Aliases for RN7SK Gene
Subcategory (RNA class) for RN7SK Gene
7SK RNA
Quality Score for this RNA gene is
13
Aliases for RN7SK Gene
External Ids for RN7SK Gene
- HGNC: 10037
- Entrez Gene: 125050
- Ensembl: ENSG00000283293
- OMIM: 606515
ORGUL Members for RN7SK Gene
Previous GeneCards Identifiers for RN7SK Gene
- GC06U990106
- GC06P052907
- GC06P052968
- GC06P052860
- GC06P052691
Summaries for RN7SK Gene
GeneCards Summary for RN7SK Gene
RN7SK (RNA, 7SK Small Nuclear) is an RNA Gene, and is affiliated with the 7SK RNA class. Diseases associated with RN7SK include Acquired Immunodeficiency Syndrome and Gastric Cancer.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RN7SK Gene
Genomics for RN7SK Gene
GeneHancer (GH) Regulatory Elements for RN7SK Gene
Promoters and enhancers for RN7SK Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J052992 | Promoter/Enhancer | 2.3 | EPDnew Ensembl ENCODE dbSUPER | 650.7 | -0.6 | -579 | 4.1 | ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC | RN7SK GSTA4 GC06P052997 ENSG00000202198 MCM3 EFHC1 ICK TRAM2 GSTA3 GC06P052982 | |
| GH06J053009 | Enhancer | 0.9 | ENCODE dbSUPER | 0.4 | +17.6 | 17564 | 7.1 | HDAC1 PKNOX1 NFIB NEUROD1 SIN3A FOSL1 CTBP1 GATA3 ATF7 RCOR1 | ICK FBXO9 GC06P053016 RN7SK ENSG00000202198 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around RN7SK on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RN7SK gene promoter:
-
- HEN1
- oct-B3
- Oct-B1
- oct-B2
- POU2F1
- POU2F1a
- POU2F2
- POU2F2 (Oct-2.1)
- POU2F2B
- POU2F2C
Regulatory Element Products
Genomic Locations for RN7SK Gene
Genomic Locations for RN7SK Gene
- chr6:52,995,620-52,995,951
- (GRCh38/hg38)
- Size:
- 332 bases
- Orientation:
- Plus strand
- chr6:52,860,418-52,860,749
- (GRCh37/hg19)
- Size:
- 332 bases
- Orientation:
- Plus strand
Genomic View for RN7SK Gene
Genes around RN7SK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p12.2 by Entrez Gene
- 6p12.2 by HGNC
- 6p12.2 by Ensembl
RN7SK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RN7SK Gene
Proteins for RN7SK Gene
Post-translational modifications for RN7SK Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for RN7SK
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RN7SK
- Origene Custom Protein Services for RN7SK
- Search GeneTex for Proteins for RN7SK
No data available for DME Specific Peptides for RN7SK Gene
Domains & Families for RN7SK Gene
Gene Families for RN7SK Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RN7SK Gene
Function for RN7SK Gene
Molecular function for RN7SK Gene
- GENATLAS Biochemistry:
- small nuclear RNA,7SK
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RN7SK
-
CRISPR Products
- Browse CRISPR knockouts for RN7SK
- Applied Biological Materials CRISPR for RN7SK
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA for RN7SK Gene
- miRTarBase miRNAs that target RN7SK
miRNA Products
Inhibitory RNA Products
Clone Products
- GenScript: Custom all cDNA clones Services for RN7SK
- Addgene plasmids for RN7SK
- Applied Biological Materials Clones for RN7SK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RN7SK Gene
Localization for RN7SK Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RN7SK Gene
Transcripts for RN7SK Gene
mRNA/cDNA for RN7SK Gene
- (71) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000636484 328 bps
- (12) RNA Central transcripts :
CRISPR Products
- Browse CRISPR knockouts for RN7SK
- Applied Biological Materials CRISPR for RN7SK
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
Inhibitory RNA Products
Clone Products
- GenScript: Custom all cDNA clones Services for RN7SK
- Addgene plasmids for RN7SK
- Applied Biological Materials Clones for RN7SK
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for RN7SK Gene
mRNA differential expression in normal tissues according to GTEx for RN7SK Gene
This gene is overexpressed in Kidney - Cortex (x5.1).
NURSA nuclear receptor signaling pathways regulating expression of RN7SK Gene:
RN7SKPrimer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RN7SK Gene
Orthologs for RN7SK Gene
No data available for Orthologs for RN7SK Gene
Paralogs for RN7SK Gene
No data available for Paralogs for RN7SK Gene
Variants for RN7SK Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000210850 | -- | 52,994,666(+) | A/C | upstream_transcript_variant | |
| rs1000360756 | -- | 52,995,937(+) | G/A | non_coding_transcript_variant | |
| rs1000885244 | -- | 52,996,159(+) | T/G | downstream_transcript_variant | |
| rs1001172400 | -- | 52,993,837(+) | C/T | upstream_transcript_variant | |
| rs1002126456 | -- | 52,994,698(+) | T/A | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759430 | CNV | loss | 17122850 |
Additional Variant Information for RN7SK Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RN7SK
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RN7SK Gene
Disorders for RN7SK Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acquired immunodeficiency syndrome |
|
|
| gastric cancer |
|
Search RN7SK in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RN7SK
No data available for UniProtKB/Swiss-Prot and Genatlas for RN7SK Gene
Publications for RN7SK Gene
- 7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor. (PMID: 19246988) Diribarne G … Bensaude O (RNA biology 2009) 2 3 58
- Regulation of two key nuclear enzymatic activities by the 7SK small nuclear RNA. (PMID: 17381310) He WJ … Zhou Q (Cold Spring Harbor symposia on quantitative biology 2006) 3 22 58
- Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. (PMID: 16109377) Yang Z … Zhou Q (Molecular cell 2005) 3 22 58
- Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA. (PMID: 14627702) Chen R … Zhou Q (The Journal of biological chemistry 2004) 3 22 58
- A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb. (PMID: 15169877) Yik JH … Zhou Q (Molecular and cellular biology 2004) 3 22 58
Products for RN7SK Gene
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Sources for RN7SK Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
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- (125) NCBI Bookshelf
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- (133) ENCODE
- (134) ProSci
- (135) Horizon
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- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt