This gene produces a long non-coding RNA that functions in neurogenesis by aiding in the association of Sox2 transcription factor to its target promoters. [provided by RefSeq, Dec 2017] See more...
Aliases for RMST Gene
Subcategory (RNA class) for RMST Gene
misc_RNA
Quality Score for this RNA gene is
15
Aliases for RMST Gene
External Ids for RMST Gene
- HGNC: 29893
- Entrez Gene: 196475
- Ensembl: ENSG00000255794
- OMIM: 607045
Previous GeneCards Identifiers for RMST Gene
- GC12P096362
- GC12U900573
- GC12P097858
Summaries for RMST Gene
-
This gene produces a long non-coding RNA that functions in neurogenesis by aiding in the association of Sox2 transcription factor to its target promoters. [provided by RefSeq, Dec 2017]
GeneCards Summary for RMST Gene
RMST (Rhabdomyosarcoma 2 Associated Transcript) is an RNA Gene, and is affiliated with the misc_RNA class. Diseases associated with RMST include Rhabdomyosarcoma and Melanoma.
Rfam classification for RMST Gene
-
Rhabdomyosarcoma 2 associated transcript conserved region 1
-
Rhabdomyosarcoma 2 associated transcript conserved region 6
-
Rhabdomyosarcoma 2 associated transcript conserved region 8
-
Rhabdomyosarcoma 2 associated transcript conserved region 2
-
Rhabdomyosarcoma 2 associated transcript conserved region 3
-
Rhabdomyosarcoma 2 associated transcript conserved region 4
-
Rhabdomyosarcoma 2 associated transcript conserved region 5
-
Rhabdomyosarcoma 2 associated transcript conserved region 9
-
Rhabdomyosarcoma 2 associated transcript conserved region 10
-
Rhabdomyosarcoma 2 associated transcript conserved region 7
-
mir-135 microRNA precursor family
Additional gene information for RMST Gene
- Monarch Initiative
- Search for RMST at DataMed
- Search for RMST at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary and piRNA Summary for RMST Gene
Genomics for RMST Gene
GeneHancer (GH) Regulatory Elements for RMST Gene
Promoters and enhancers for RMST Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12J097428 | Enhancer | 0.3 | Ensembl | 750.6 | -1.6 | -1632 | 1.2 | NFE2 | RMST piR-34974-005 | |
| GH12J097565 | Enhancer | 1.3 | Ensembl ENCODE dbSUPER | 15.2 | +139.2 | 139179 | 7.8 | GATA3 SREBF1 LCORL FOXA1 MLX RBPJ TCF7L2 NR2F1 NR2F6 ATF1 | RMST NEDD1 MIR1251 ENSG00000277081 piR-38562-020 | |
| GH12J097464 | Promoter/Enhancer | 1.2 | Ensembl ENCODE CraniofacialAtlas | 11.5 | +34.7 | 34668 | 5.4 | POU5F1 ZNF652 SP1 POLR2A SIN3A NANOG | MIR1251 RMST lnc-NEDD1-8 | |
| GH12J097554 | Enhancer | 1.6 | UCNEbase FANTOM5 Ensembl ENCODE dbSUPER | 4.9 | +129.4 | 129364 | 11.3 | GATA3 TCF7L2 ZNF217 POU5F1 ELF3 NCOA3 PPARG KAT8 ZNF644 CREB1 | ENSG00000276398 ENSG00000278802 ENSG00000257501 RMST ENSG00000277081 ENSG00000279798 MIR135A2 ENSG00000251844 | |
| GH12J097534 | Enhancer | 0.5 | Ensembl dbSUPER | 15.3 | +103.5 | 103468 | 2.2 | MAFK ZNF316 | ENSG00000274819 RMST MIR135A2 MIR1251 ENSG00000251844 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RMST on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RMST gene promoter:
-
- FOXO4
- GR
- GR-alpha
- HEN1
- ITF-2
- POU3F1
- POU6F1 (c2)
- STAT5B
- Tal-1beta
- TBP
Genomic Locations for RMST Gene
Genomic Locations for RMST Gene
- chr12:97,430,633-97,598,415
- (GRCh38/hg38)
- Size:
- 167,783 bases
- Orientation:
- Plus strand
- chr12:97,825,431-97,958,813
- (GRCh37/hg19)
- Size:
- 133,383 bases
- Orientation:
- Plus strand
Genomic View for RMST Gene
Genes around RMST on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q23.1 by HGNC
- 12q23.1|12q21 by Entrez Gene
- 12q23.1 by Ensembl
RMST Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RMST Gene
Proteins for RMST Gene
Post-translational modifications for RMST Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RMST
- Origene Custom Protein Services for RMST
No data available for DME Specific Peptides for RMST Gene
Domains & Families for RMST Gene
Gene Families for RMST Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RMST Gene
Function for RMST Gene
Phenotypes From GWAS Catalog for RMST Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RMST - Select products 50% OFF >
- * RMST CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * RMST CRISPR applications: KO, Activation, Repression, and more - Browse All
- Browse CRISPR knockouts for RMST
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for RMST - Select products 50% OFF >
- * RMST as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * RMST tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RMST Gene
