Aliases for RMND5B Gene
External Ids for RMND5B Gene
Previous GeneCards Identifiers for RMND5B Gene
GeneCards Summary for RMND5B Gene
RMND5B (Required For Meiotic Nuclear Division 5 Homolog B) is a Protein Coding gene. Diseases associated with RMND5B include Dyskeratosis Congenita, Autosomal Recessive 2 and Dyskeratosis Congenita, Autosomal Recessive 1. An important paralog of this gene is RMND5A.
UniProtKB/Swiss-Prot Summary for RMND5B Gene
Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972).