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Aliases for RNASE1 Gene

Aliases for RNASE1 Gene

  • Ribonuclease A Family Member 1, Pancreatic 2 3 5
  • Ribonuclease, RNase A Family, 1 (Pancreatic) 2 3
  • Ribonuclease 1 3 4
  • RNase UpI-1 3 4
  • HP-RNase 3 4
  • RNase 1 3 4
  • RNase A 3 4
  • RIB-1 3 4
  • RNS1 3 4
  • RIB1 3 4
  • Ribonuclease Pancreatic 3
  • Ribonuclease A C1 3
  • Ribonuclease A 4
  • EC 4
  • RAC1 3

External Ids for RNASE1 Gene

Previous HGNC Symbols for RNASE1 Gene

  • RNS1

Previous GeneCards Identifiers for RNASE1 Gene

  • GC14M018641
  • GC14M015056
  • GC14M019259
  • GC14M020339
  • GC14M021269
  • GC14M001390

Summaries for RNASE1 Gene

Entrez Gene Summary for RNASE1 Gene

  • This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNASE1 Gene

RNASE1 (Ribonuclease A Family Member 1, Pancreatic) is a Protein Coding gene. Diseases associated with RNASE1 include St. Louis Encephalitis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and ribonuclease A activity. An important paralog of this gene is RNASE4.

UniProtKB/Swiss-Prot for RNASE1 Gene

  • Endonuclease that catalyzes the cleavage of RNA on the 3 side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.

Gene Wiki entry for RNASE1 Gene

Additional gene information for RNASE1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNASE1 Gene

Genomics for RNASE1 Gene

GeneHancer (GH) Regulatory Elements for RNASE1 Gene

Promoters and enhancers for RNASE1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J020798 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +2.4 2372 5.6 PKNOX1 ATF1 ARNT NCOA2 YY1 TCF12 ZNF766 NCOA1 ZNF592 ZNF184 RNASE1 OR11H7 LOC105370397
GH14J020827 Promoter/Enhancer 1.2 EPDnew ENCODE 662 -24.7 -24747 0.8 CTCF PKNOX1 USF1 BACH1 SIN3A ZBTB40 ZNF280A CBX5 RBAK ZNF26 RNASE1 ENSG00000258515 SUPT16H METTL3 METTL17 RAB2B ENSG00000258768 OSGEP TTC5 EDDM3A
GH14J020779 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 11.4 +21.2 21229 4.2 PKNOX1 BACH1 STAT5A BATF IRF4 POLR2A NFATC1 EED ETV6 BCLAF1 ENSG00000258810 RNASE6 RNASE1
GH14J020954 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 10.6 -152.1 -152123 1.6 GATAD2A NFIA HLF CEBPB CEBPG POLR2A CEBPA HNF4G HNF4A RNASE2 ENSG00000136315 METTL17 SLC39A2 RNASE1 ZNF219 TMEM253 LOC100507513
GH14J020714 Enhancer 1.1 FANTOM5 Ensembl ENCODE 11.2 +87.9 87872 2.5 CTCF NFIB FEZF1 ZEB2 ZIC2 OSR2 ZNF335 RBAK POLR2A GLIS1 EDDM3A RNASE6 ENSG00000258515 METTL3 SUPT16H METTL17 EDDM3B RNASE1 ANG ARHGEF40
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNASE1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNASE1 gene promoter:
  • COMP1
  • ER-alpha
  • AREB6
  • Lmo2
  • S8

Genomic Locations for RNASE1 Gene

Genomic Locations for RNASE1 Gene
2,051 bases
Minus strand
2,051 bases
Minus strand

Genomic View for RNASE1 Gene

Genes around RNASE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNASE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNASE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNASE1 Gene

Proteins for RNASE1 Gene

  • Protein details for RNASE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribonuclease pancreatic
    Protein Accession:
    Secondary Accessions:
    • B2R589
    • D3DS06
    • Q16830
    • Q16869
    • Q1KHR2
    • Q6ICS5
    • Q9UCB4
    • Q9UCB5

    Protein attributes for RNASE1 Gene

    156 amino acids
    Molecular mass:
    17644 Da
    Quaternary structure:
    • Monomer. Interacts with and forms tight 1:1 complexes with RNH1. Dimerization of two such complexes may occur. Interaction with RNH1 inhibits this protein.

