Aliases for RNASE13 Gene

Aliases for RNASE13 Gene

  • Ribonuclease A Family Member 13 (Inactive) 2 3 5
  • Probable Inactive Ribonuclease-Like Protein 13 3 4
  • Ribonuclease, RNase A Family, 13 (Non-Active) 2 3
  • RAL1 2 3
  • Epididymis Secretory Sperm Binding Protein Li 86p 3
  • Ribonuclease-Like Protein 13 3
  • Ribonuclease A L1 3
  • Ribonuclease 13 3
  • HEL-S-86p 3
  • RNASE13 5

External Ids for RNASE13 Gene

Previous GeneCards Identifiers for RNASE13 Gene

  • GC14M020571
  • GC14M021500
  • GC14M001621

Summaries for RNASE13 Gene

GeneCards Summary for RNASE13 Gene

RNASE13 (Ribonuclease A Family Member 13 (Inactive)) is a Protein Coding gene. Diseases associated with RNASE13 include Amyotrophic Lateral Sclerosis 1. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE7.

UniProtKB/Swiss-Prot Summary for RNASE13 Gene

Additional gene information for RNASE13 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNASE13 Gene

Genomics for RNASE13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RNASE13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J021031 Enhancer 0.3 Ensembl 600.7 +1.6 1606 2.8 EGR2 ENSG00000255472 RNASE13 TPPP2 ENSG00000258604 NDRG2
GH14J021068 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.4 -36.2 -36170 5.2 HNRNPL GATAD2A CTCF PRDM10 ZNF629 ZNF512 IKZF1 ZNF692 LARP7 PRDM1 ARHGEF40 NDRG2 TMEM253 ZNF219 RNASE7 TPPP2 ENSG00000255472 RNASE13 RNASE6 TOX4
GH14J020997 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 10.8 +36.1 36122 2.9 ZNF629 PRDM10 ZIC2 ZNF600 ZNF561 SCRT2 SP2 SMARCC1 ZBTB17 SCRT1 SLC39A2 LOC101929718 TPPP2 ENSG00000255472 RNASE13 ZNF219 TMEM253 RNASE7 NONHSAG014393.2 METTL17
GH14J020705 Promoter/Enhancer 1.1 Ensembl ENCODE 9.6 +328.1 328106 3.8 ZHX2 SOX6 ZNF766 CTBP1 ZNF217 RAD51 TEAD3 NANOG SMARCE1 SP1 piR-30188-060 ANG EDDM3B RNASE1 METTL17 ZNF219 TPPP2 ENSG00000255472 RNASE13 RNA5SP382
GH14J021191 Enhancer 0.8 ENCODE 9.9 -157.4 -157426 0.9 PRDM10 ZHX2 ZIC2 PATZ1 ZNF600 YY1 ZNF341 ZNF561 ZBTB44 KLF9 OR5AU1 ZNF219 TMEM253 ENSG00000255472 RNASE13 TPPP2 piR-54764-162 lnc-RPGRIP1-2 HNRNPC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNASE13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNASE13

Top Transcription factor binding sites by QIAGEN in the RNASE13 gene promoter:
  • c-Rel
  • CREB
  • deltaCREB
  • Nkx2-5
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • RP58
  • Spz1
  • TBP

Genomic Locations for RNASE13 Gene

Genomic Locations for RNASE13 Gene
1,990 bases
Minus strand
1,966 bases
Minus strand

Genomic View for RNASE13 Gene

Genes around RNASE13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE13 Gene

Proteins for RNASE13 Gene

  • Protein details for RNASE13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable inactive ribonuclease-like protein 13
    Protein Accession:

    Protein attributes for RNASE13 Gene

    156 amino acids
    Molecular mass:
    17845 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNASE13 Gene

Post-translational modifications for RNASE13 Gene

  • Glycosylation at Asn126
  • Modification sites at PhosphoSitePlus

Other Protein References for RNASE13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNASE13 Gene

Domains & Families for RNASE13 Gene

Gene Families for RNASE13 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for RNASE13 Gene

Suggested Antigen Peptide Sequences for RNASE13 Gene

GenScript: Design optimal peptide antigens:
  • Ribonuclease-like protein 13 (RNS13_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pancreatic ribonuclease family.
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE13: view

Function for RNASE13 Gene

Molecular function for RNASE13 Gene

UniProtKB/Swiss-Prot Function:
Does not exhibit any ribonuclease activity.

Phenotypes From GWAS Catalog for RNASE13 Gene

Gene Ontology (GO) - Molecular Function for RNASE13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004540 NOT ribonuclease activity IBA, IKR 15676279
genes like me logo Genes that share ontologies with RNASE13: view

Phenotypes for RNASE13 Gene

genes like me logo Genes that share phenotypes with RNASE13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNASE13 Gene

Localization for RNASE13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE13 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE13 gene
Compartment Confidence
extracellular 4
plasma membrane 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RNASE13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE13: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE13 Gene

Pathways & Interactions for RNASE13 Gene

PathCards logo

SuperPathways for RNASE13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNASE13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with RNASE13: view

No data available for Pathways by source and SIGNOR curated interactions for RNASE13 Gene

Drugs & Compounds for RNASE13 Gene

No Compound Related Data Available

Transcripts for RNASE13 Gene

mRNA/cDNA for RNASE13 Gene

3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE13

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE13 Gene

No ASD Table

Relevant External Links for RNASE13 Gene

GeneLoc Exon Structure for

Expression for RNASE13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNASE13 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE13 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNASE13

SOURCE GeneReport for Unigene cluster for RNASE13 Gene:


Evidence on tissue expression from TISSUES for RNASE13 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RNASE13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE13 Gene

Orthologs for RNASE13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNASE13 30 31
  • 99.36 (n)
(Canis familiaris)
Mammalia RNASE13 30 31
  • 78.43 (n)
(Bos Taurus)
Mammalia RNASE13 30 31
  • 78 (n)
(Mus musculus)
Mammalia Rnase13 30 17 31
  • 77.56 (n)
(Rattus norvegicus)
Mammalia Rnase13 30
  • 75.6 (n)
(Monodelphis domestica)
Mammalia RNASE13 31
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia RNASE13 31
  • 39 (a)
Species where no ortholog for RNASE13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RNASE13 Gene

Gene Tree for RNASE13 (if available)
Gene Tree for RNASE13 (if available)
Evolutionary constrained regions (ECRs) for RNASE13: view image

Paralogs for RNASE13 Gene

genes like me logo Genes that share paralogs with RNASE13: view

Variants for RNASE13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNASE13 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs2277847 - p.Ser139Ala

Additional dbSNP identifiers (rs#s) for RNASE13 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNASE13 Gene

Variant ID Type Subtype PubMed ID
nsv1039369 CNV loss 25217958
nsv428293 CNV gain+loss 18775914
nsv832740 CNV gain 17160897

Variation tolerance for RNASE13 Gene

Residual Variation Intolerance Score: 83.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.90; 35.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASE13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE13 Gene

Disorders for RNASE13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNASE13 Gene - From: DISEASES

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • als1
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with RNASE13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE13 Gene

Publications for RNASE13 Gene

  1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S … Zhang J (Genomics 2005) 2 3 4
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. Identification of EGFLAM, SPATC1L and RNASE13 as novel susceptibility loci for aortic aneurysm in Japanese individuals by exome-wide association studies. (PMID: 28339009) Yamada Y … Tanaka M (International journal of molecular medicine 2017) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  5. Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M (Molecular genetics and genomics : MGG 2014) 3

Products for RNASE13 Gene

Sources for RNASE13 Gene