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Aliases for RN7SKP50 Gene

Subcategory (RNA class) for RN7SKP50 Gene


Aliases for RN7SKP50 Gene

  • RNA, 7SK Small Nuclear Pseudogene 50 2 3 5

External Ids for RN7SKP50 Gene

Summaries for RN7SKP50 Gene

GeneCards Summary for RN7SKP50 Gene

RN7SKP50 (RNA, 7SK Small Nuclear Pseudogene 50) is a Pseudogene, and is affiliated with the 7SK RNA class.

fRNAdb sequence ontologies for RN7SKP50 Gene - the ORGUL cluster for this gene includes several descriptions:

  • snRNA: A small nuclear RNA molecule involved in pre-mRNA splicing and processing.

  • 7SK RNA: 7SK was discovered as an abundant small nuclear RNA in the mid-70s but a possible function has only recently been suggested [1]. Two independent studies have found that 7SK RNA binds the CDK9/cyclin T complex (known as elongation factor P-TEFb). P-TEFb activates transcription by phosphorylating the C-terminal domain of RNA polymerase II. This process is negatively regulated by the 7SK RNP. The secondary structure of 7SK RNA shown here was proposed by Wasserman and Steitz on the basis of chemical modification and enzymatic cleavage experiments [2]. This family contains a number of annotated pseudogenes and 7SK derived repeats. The threshold is artificially high to minimise the pseudogene count.

View fRNAdb secondary structures for RN7SKP50

Additional gene information for RN7SKP50 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RN7SKP50 Gene

Genomics for RN7SKP50 Gene

GeneHancer (GH) Regulatory Elements for RN7SKP50 Gene

Promoters and enhancers for RN7SKP50 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J009681 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 650.7 +1.2 1228 1.1 SAP130 SP5 IKZF1 ARID4B IKZF2 RUNX3 RAD21 FOXP1 RN7SKP50 RPL21P97 SWAP70 WEE1 GC11P009745 GC11P009430
GH11J009686 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +9.6 9566 8 HDGF PKNOX1 BATF ATF7 RCOR1 ETV6 BCLAF1 IKZF2 RUNX3 CBFB SWAP70 RPL21P97 ENSG00000238387 WEE1 SBF2-AS1 LOC105376544 RN7SKP50 GC11P009745 GC11P009430
GH11J009715 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.3 +37.8 37840 6.1 HDGF PKNOX1 ATF1 IRF4 ZNF766 ZNF143 ATF7 RUNX3 JUNB ATF4 RPL21P97 SWAP70 TMEM9B-AS1 ZNF143 SBF2-AS1 GC11P009745 RN7SKP50
GH11J009674 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.4 -5.2 -5189 1.5 NANOG POLR2A CEBPB POU5F1 SIN3A ZZZ3 ENSG00000254397 TMEM9B-AS1 ST5 ENSG00000238387 WEE1 SWAP70 NRIP3 RN7SKP50 GC11P009430
GH11J009701 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.3 +22.0 22044 2.2 PKNOX1 NFIB FEZF1 ZNF121 ATF7 BCLAF1 RUNX3 EGR2 OVOL3 ZNF843 SBF2-AS1 RN7SKP50 SWAP70 GC11P009745 GC11P009430
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RN7SKP50 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RN7SKP50 Gene

Genomic Locations for RN7SKP50 Gene
315 bases
Plus strand
315 bases
Plus strand

Genomic View for RN7SKP50 Gene

Genes around RN7SKP50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RN7SKP50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RN7SKP50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RN7SKP50 Gene

ORGUL Member Location for RN7SKP50 Gene

ORGUL Member Location for RN7SKP50 gene

Function for RN7SKP50 Gene

Phenotypes From GWAS Catalog for RN7SKP50 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RN7SKP50 Gene

Localization for RN7SKP50 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RN7SKP50 Gene

Pathways & Interactions for RN7SKP50 Gene

SuperPathways for RN7SKP50 Gene

No Data Available

Interacting Proteins for RN7SKP50 Gene

Gene Ontology (GO) - Biological Process for RN7SKP50 Gene


No data available for Pathways by source and SIGNOR curated interactions for RN7SKP50 Gene

Drugs & Compounds for RN7SKP50 Gene

No Compound Related Data Available

Transcripts for RN7SKP50 Gene

fRNAdb Secondary structures for RN7SKP50 Gene

  • RF00100;7SK;ABSL01074274.1/28036-27722

mRNA/cDNA for RN7SKP50 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RN7SKP50 Gene

No ASD Table

Relevant External Links for RN7SKP50 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RN7SKP50 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RN7SKP50 Gene

NURSA nuclear receptor signaling pathways regulating expression of RN7SKP50 Gene:

genes like me logo Genes that share expression patterns with RN7SKP50: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RN7SKP50 Gene

Orthologs for RN7SKP50 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RN7SKP50 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia 7SK 34
  • 92 (a)
(Canis familiaris)
Mammalia 7SK 34
  • 65 (a)
(Bos Taurus)
Mammalia 7SK 34
  • 62 (a)
(Monodelphis domestica)
Mammalia 7SK 34
  • 58 (a)
Species where no ortholog for RN7SKP50 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RN7SKP50 Gene

Gene Tree for RN7SKP50 (if available)
Gene Tree for RN7SKP50 (if available)

Paralogs for RN7SKP50 Gene

No data available for Paralogs for RN7SKP50 Gene

Variants for RN7SKP50 Gene

Additional Variant Information for RN7SKP50 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for RN7SKP50 Gene

Disorders for RN7SKP50 Gene

No disorders were found for RN7SKP50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for RN7SKP50 Gene

Publications for RN7SKP50 Gene

  1. Transcription: surprising role for an elusive small nuclear RNA. (PMID: 11864590) Blencowe BJ (Current biology : CB 2002) 1
  2. Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function. (PMID: 1646389) Wassarman DA … Steitz JA (Molecular and cellular biology 1991) 1

Products for RN7SKP50 Gene

Sources for RN7SKP50 Gene

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