This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly a... See more...

Aliases for RNASE1 Gene

Aliases for RNASE1 Gene

  • Ribonuclease A Family Member 1, Pancreatic 2 3 5
  • Ribonuclease, RNase A Family, 1 (Pancreatic) 2 3
  • Ribonuclease Pancreatic 3 4
  • Ribonuclease 1 3 4
  • RNase UpI-1 3 4
  • HP-RNase 3 4
  • RNase 1 3 4
  • RNase A 3 4
  • RIB-1 3 4
  • RAC1 2 3
  • RIB1 3 4
  • RNS1 3 4
  • Ribonuclease A C1 3
  • Ribonuclease A 4
  • EC 3.1.27.5 50
  • EC 4.6.1.18 4
  • RNASE1 5

External Ids for RNASE1 Gene

Previous HGNC Symbols for RNASE1 Gene

  • RNS1

Previous GeneCards Identifiers for RNASE1 Gene

  • GC14M018641
  • GC14M015056
  • GC14M019259
  • GC14M020339
  • GC14M021269
  • GC14M001390

Summaries for RNASE1 Gene

Entrez Gene Summary for RNASE1 Gene

  • This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNASE1 Gene

RNASE1 (Ribonuclease A Family Member 1, Pancreatic) is a Protein Coding gene. Diseases associated with RNASE1 include Mesothelioma, Malignant and Lynch Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease A activity. An important paralog of this gene is RNASE4.

UniProtKB/Swiss-Prot Summary for RNASE1 Gene

  • Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.

Gene Wiki entry for RNASE1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNASE1 Gene

Genomics for RNASE1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RNASE1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020798 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.9 1949 5.6 IKZF1 NCOR1 ZNF592 NFIC ARNT TAF9B TAL1 ZNF316 TEAD3 NFE2 EGILA LOC107984671 RNASE1 OR11H7 lnc-RNASE6-2 LOC105370397 RNASE6
GH14J020827 Promoter/Enhancer 1 EPDnew ENCODE 262 -25.2 -25170 0.8 NFIC POLR2A SIN3A ZNF585B CTCF ZBTB40 PKNOX1 TAF1 ZBTB33 SP1 RNASE1 ENSG00000258515 SUPT16H METTL3 METTL17 RAB2B ENSG00000258768 OSGEP TTC5 EDDM3A
GH14J020779 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 11.5 +20.8 20806 4.2 BCLAF1 SP1 BCL11A GABPA IRF4 CBFB MAX SPI1 SRF BATF ENSG00000258810 HSALNG0099826 RNASE6 RNASE1 LOC107984671 EGILA
GH14J020855 Enhancer 1 Ensembl ENCODE 11.2 -52.9 -52946 0.8 ZNF654 ZNF592 ZNF10 CTCF REST TRIM22 BHLHE40 MNT SIN3A RAD51 RNASE1 EDDM3A piR-48222-117 piR-32214-163 ENSG00000259130 RNASE3
GH14J020705 Promoter/Enhancer 0.9 Ensembl ENCODE 11 +95.7 95724 2.6 ZNF217 CTBP1 TEAD3 SMARCE1 RAD51 SP1 POU5F1 NANOG ZHX2 SOX6 piR-30188-060 ANG EDDM3B RNASE1 METTL17 ZNF219 TPPP2 ENSG00000255472 RNASE13 RNA5SP382
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNASE1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNASE1

Top Transcription factor binding sites by QIAGEN in the RNASE1 gene promoter:
  • AREB6
  • COMP1
  • ER-alpha
  • Lmo2
  • S8

Genomic Locations for RNASE1 Gene

Latest Assembly
chr14:20,801,228-20,802,855
(GRCh38/hg38)
Size:
1,628 bases
Orientation:
Minus strand

Previous Assembly
chr14:21,269,387-21,271,003
(GRCh37/hg19 by Entrez Gene)
Size:
1,617 bases
Orientation:
Minus strand

chr14:21,269,387-21,271,437
(GRCh37/hg19 by Ensembl)
Size:
2,051 bases
Orientation:
Minus strand

Genomic View for RNASE1 Gene

Genes around RNASE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE1 Gene

Proteins for RNASE1 Gene

  • Protein details for RNASE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07998-RNAS1_HUMAN
    Recommended name:
    Ribonuclease pancreatic
    Protein Accession:
    P07998
    Secondary Accessions:
    • B2R589
    • D3DS06
    • Q16830
    • Q16869
    • Q1KHR2
    • Q6ICS5
    • Q9UCB4
    • Q9UCB5

    Protein attributes for RNASE1 Gene

    Size:
    156 amino acids
    Molecular mass:
    17644 Da
    Quaternary structure:
    • Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein.

    Three dimensional structures from OCA and Proteopedia for RNASE1 Gene

neXtProt entry for RNASE1 Gene

Selected DME Specific Peptides for RNASE1 Gene

P07998:
  • RRNMTQG
  • CRLTNGS
  • IIVACEG
  • PYVPVHFD
  • ESRAKKFQRQH
  • VNTFVHE
  • LVLGWVQPSLG
  • CKPVNTF
  • MHITDCR
  • QEKVTCKNG
  • TYCNQMM
  • KFQRQHMD
  • VPVHFDA

Post-translational modifications for RNASE1 Gene

  • N-linked glycans are of complex type.
  • Glycosylation at Asn62, Asn104, and Asn116
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • RNAS1_HUMAN (1973)

Other Protein References for RNASE1 Gene

Domains & Families for RNASE1 Gene

Gene Families for RNASE1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for RNASE1 Gene

InterPro:
Blocks:
  • Pancreatic ribonuclease

Suggested Antigen Peptide Sequences for RNASE1 Gene

GenScript: Design optimal peptide antigens:
  • Ribonuclease A (RNAS1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P07998

UniProtKB/Swiss-Prot:

RNAS1_HUMAN :
  • Belongs to the pancreatic ribonuclease family.
Family:
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE1: view

Function for RNASE1 Gene

Molecular function for RNASE1 Gene

UniProtKB/Swiss-Prot Function:
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=An (RNA) containing cytidine + H(2)O = an (RNA)-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA).; EC=4.6.1.18;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=An (RNA) containing uridine + H(2)O = an (RNA)-3'-uridine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-(RNA).; EC=4.6.1.18;.
GENATLAS Biochemistry:
ribonuclease RNAse A family,1,secretory,pancreatic with a dimeric mutant selectively cytotoxic for malignant cells

Enzyme Numbers (IUBMB) for RNASE1 Gene

Phenotypes From GWAS Catalog for RNASE1 Gene

Gene Ontology (GO) - Molecular Function for RNASE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IEA --
GO:0004522 ribonuclease A activity TAS,IEA --
GO:0004540 ribonuclease activity IBA,IDA 9826755
genes like me logo Genes that share ontologies with RNASE1: view
genes like me logo Genes that share phenotypes with RNASE1: view

Animal Models for RNASE1 Gene

MGI Knock Outs for RNASE1:

miRNA for RNASE1 Gene

miRTarBase miRNAs that target RNASE1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE1

Clone products for research

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNASE1 Gene

Localization for RNASE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNASE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with RNASE1: view

Pathways & Interactions for RNASE1 Gene

PathCards logo

SuperPathways for RNASE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNASE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051607 NOT defense response to virus IDA 9826755
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:0090501 RNA phosphodiester bond hydrolysis IDA 9826755
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RNASE1: view

No data available for Pathways by source and SIGNOR curated interactions for RNASE1 Gene

Drugs & Compounds for RNASE1 Gene

(66) Drugs for RNASE1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanidine Approved Pharma Target 0
Aspartic acid Approved Nutra Target 195
Citric acid Approved, Vet_approved Nutra Target 1606
Isopropyl alcohol Approved, Investigational Pharma 0
tert-butanol Experimental Pharma Target 0

(55) Additional Compounds for RNASE1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RNASE1: view

Transcripts for RNASE1 Gene

mRNA/cDNA for RNASE1 Gene

4 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for RNASE1 Gene

GeneLoc Exon Structure for
RNASE1

Expression for RNASE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNASE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE1 Gene

This gene is overexpressed in Pancreas (x5.1).

Protein differential expression in normal tissues from HIPED for RNASE1 Gene

This gene is overexpressed in Urine (18.3), Cerebrospinal fluid (14.0), Plasma (10.5), Saliva (7.7), and Pancreatic juice (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNASE1

SOURCE GeneReport for Unigene cluster for RNASE1 Gene:

Hs.78224

mRNA Expression by UniProt/SwissProt for RNASE1 Gene:

P07998-RNAS1_HUMAN
Tissue specificity: Pancreas and other tissues and body fluids (indicating it may have other physiological functions besides its role in digestion).

Evidence on tissue expression from TISSUES for RNASE1 Gene

  • Pancreas(4.8)
  • Nervous system(4.5)
  • Urine(4.2)
  • Lung(3.9)
  • Stomach(3.5)
  • Heart(3.2)
  • Muscle(3)
  • Spleen(3)
  • Kidney(3)
  • Intestine(2.9)
  • Adrenal gland(2.9)
  • Lymph node(2.8)
  • Skin(2.7)
  • Eye(2.6)
  • Liver(2.5)
  • Gall bladder(2.4)
  • Thyroid gland(2.4)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with RNASE1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE1 Gene

Orthologs for RNASE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RNASE1 29 30
  • 98.72 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rnase1 29 16 30
  • 81.06 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RNASE1 29 30
  • 78.97 (n)
OneToMany
SRN 30
  • 74 (a)
OneToMany
BRN 30
  • 65 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LOC475395 29
  • 75.39 (n)
RNASE1 30
  • 64 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rnase1 29
  • 75 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 61 (a)
OneToMany
-- 30
  • 43 (a)
OneToMany
-- 30
  • 38 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 32 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves RSFR 30
  • 32 (a)
ManyToMany
CL2 30
  • 31 (a)
ManyToMany
ANG 30
  • 29 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 41 (a)
ManyToMany
-- 30
  • 30 (a)
ManyToMany
Species where no ortholog for RNASE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RNASE1 Gene

ENSEMBL:
Gene Tree for RNASE1 (if available)
TreeFam:
Gene Tree for RNASE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNASE1: view image
Alliance of Genome Resources:
Additional Orthologs for RNASE1

Paralogs for RNASE1 Gene

(7) SIMAP similar genes for RNASE1 Gene using alignment to 2 proteins:

  • RNAS1_HUMAN
  • G3V357_HUMAN
genes like me logo Genes that share paralogs with RNASE1: view

Variants for RNASE1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RNASE1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RNASE1 Gene

Variant ID Type Subtype PubMed ID
esv2759972 CNV gain+loss 17122850
nsv428293 CNV gain+loss 18775914

Variation tolerance for RNASE1 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNASE1
Leiden Open Variation Database (LOVD)
RNASE1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNASE1 Gene

Disorders for RNASE1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RNASE1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
mesothelioma, malignant
  • mesom
lynch syndrome
  • coca 1
noonan syndrome 1
  • ns1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RNASE1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RNASE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE1 Gene

Publications for RNASE1 Gene

  1. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. (PMID: 17350650) Johnson RJ … Raines RT (Journal of molecular biology 2007) 3 4 22
  2. Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases. (PMID: 11021969) Pous J … Coll M (Journal of molecular biology 2000) 3 4 22
  3. [Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location]. (PMID: 8588814) Kochetov AV … Rivkin MI (Bioorganicheskaia khimiia 1995) 2 3 4
  4. Development of genotyping methods for single nucleotide polymorphism in the human pancreatic ribonuclease gene (RNASE1) and their application to population studies. (PMID: 18219569) Ueki M … Yasuda T (Biochemical genetics 2008) 3 22
  5. The solution structure and dynamics of human pancreatic ribonuclease determined by NMR spectroscopy provide insight into its remarkable biological activities and inhibition. (PMID: 18495155) Kövér KE … Rico M (Journal of molecular biology 2008) 3 22

Products for RNASE1 Gene

Sources for RNASE1 Gene