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Aliases for RN7SKP90 Gene

Subcategory (RNA class) for RN7SKP90 Gene

7SK RNA

Aliases for RN7SKP90 Gene

  • RN7SK Pseudogene 90 2 3
  • RNA, 7SK Small Nuclear Pseudogene 90 2 3 5

External Ids for RN7SKP90 Gene

Summaries for RN7SKP90 Gene

GeneCards Summary for RN7SKP90 Gene

RN7SKP90 (RN7SK Pseudogene 90) is a Pseudogene, and is affiliated with the 7SK RNA class.

fRNAdb sequence ontologies for RN7SKP90 Gene - the ORGUL cluster for this gene includes several descriptions:

  • snRNA: A small nuclear RNA molecule involved in pre-mRNA splicing and processing.

  • 7SK RNA: 7SK was discovered as an abundant small nuclear RNA in the mid-70s but a possible function has only recently been suggested [1]. Two independent studies have found that 7SK RNA binds the CDK9/cyclin T complex (known as elongation factor P-TEFb). P-TEFb activates transcription by phosphorylating the C-terminal domain of RNA polymerase II. This process is negatively regulated by the 7SK RNP. The secondary structure of 7SK RNA shown here was proposed by Wasserman and Steitz on the basis of chemical modification and enzymatic cleavage experiments [2]. This family contains a number of annotated pseudogenes and 7SK derived repeats. The threshold is artificially high to minimise the pseudogene count.

View fRNAdb secondary structures for RN7SKP90

Additional gene information for RN7SKP90 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RN7SKP90 Gene

Genomics for RN7SKP90 Gene

GeneHancer (GH) Regulatory Elements for RN7SKP90 Gene

Promoters and enhancers for RN7SKP90 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J016875 Promoter/Enhancer 1.8 VISTA Ensembl ENCODE dbSUPER 0.3 +36.9 36939 9.6 CTCF MAFK SP7 IKZF1 ZIC2 REST ZNF740 PKNOX1 ZNF24 ZNF316 RPS13 SNORD14B OR7E14P PLEKHA7 RN7SKP90 ENSG00000244398
GH11J016845 Enhancer 0.7 Ensembl ENCODE 0.7 +4.2 4224 1.4 SP1 PRDM1 RXRA HNF4A RN7SKP90 ENSG00000244398 PLEKHA7
GH11J016854 Enhancer 1.1 Ensembl ENCODE 0.4 +13.2 13247 4.6 CC2D1A CBFA2T2 NCOA6 TRIM24 EGR1 SMARCA4 GMEB1 DPF2 IKZF1 ZIC2 ENSG00000244398 PLEKHA7 RN7SKP90
GH11J016891 Enhancer 1.3 VISTA Ensembl ENCODE dbSUPER 0.2 +51.5 51493 4.9 POLR2A CTBP1 FOXA2 ZNF217 DPF2 GATA3 SMARCE1 OR7E14P PLEKHA7 ENSG00000244398 RPS13 SNORD14B RN7SKP90 GC11M016889
GH11J016820 Enhancer 0.9 Ensembl ENCODE 0.3 -21.5 -21479 1.3 CTCF RAD21 ZNF600 ZNF143 REST SP1 TRIM22 IRF2 OSR2 ZBTB17 ENSG00000244398 GC11P016807 RN7SKP90 PLEKHA7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RN7SKP90 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RN7SKP90 Gene

Genomic Locations for RN7SKP90 Gene
chr11:16,842,253-16,842,587
(GRCh38/hg38)
Size:
335 bases
Orientation:
Plus strand
chr11:16,863,800-16,864,134
(GRCh37/hg19)
Size:
335 bases
Orientation:
Plus strand

Genomic View for RN7SKP90 Gene

Genes around RN7SKP90 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RN7SKP90 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RN7SKP90 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RN7SKP90 Gene

ORGUL Member Location for RN7SKP90 Gene

ORGUL Member Location for RN7SKP90 gene

Proteins for RN7SKP90 Gene

Post-translational modifications for RN7SKP90 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RN7SKP90 Gene

Domains & Families for RN7SKP90 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RN7SKP90 Gene

Function for RN7SKP90 Gene

Phenotypes From GWAS Catalog for RN7SKP90 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RN7SKP90 Gene

Localization for RN7SKP90 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RN7SKP90 Gene

Pathways & Interactions for RN7SKP90 Gene

PathCards logo

SuperPathways for RN7SKP90 Gene

No Data Available

Interacting Proteins for RN7SKP90 Gene

Gene Ontology (GO) - Biological Process for RN7SKP90 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RN7SKP90 Gene

Drugs & Compounds for RN7SKP90 Gene

No Compound Related Data Available

Transcripts for RN7SKP90 Gene

fRNAdb Secondary structures for RN7SKP90 Gene

  • RF00100;7SK;AADB02013703.1/223397-223063

mRNA/cDNA for RN7SKP90 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RN7SKP90 Gene

No ASD Table

Relevant External Links for RN7SKP90 Gene

GeneLoc Exon Structure for
RN7SKP90
ECgene alternative splicing isoforms for
RN7SKP90

Expression for RN7SKP90 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RN7SKP90 Gene

NURSA nuclear receptor signaling pathways regulating expression of RN7SKP90 Gene:

RN7SKP90
genes like me logo Genes that share expression patterns with RN7SKP90: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RN7SKP90 Gene

Orthologs for RN7SKP90 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RN7SKP90 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia 7SK 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia 7SK 35
  • 66 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia 7SK 35
  • 70 (a)
ManyToMany
Species where no ortholog for RN7SKP90 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RN7SKP90 Gene

ENSEMBL:
Gene Tree for RN7SKP90 (if available)
TreeFam:
Gene Tree for RN7SKP90 (if available)

Paralogs for RN7SKP90 Gene

No data available for Paralogs for RN7SKP90 Gene

Variants for RN7SKP90 Gene

Additional Variant Information for RN7SKP90 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RN7SKP90

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for RN7SKP90 Gene

Disorders for RN7SKP90 Gene

No disorders were found for RN7SKP90 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for RN7SKP90 Gene

Publications for RN7SKP90 Gene

  1. Transcription: surprising role for an elusive small nuclear RNA. (PMID: 11864590) Blencowe BJ (Current biology : CB 2002) 1
  2. Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function. (PMID: 1646389) Wassarman DA … Steitz JA (Molecular and cellular biology 1991) 1

No data available for External Links for RN7SKP90 Gene

Products for RN7SKP90 Gene

Sources for RN7SKP90 Gene

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