Localization for RMST Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RMST Gene
Transcripts for RMST Gene
mRNA/cDNA for RMST Gene
- (2) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (28) Selected AceView cDNA sequences:
- (34) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000538559 2598 bps (ENST00000538559.6)
- ENST00000541282 2099 bps (ENST00000541282.5)
- ENST00000547946 687 bps (ENST00000547946.1)
- ENST00000547996 1621 bps (ENST00000547996.1)
- ENST00000548886 1125 bps (ENST00000548886.1)
- (16) NONCODE transcripts :
- (42) RNACentral transcripts :
- (21) LncBook transcripts :
- (36) LNCipedia transcripts :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RMST - Select products 50% OFF >
- * RMST CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * RMST CRISPR applications: KO, Activation, Repression, and more - Browse All
- Browse CRISPR knockouts for RMST
miRNA Products
Inhibitory RNA Products
Clone Products
- Applied Biological Materials (abm): Clones for RMST - Select products 50% OFF >
- * RMST as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * RMST tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for RMST Gene
mRNA differential expression in normal tissues according to GTEx for RMST Gene
This gene is overexpressed in Thyroid (x24.7) and Pituitary (x8.2).
NURSA nuclear receptor signaling pathways regulating expression of RMST Gene:
RMSTSOURCE GeneReport for Unigene cluster for RMST Gene:
Hs.652568Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RMST Gene
Orthologs for RMST Gene
No data available for Orthologs for RMST Gene
Paralogs for RMST Gene
No data available for Paralogs for RMST Gene
Variants for RMST Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000018153 | -- | 97,495,374(+) | A/G | intron_variant | |
| rs1000021364 | -- | 97,500,135(+) | C/A | intron_variant | |
| rs1000082289 | -- | 97,507,145(+) | A/G | intron_variant | |
| rs1000087482 | -- | 97,545,413(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000103282 | -- | 97,503,042(+) | A/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv499e212 | CNV | loss | 25503493 |
| esv2665672 | CNV | deletion | 23128226 |
| esv3630475 | CNV | loss | 21293372 |
| esv3630476 | CNV | loss | 21293372 |
| esv3630477 | CNV | loss | 21293372 |
| nsv1129163 | CNV | insertion | 24896259 |
| nsv438229 | CNV | loss | 16468122 |
| nsv7234 | OTHER | inversion | 18451855 |
| nsv832495 | CNV | gain | 17160897 |
| nsv840 | CNV | insertion | 18451855 |
Additional Variant Information for RMST Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RMST
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RMST Gene
Disorders for RMST Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rhabdomyosarcoma |
|
|
| melanoma |
|
|
| breast cancer |
|
|
| rhabdomyosarcoma 2 |
|
|
| coronary artery anomaly |
|
|
Search RMST in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RMST
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for RMST Gene
Publications for RMST Gene
- The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis. (PMID: 23932716) Ng SY … Stanton LW (Molecular cell 2013) 2 3 56
- Rmst is a novel marker for the mouse ventral mesencephalic floor plate and the anterior dorsal midline cells. (PMID: 20062813) Uhde CW … Li M (PloS one 2010) 2 3 56
- Identification of a novel gene NCRMS on chromosome 12q21 with differential expression between rhabdomyosarcoma subtypes. (PMID: 12082533) Chan AS … Zielenska M (Oncogene 2002) 2 3 56
- Long non-coding RNA (LncRNA) RMST in triple-negative breast cancer (TNBC): Expression analysis and biological roles research. (PMID: 29215701) Wang L … Liu Z (Journal of cellular physiology 2018) 3 56
- Long non-coding RNA RMST silencing protects against middle cerebral artery occlusion (MCAO)-induced ischemic stroke. (PMID: 29258823) Hou XX … Cheng H (Biochemical and biophysical research communications 2018) 3 56
ExternalLinks
Products for RMST Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RMST
- Origene Custom Protein Services for RMST
- Browse OriGene Inhibitory RNA Products For RMST
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for RMST
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RMST
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for RMST
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for RMST
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RMST
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for RMST
Sources for RMST Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource