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Aliases for RN7SL1 Gene

Subcategory (RNA class) for RN7SL1 Gene

SRP

Quality Score for this RNA gene is

13

Aliases for RN7SL1 Gene

  • RNA, 7SL, Cytoplasmic 1 2 3 5
  • RNA, 7SL, Cytoplasmic 2
  • RNSRP1 3
  • RN7SL 3
  • 7L1a 3
  • 7SL 3

External Ids for RN7SL1 Gene

ORGUL Members for RN7SL1 Gene

Previous HGNC Symbols for RN7SL1 Gene

  • RN7SL

Previous GeneCards Identifiers for RN7SL1 Gene

  • GC00U911064
  • GC14U900430
  • GC14P049126
  • GC14P050053
  • GC14P049588
  • GC14P049590
  • GC14P049595

Summaries for RN7SL1 Gene

Entrez Gene Summary for RN7SL1 Gene

  • The signal recognition particle (SRP) is a cytoplasmic ribonucleoprotein complex that mediates cotranslational insertion of secretory proteins into the lumen of the endoplasmic reticulum. The SRP consists of 6 polypeptides (e.g., SRP19; MIM 182175) and a 7SL RNA molecule, such as RN7SL1, that is partially homologous to Alu DNA (Ullu and Weiner, 1984 [PubMed 6084597]).[supplied by OMIM, Jul 2008]

GeneCards Summary for RN7SL1 Gene

RN7SL1 (RNA, 7SL, Cytoplasmic 1) is an RNA Gene, and is affiliated with the SRP RNA class. Diseases associated with RN7SL1 include Leishmaniasis and Dermatomyositis.

Gene Wiki entry for RN7SL1 Gene

Additional gene information for RN7SL1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RN7SL1 Gene

Genomics for RN7SL1 Gene

GeneHancer (GH) Regulatory Elements for RN7SL1 Gene

Promoters and enhancers for RN7SL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J049583 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 -0.8 -773 4 HDGF CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 RPS29 GC14M049586 GC14M049587 GC14P049611 PIR42644 ENSG00000283029 RN7SL1 LRR1 RPL36AL KLHDC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RN7SL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RN7SL1 gene promoter:
  • FOXO4
  • POU2F1a
  • POU2F1
  • Bach1
  • ER-alpha
  • AP-1
  • c-Fos
  • c-Jun
  • Nkx2-5

Genomic Locations for RN7SL1 Gene

Genomic Locations for RN7SL1 Gene
chr14:49,586,580-49,586,878
(GRCh38/hg38)
Size:
299 bases
Orientation:
Plus strand
chr14:50,053,297-50,053,596
(GRCh37/hg19)
Size:
300 bases
Orientation:
Plus strand

Genomic View for RN7SL1 Gene

Genes around RN7SL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RN7SL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RN7SL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RN7SL1 Gene

Proteins for RN7SL1 Gene

Post-translational modifications for RN7SL1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RN7SL1 Gene

Domains & Families for RN7SL1 Gene

Gene Families for RN7SL1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RN7SL1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RN7SL1 Gene

Function for RN7SL1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RN7SL1 Gene

Localization for RN7SL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RN7SL1 gene
Compartment Confidence
nucleus 2
endoplasmic reticulum 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RN7SL1 Gene

Pathways & Interactions for RN7SL1 Gene

SuperPathways for RN7SL1 Gene

No Data Available

Interacting Proteins for RN7SL1 Gene

Gene Ontology (GO) - Biological Process for RN7SL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RN7SL1 Gene

Drugs & Compounds for RN7SL1 Gene

No Compound Related Data Available

Transcripts for RN7SL1 Gene

mRNA/cDNA for RN7SL1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(1) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for RN7SL1 Gene

No ASD Table

Relevant External Links for RN7SL1 Gene

GeneLoc Exon Structure for
RN7SL1
ECgene alternative splicing isoforms for
RN7SL1

Expression for RN7SL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RN7SL1 Gene

mRNA differential expression in normal tissues according to GTEx for RN7SL1 Gene

This gene is overexpressed in Whole Blood (x7.2).

NURSA nuclear receptor signaling pathways regulating expression of RN7SL1 Gene:

RN7SL1
genes like me logo Genes that share expression patterns with RN7SL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RN7SL1 Gene

Orthologs for RN7SL1 Gene

Evolution for RN7SL1 Gene

ENSEMBL:
Gene Tree for RN7SL1 (if available)
TreeFam:
Gene Tree for RN7SL1 (if available)

No data available for Orthologs for RN7SL1 Gene

Paralogs for RN7SL1 Gene

No data available for Paralogs for RN7SL1 Gene

Variants for RN7SL1 Gene

Sequence variations from dbSNP and Humsavar for RN7SL1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs587777568 pathogenic, Diamond-Blackfan anemia 13 49,586,021(+) T/A upstream_transcript_variant
rs587777569 pathogenic, Diamond-Blackfan anemia 13 49,585,963(+) A/G upstream_transcript_variant
rs1064795244 likely-pathogenic, not provided 49,586,039(+) A/G upstream_transcript_variant
rs1000019179 -- 49,585,426(+) T/C upstream_transcript_variant
rs1000047799 -- 49,586,174(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RN7SL1 Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV gain+loss 19812545
nsv977464 CNV duplication 23825009

Additional Variant Information for RN7SL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RN7SL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RN7SL1 Gene

Disorders for RN7SL1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for RN7SL1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
leishmaniasis
  • cutaneous leishmaniasis
dermatomyositis
  • amyopathic dermatomyositis
polymyositis
  • pm
acquired immunodeficiency syndrome
  • aids
diamond-blackfan anemia 13
  • dba13
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RN7SL1

genes like me logo Genes that share disorders with RN7SL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RN7SL1 Gene

Publications for RN7SL1 Gene

  1. Novel upstream and intragenic control elements for the RNA polymerase III-dependent transcription of human 7SL RNA genes. (PMID: 15667936) Englert M … Beier H (Biochimie 2004) 2 3 58
  2. Induced structural changes of 7SL RNA during the assembly of human signal recognition particle. (PMID: 12244299) Kuglstatter A … Nagai K (Nature structural biology 2002) 3 22 58
  3. Human genes and pseudogenes for the 7SL RNA component of signal recognition particle. (PMID: 6084597) Ullu E … Weiner AM (The EMBO journal 1984) 2 3 58
  4. Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer. (PMID: 28709002) Nabet BY … Minn AJ (Cell 2017) 3 58
  5. Tumor FOXP3 represses the expression of long noncoding RNA 7SL. (PMID: 26718402) Yang Y … Shan C (Biochemical and biophysical research communications 2016) 3 58

Products for RN7SL1 Gene

Sources for RN7SL1 Gene

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