genes that share paralogs with RNASE2: view

Variants for RNASE2 Gene

Sequence variations from dbSNP and Humsavar for RNASE2 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1001771426 -- 20,954,293(+) T/C upstream_transcript_variant
rs1002111098 -- 20,954,544(+) G/A/T upstream_transcript_variant
rs1003172789 -- 20,955,525(+) C/T 5_prime_UTR_variant
rs1003771626 -- 20,956,882(+) C/G/T downstream_transcript_variant
rs1004228302 -- 20,956,647(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNASE2 Gene

Variant ID Type Subtype PubMed ID
dgv1798n100 CNV gain+loss 25217958
dgv1800n100 CNV gain 25217958
dgv1802n100 CNV loss 25217958
dgv34e203 CNV gain+loss 21179565
dgv3540n54 CNV loss 21841781
esv2759972 CNV gain+loss 17122850
nsv1044554 CNV gain 25217958
nsv1206 CNV insertion 18451855
nsv428293 CNV gain+loss 18775914
nsv456146 CNV loss 19166990
nsv470622 CNV loss 18288195
nsv514732 CNV gain 21397061
nsv527381 CNV gain 19592680
nsv563847 CNV loss 21841781
nsv826880 CNV gain 20364138
nsv826881 CNV gain 20364138
nsv832740 CNV gain 17160897
nsv9121 CNV gain+loss 18304495
nsv983967 CNV duplication 23825009

Variation tolerance for RNASE2 Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE2 Gene

Disorders for RNASE2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RNASE2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
esophagitis, eosinophilic, 1
  • ee
lacrimoauriculodentodigital syndrome
  • ladd
herpes gestationis
  • gestational herpes
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RNASE2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RNASE2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE2 Gene

Publications for RNASE2 Gene

  1. Three single nucleotide polymorphisms leading to non-synonymous amino acid substitution in the human ribonuclease 2 and angiogenin genes exhibit markedly less genetic heterogeneity in six populations. (PMID: 18636464) Ueki M … Yasuda T (Cell biochemistry and function 2008) 3 22 44 58
  2. Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor. (PMID: 15755456) Iyer S … Acharya KR (Journal of molecular biology 2005) 3 4 22 58
  3. Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2). (PMID: 12578357) Teufel DP … Shapiro R (Biochemistry 2003) 3 4 22 58
  4. Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells. (PMID: 12855582) Yang D … Oppenheim JJ (Blood 2003) 3 4 22 58
  5. Sequence variation at two eosinophil-associated ribonuclease loci in humans. (PMID: 11102386) Zhang J … Rosenberg HF (Genetics 2000) 3 4 22 58

Products for RNASE2 Gene

Sources for RNASE2 Gene

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