    Three dimensional structures from OCA and Proteopedia for RNASE1 Gene

neXtProt entry for RNASE1 Gene

Post-translational modifications for RNASE1 Gene

  • N-linked glycans are of complex type.
  • Glycosylation at posLast=116116, posLast=104104, and posLast=6262
  • Modification sites at PhosphoSitePlus

Other Protein References for RNASE1 Gene

No data available for DME Specific Peptides for RNASE1 Gene

Domains & Families for RNASE1 Gene

Gene Families for RNASE1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for RNASE1 Gene

Suggested Antigen Peptide Sequences for RNASE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the pancreatic ribonuclease family.
  • Belongs to the pancreatic ribonuclease family.
genes like me logo Genes that share domains with RNASE1: view

Function for RNASE1 Gene

Molecular function for RNASE1 Gene

UniProtKB/Swiss-Prot Function:
Endonuclease that catalyzes the cleavage of RNA on the 3 side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.
UniProtKB/Swiss-Prot CatalyticActivity:
Endonucleolytic cleavage to nucleoside 3-phosphates and 3-phosphooligonucleotides ending in Cp or Up with 2,3-cyclic phosphate intermediates.
GENATLAS Biochemistry:
ribonuclease RNAse A family,1,secretory,pancreatic with a dimeric mutant selectively cytotoxic for malignant cells

Enzyme Numbers (IUBMB) for RNASE1 Gene

Phenotypes From GWAS Catalog for RNASE1 Gene

Gene Ontology (GO) - Molecular Function for RNASE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004518 nuclease activity IEA --
GO:0004519 endonuclease activity IBA --
GO:0004522 ribonuclease A activity IEA,TAS --
GO:0004540 ribonuclease activity IBA,IDA 9826755
genes like me logo Genes that share ontologies with RNASE1: view
genes like me logo Genes that share phenotypes with RNASE1: view

Animal Model Products

CRISPR Products

miRNA for RNASE1 Gene

miRTarBase miRNAs that target RNASE1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNASE1 Gene

Localization for RNASE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNASE1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNASE1 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNASE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with RNASE1: view

Pathways & Interactions for RNASE1 Gene

SuperPathways for RNASE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNASE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051607 NOT defense response to virus IDA 9826755
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:0090501 RNA phosphodiester bond hydrolysis IDA 9826755
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with RNASE1: view

No data available for Pathways by source and SIGNOR curated interactions for RNASE1 Gene

Drugs & Compounds for RNASE1 Gene

(63) Drugs for RNASE1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanidine Approved Pharma Target 0
Isopropyl alcohol Approved, Investigational Pharma Target 0
Citric Acid Approved, Vet_approved Nutra Agonist, Activator, Target 1243
L-Aspartic acid Approved Nutra Target 0
Formic acid Approved, Experimental, Investigational Pharma Target 0

(60) Additional Compounds for RNASE1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (CH3)3C-OH
  • 1,1-Dimethylethanol
  • t-Butanol
  • t-Butyl alchohol
  • t-Butylalkohol
genes like me logo Genes that share compounds with RNASE1: view

Transcripts for RNASE1 Gene

mRNA/cDNA for RNASE1 Gene

Unigene Clusters for RNASE1 Gene

Ribonuclease, RNase A family, 1 (pancreatic):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNASE1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNASE1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d
SP1: -
SP2: - -
SP3: - - -

Relevant External Links for RNASE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNASE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNASE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNASE1 Gene

This gene is overexpressed in Pancreas (x5.1).

