Aliases for RNASE10 Gene

Aliases for RNASE10 Gene

  • Ribonuclease A Family Member 10 (Inactive) 2 3 5
  • Ribonuclease, RNase A Family, 10 (Non-Active) 2 3
  • Inactive Ribonuclease-Like Protein 10 3 4
  • Ribonuclease A H1 3
  • RNASE9 3
  • RAH1 3

External Ids for RNASE10 Gene

Previous GeneCards Identifiers for RNASE10 Gene

  • GC14P020049
  • GC14P021022
  • GC14P001099
  • GC14P021023
  • GC14P021027
  • GC14P021030
  • GC14P021034
  • GC14P021037

Summaries for RNASE10 Gene

GeneCards Summary for RNASE10 Gene

RNASE10 (Ribonuclease A Family Member 10 (Inactive)) is a Protein Coding gene. Diseases associated with RNASE10 include Hypotrichosis 6 and Orchitis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease activity. An important paralog of this gene is RNASE7.

UniProtKB/Swiss-Prot Summary for RNASE10 Gene

  • Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity).

Additional gene information for RNASE10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNASE10 Gene

Genomics for RNASE10 Gene

GeneHancer (GH) Regulatory Elements for RNASE10 Gene

Promoters and enhancers for RNASE10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNASE10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNASE10

Top Transcription factor binding sites by QIAGEN in the RNASE10 gene promoter:
  • AML1a
  • NF-1
  • NF-1/L
  • PPAR-gamma2
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for RNASE10 Gene

Genomic Locations for RNASE10 Gene
chr14:20,505,537-20,511,169
(GRCh38/hg38)
Size:
5,633 bases
Orientation:
Plus strand
chr14:20,973,696-20,979,328
(GRCh37/hg19)
Size:
5,633 bases
Orientation:
Plus strand

Genomic View for RNASE10 Gene

Genes around RNASE10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE10 Gene

Proteins for RNASE10 Gene

  • Protein details for RNASE10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5GAN6-RNS10_HUMAN
    Recommended name:
    Inactive ribonuclease-like protein 10
    Protein Accession:
    Q5GAN6
    Secondary Accessions:
    • A2RUQ3
    • B4DKY4

    Protein attributes for RNASE10 Gene

    Size:
    216 amino acids
    Molecular mass:
    24008 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNASE10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNASE10 Gene

Post-translational modifications for RNASE10 Gene

Other Protein References for RNASE10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNASE10 Gene

Domains & Families for RNASE10 Gene

Gene Families for RNASE10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for RNASE10 Gene

Suggested Antigen Peptide Sequences for RNASE10 Gene

GenScript: Design optimal peptide antigens:
  • Ribonuclease-like protein 10 (RNS10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5GAN6

UniProtKB/Swiss-Prot:

RNS10_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE10: view

Function for RNASE10 Gene

Molecular function for RNASE10 Gene

UniProtKB/Swiss-Prot Function:
Secreted proximal epididymal protein required for post-testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity).

Phenotypes From GWAS Catalog for RNASE10 Gene

Gene Ontology (GO) - Molecular Function for RNASE10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004540 NOT ribonuclease activity IKR 15676279
genes like me logo Genes that share ontologies with RNASE10: view
genes like me logo Genes that share phenotypes with RNASE10: view

Animal Models for RNASE10 Gene

MGI Knock Outs for RNASE10:
  • Rnase10 Rnase10<tm1a(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for RNASE10 Gene

miRTarBase miRNAs that target RNASE10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNASE10 Gene

Localization for RNASE10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE10 gene
Compartment Confidence
extracellular 4
plasma membrane 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RNASE10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RNASE10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNASE10 Gene

Pathways & Interactions for RNASE10 Gene

PathCards logo

SuperPathways for RNASE10 Gene

No Data Available

Interacting Proteins for RNASE10 Gene

;

Gene Ontology (GO) - Biological Process for RNASE10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007338 single fertilization IEA --
GO:0022409 positive regulation of cell-cell adhesion ISS --
GO:0034113 heterotypic cell-cell adhesion ISS --
GO:0080154 regulation of fertilization ISS --
genes like me logo Genes that share ontologies with RNASE10: view

No data available for Pathways by source and SIGNOR curated interactions for RNASE10 Gene

Drugs & Compounds for RNASE10 Gene

No Compound Related Data Available

Transcripts for RNASE10 Gene

mRNA/cDNA for RNASE10 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE10 Gene

No ASD Table

Relevant External Links for RNASE10 Gene

GeneLoc Exon Structure for
RNASE10

Expression for RNASE10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNASE10 Gene

mRNA differential expression in normal tissues according to GTEx for RNASE10 Gene

This gene is overexpressed in Testis (x4.3).

Protein differential expression in normal tissues from HIPED for RNASE10 Gene

This gene is overexpressed in Plasma (47.2) and Heart (21.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE10 Gene



Protein tissue co-expression partners for RNASE10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNASE10

SOURCE GeneReport for Unigene cluster for RNASE10 Gene:

Hs.451057
genes like me logo Genes that share expression patterns with RNASE10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE10 Gene

Orthologs for RNASE10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNASE10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNASE10 31 30
  • 98.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RNASE10 31 30
  • 79.46 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnase10 30
  • 77.08 (n)
mouse
(Mus musculus)
Mammalia Rnase10 17 31 30
  • 76.65 (n)
dog
(Canis familiaris)
Mammalia RNASE10 31 30
  • 75.86 (n)
OneToOne
Species where no ortholog for RNASE10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE10 Gene

ENSEMBL:
Gene Tree for RNASE10 (if available)
TreeFam:
Gene Tree for RNASE10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNASE10: view image

Paralogs for RNASE10 Gene

genes like me logo Genes that share paralogs with RNASE10: view

Variants for RNASE10 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNASE10 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs2067648 - p.Ser131Asn

Additional dbSNP identifiers (rs#s) for RNASE10 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNASE10 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545

Variation tolerance for RNASE10 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASE10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASE10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE10 Gene

Disorders for RNASE10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RNASE10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypotrichosis 6
  • hypt6
orchitis
  • inflammation of testis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RNASE10

genes like me logo Genes that share disorders with RNASE10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE10 Gene

Publications for RNASE10 Gene

  1. The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. (PMID: 15676279) Cho S … Zhang J (Genomics 2005) 2 3 4 54
  2. Discovery in silico and characterization in vitro of novel genes exclusively expressed in the mouse epididymis. (PMID: 12920233) Penttinen J … Poutanen M (Molecular endocrinology (Baltimore, Md.) 2003) 2 3 54
  3. Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients. (PMID: 24811271) Kennedy RB … Poland GA (Immunogenetics 2014) 3 54
  4. Comparative genomic analysis of eutherian ribonuclease A genes. (PMID: 24337645) Premzl M (Molecular genetics and genomics : MGG 2014) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for RNASE10 Gene

Sources for RNASE10 Gene