Aliases for RNASE13 Gene

Aliases for RNASE13 Gene

  • Ribonuclease A Family Member 13 (Inactive) 2 3 5
  • Probable Inactive Ribonuclease-Like Protein 13 3 4
  • Ribonuclease, RNase A Family, 13 (Non-Active) 2 3
  • Epididymis Secretory Sperm Binding Protein Li 86p 3
  • Ribonuclease-Like Protein 13 3
  • Ribonuclease A L1 3
  • Ribonuclease 13 3
  • HEL-S-86p 3
  • RAL1 3

External Ids for RNASE13 Gene

Previous GeneCards Identifiers for RNASE13 Gene

  • GC14M020571
  • GC14M021500
  • GC14M001621

Summaries for RNASE13 Gene

GeneCards Summary for RNASE13 Gene

RNASE13 (Ribonuclease A Family Member 13 (Inactive)) is a Protein Coding gene. Diseases associated with RNASE13 include Amyotrophic Lateral Sclerosis 1. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE8.

UniProtKB/Swiss-Prot Summary for RNASE13 Gene

Additional gene information for RNASE13 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNASE13 Gene

Genomics for RNASE13 Gene

GeneHancer (GH) Regulatory Elements for RNASE13 Gene

Promoters and enhancers for RNASE13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNASE13 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNASE13

Top Transcription factor binding sites by QIAGEN in the RNASE13 gene promoter:
  • c-Rel
  • CREB
  • deltaCREB
  • Nkx2-5
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • RP58
  • Spz1
  • TBP

Genomic Locations for RNASE13 Gene

Genomic Locations for RNASE13 Gene
chr14:21,032,818-21,034,807
(GRCh38/hg38)
Size:
1,990 bases
Orientation:
Minus strand
chr14:21,500,979-21,502,944
(GRCh37/hg19)
Size:
1,966 bases
Orientation:
Minus strand

Genomic View for RNASE13 Gene

Genes around RNASE13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE13 Gene

Proteins for RNASE13 Gene

  • Protein details for RNASE13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5GAN3-RNS13_HUMAN
    Recommended name:
    Probable inactive ribonuclease-like protein 13
    Protein Accession:
    Q5GAN3

    Protein attributes for RNASE13 Gene

    Size:
    156 amino acids
    Molecular mass:
    17845 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASE13 Gene

Post-translational modifications for RNASE13 Gene

  • Glycosylation at Asn126
  • Modification sites at PhosphoSitePlus

Other Protein References for RNASE13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNASE13 Gene

Domains & Families for RNASE13 Gene

Gene Families for RNASE13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RNASE13 Gene

Suggested Antigen Peptide Sequences for RNASE13 Gene

GenScript: Design optimal peptide antigens:
  • Ribonuclease-like protein 13 (RNS13_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5GAN3

UniProtKB/Swiss-Prot:

RNS13_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE13: view

Function for RNASE13 Gene

Molecular function for RNASE13 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit any ribonuclease activity.

Phenotypes From GWAS Catalog for RNASE13 Gene

Gene Ontology (GO) - Molecular Function for RNASE13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004540 NOT ribonuclease activity IKR 15676279
genes like me logo Genes that share ontologies with RNASE13: view

Phenotypes for RNASE13 Gene

genes like me logo Genes that share phenotypes with RNASE13: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE13 Gene

Localization for RNASE13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE13 gene
Compartment Confidence
extracellular 4
plasma membrane 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RNASE13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE13 Gene

Pathways & Interactions for RNASE13 Gene

PathCards logo

SuperPathways for RNASE13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNASE13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with RNASE13: view

No data available for Pathways by source and SIGNOR curated interactions for RNASE13 Gene

Drugs & Compounds for RNASE13 Gene

No Compound Related Data Available

Transcripts for RNASE13 Gene

mRNA/cDNA for RNASE13 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE13 Gene

No ASD Table

Relevant External Links for RNASE13 Gene

GeneLoc Exon Structure for
RNASE13

Expression for RNASE13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNASE13 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE13 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNASE13

SOURCE GeneReport for Unigene cluster for RNASE13 Gene:

Hs.666729

Evidence on tissue expression from TISSUES for RNASE13 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with RNASE13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE13 Gene

Orthologs for RNASE13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNASE13 31 30
  • 99.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RNASE13 31 30
  • 78.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RNASE13 31 30
  • 78 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rnase13 17 31 30
  • 77.56 (n)
rat
(Rattus norvegicus)
Mammalia Rnase13 30
  • 75.6 (n)
oppossum
(Monodelphis domestica)
Mammalia RNASE13 31
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNASE13 31
  • 39 (a)
OneToOne
Species where no ortholog for RNASE13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE13 Gene

ENSEMBL:
Gene Tree for RNASE13 (if available)
TreeFam:
Gene Tree for RNASE13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNASE13: view image

Paralogs for RNASE13 Gene

genes like me logo Genes that share paralogs with RNASE13: view

Variants for RNASE13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNASE13 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs2277847 - p.Ser139Ala

Additional dbSNP identifiers (rs#s) for RNASE13 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNASE13 Gene

Variant ID Type Subtype PubMed ID
nsv1039369 CNV loss 25217958
nsv428293 CNV gain+loss 18775914
nsv832740 CNV gain 17160897

Variation tolerance for RNASE13 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASE13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASE13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE13 Gene

Disorders for RNASE13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNASE13 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RNASE13

genes like me logo Genes that share disorders with RNASE13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE13 Gene

Publications for RNASE13 Gene

  1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S … Zhang J (Genomics 2005) 2 3 4 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. Identification of EGFLAM, SPATC1L and RNASE13 as novel susceptibility loci for aortic aneurysm in Japanese individuals by exome-wide association studies. (PMID: 28339009) Yamada Y … Tanaka M (International journal of molecular medicine 2017) 3 54
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  5. Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M (Molecular genetics and genomics : MGG 2014) 3 54

Products for RNASE13 Gene

Sources for RNASE13 Gene