Protein differential expression in normal tissues from HIPED for RNASE1 Gene

This gene is overexpressed in Urine (18.3), Cerebrospinal fluid (14.0), Plasma (10.5), Saliva (7.7), and Pancreatic juice (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNASE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNASE1 Gene:


SOURCE GeneReport for Unigene cluster for RNASE1 Gene:


mRNA Expression by UniProt/SwissProt for RNASE1 Gene:

Tissue specificity: Pancreas and other tissues and body fluids (indicating it may have other physiological functions besides its role in digestion).

Evidence on tissue expression from TISSUES for RNASE1 Gene

  • Pancreas(4.7)
  • Nervous system(4.4)
  • Urine(4.2)
  • Lung(3.7)
  • Stomach(3.3)
  • Heart(2.8)
  • Spleen(2.6)
  • Muscle(2.5)
  • Adrenal gland(2.4)
  • Gall bladder(2.4)
  • Kidney(2.4)
  • Eye(2)
  • Liver(2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with RNASE1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNASE1 Gene

Orthologs for RNASE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNASE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNASE1 34 33
  • 98.72 (n)
(Mus musculus)
Mammalia Rnase1 16 34 33
  • 81.06 (n)
(Bos Taurus)
Mammalia RNASE1 34 33
  • 78.97 (n)
SRN 34
  • 74 (a)
BRN 34
  • 65 (a)
(Canis familiaris)
Mammalia LOC475395 33
  • 75.39 (n)
  • 64 (a)
(Rattus norvegicus)
Mammalia Rnase1 33
  • 75 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 61 (a)
-- 34
  • 43 (a)
-- 34
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 32 (a)
(Gallus gallus)
Aves RSFR 34
  • 32 (a)
CL2 34
  • 31 (a)
ANG 34
  • 29 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 41 (a)
-- 34
  • 30 (a)
Species where no ortholog for RNASE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNASE1 Gene

Gene Tree for RNASE1 (if available)
Gene Tree for RNASE1 (if available)
Evolutionary constrained regions (ECRs) for RNASE1: view image

Paralogs for RNASE1 Gene

Paralogs for RNASE1 Gene

(7) SIMAP similar genes for RNASE1 Gene using alignment to 2 proteins:

  • G3V357_HUMAN
genes like me logo Genes that share paralogs with RNASE1: view

Variants for RNASE1 Gene

Sequence variations from dbSNP and Humsavar for RNASE1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000195821 -- 20,804,296(-) A/G upstream_transcript_variant
rs1000550363 -- 20,800,882(-) C/A downstream_transcript_variant
rs1001354929 -- 20,803,509(-) GTTCTTATCTACAGT/GT upstream_transcript_variant
rs1001553639 -- 20,802,766(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001584779 -- 20,802,268(-) C/G 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNASE1 Gene

Variant ID Type Subtype PubMed ID
esv2759972 CNV gain+loss 17122850
nsv428293 CNV gain+loss 18775914

Variation tolerance for RNASE1 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNASE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNASE1 Gene

Disorders for RNASE1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNASE1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
st. louis encephalitis
  • neuroinvasive st. louis encephalitis virus infection
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RNASE1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RNASE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNASE1 Gene

Publications for RNASE1 Gene

  1. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. (PMID: 17350650) Johnson RJ … Raines RT (Journal of molecular biology 2007) 3 4 22 58
  2. Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases. (PMID: 11021969) Pous J … Coll M (Journal of molecular biology 2000) 3 4 22 58
  3. [Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location]. (PMID: 8588814) Kochetov AV … Rivkin MI (Bioorganicheskaia khimiia 1995) 2 3 4 58
  4. Development of genotyping methods for single nucleotide polymorphism in the human pancreatic ribonuclease gene (RNASE1) and their application to population studies. (PMID: 18219569) Ueki M … Yasuda T (Biochemical genetics 2008) 3 22 58
  5. The solution structure and dynamics of human pancreatic ribonuclease determined by NMR spectroscopy provide insight into its remarkable biological activities and inhibition. (PMID: 18495155) Kövér KE … Rico M (Journal of molecular biology 2008) 3 22 58

Products for RNASE1 Gene

Sources for RNASE1 Gene

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