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Aliases for RN7SKP21 Gene

Subcategory (RNA class) for RN7SKP21 Gene

7SK RNA

Aliases for RN7SKP21 Gene

  • RNA, 7SK Small Nuclear Pseudogene 21 2 3 5

External Ids for RN7SKP21 Gene

ORGUL Members for RN7SKP21 Gene

Previous GeneCards Identifiers for RN7SKP21 Gene

  • GC14M036702

Summaries for RN7SKP21 Gene

GeneCards Summary for RN7SKP21 Gene

RN7SKP21 (RNA, 7SK Small Nuclear Pseudogene 21) is a Pseudogene, and is affiliated with the 7SK RNA class.

fRNAdb sequence ontologies for RN7SKP21 Gene

  • 7SK RNA: 7SK was discovered as an abundant small nuclear RNA in the mid-70s but a possible function has only recently been suggested [1]. Two independent studies have found that 7SK RNA binds the CDK9/cyclin T complex (known as elongation factor P-TEFb). P-TEFb activates transcription by phosphorylating the C-terminal domain of RNA polymerase II. This process is negatively regulated by the 7SK RNP. The secondary structure of 7SK RNA shown here was proposed by Wasserman and Steitz on the basis of chemical modification and enzymatic cleavage experiments [2]. This family contains a number of annotated pseudogenes and 7SK derived repeats. The threshold is artificially high to minimise the pseudogene count.

Additional gene information for RN7SKP21 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RN7SKP21 Gene

Genomics for RN7SKP21 Gene

GeneHancer (GH) Regulatory Elements for RN7SKP21 Gene

Promoters and enhancers for RN7SKP21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J036318 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 0.2 -88.2 -88164 2.7 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B MBIP ENSG00000283098 LOC644584 RALGAPA1 RN7SKP21
GH14J036272 Enhancer 1.1 UCNEbase Ensembl 0.3 -40.7 -40689 0.5 PKNOX1 ZSCAN4 MZF1 ZNF384 FEZF1 ZIC2 ZNF2 ZNF324 ZNF335 CTBP1 MBIP RPL29P3 NKX2-8 RN7SKP21
GH14J036238 Enhancer 0.7 Ensembl ENCODE 0.4 -7.0 -7008 1 FOSL1 ZFHX2 EGR1 ATF7 FOS ATF2 EGR2 RN7SKP21 MBIP
GH14J036269 Enhancer 0.9 UCNEbase ENCODE 0.3 -37.8 -37773 0.9 OSR2 NANOG L3MBTL2 ZSCAN4 POU5F1 ZIC2 MBIP RPL29P3 NKX2-8 RN7SKP21
GH14J036317 Enhancer 0.7 ENCODE 0.2 -86.1 -86056 0.2 PKNOX1 JUN GATA3 ZNF366 FOSL2 FOS TCF7L2 ZNF639 ZEB2 ATF2 MBIP RN7SKP21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RN7SKP21 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RN7SKP21 Gene

Genomic Locations for RN7SKP21 Gene
chr14:36,231,555-36,231,774
(GRCh38/hg38)
Size:
220 bases
Orientation:
Minus strand
chr14:36,700,761-36,700,980
(GRCh37/hg19)

Genomic View for RN7SKP21 Gene

Genes around RN7SKP21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RN7SKP21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RN7SKP21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RN7SKP21 Gene

Function for RN7SKP21 Gene

Phenotypes From GWAS Catalog for RN7SKP21 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RN7SKP21 Gene

Localization for RN7SKP21 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RN7SKP21 Gene

Pathways & Interactions for RN7SKP21 Gene

SuperPathways for RN7SKP21 Gene

No Data Available

Interacting Proteins for RN7SKP21 Gene

Gene Ontology (GO) - Biological Process for RN7SKP21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RN7SKP21 Gene

Drugs & Compounds for RN7SKP21 Gene

No Compound Related Data Available

Transcripts for RN7SKP21 Gene

mRNA/cDNA for RN7SKP21 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RN7SKP21 Gene

No ASD Table

Relevant External Links for RN7SKP21 Gene

GeneLoc Exon Structure for
RN7SKP21
ECgene alternative splicing isoforms for
RN7SKP21

Expression for RN7SKP21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RN7SKP21 Gene

mRNA differential expression in normal tissues according to GTEx for RN7SKP21 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x14.6), Brain - Substantia nigra (x7.9), Brain - Hippocampus (x6.9), Brain - Caudate (basal ganglia) (x4.5), and Brain - Hypothalamus (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of RN7SKP21 Gene:

RN7SKP21
genes like me logo Genes that share expression patterns with RN7SKP21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RN7SKP21 Gene

Orthologs for RN7SKP21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RN7SKP21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia 7SK 34
  • 48 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia 7SK 34
  • 47 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm22533 34
  • 39 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia 7SK 34
  • 24 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia 7SK 34
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea 7SK 34 34 34
  • 28 (a)
ManyToMany
Species where no ortholog for RN7SKP21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RN7SKP21 Gene

ENSEMBL:
Gene Tree for RN7SKP21 (if available)
TreeFam:
Gene Tree for RN7SKP21 (if available)

Paralogs for RN7SKP21 Gene

No data available for Paralogs for RN7SKP21 Gene

Variants for RN7SKP21 Gene

Additional Variant Information for RN7SKP21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RN7SKP21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for RN7SKP21 Gene

Disorders for RN7SKP21 Gene

No disorders were found for RN7SKP21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for RN7SKP21 Gene

Publications for RN7SKP21 Gene

No publications were found for RN7SKP21 Gene.

Products for RN7SKP21 Gene

Sources for RN7SKP21 Gene

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