Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RMND5B Gene

Aliases for RMND5B Gene

  • Required For Meiotic Nuclear Division 5 Homolog B 2 3 5
  • GID Complex Subunit 2 Homolog B 2 3
  • Required For Meiotic Nuclear Division 5 Homolog B (S. Cerevisiae) 2
  • Protein RMD5 Homolog B 3
  • GID2B 3
  • GID2 3

External Ids for RMND5B Gene

Previous GeneCards Identifiers for RMND5B Gene

  • GC05P177492
  • GC05P177557
  • GC05P172284

Summaries for RMND5B Gene

GeneCards Summary for RMND5B Gene

RMND5B (Required For Meiotic Nuclear Division 5 Homolog B) is a Protein Coding gene. An important paralog of this gene is RMND5A.

Gene Wiki entry for RMND5B Gene

Additional gene information for RMND5B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMND5B Gene

Genomics for RMND5B Gene

GeneHancer (GH) Regulatory Elements for RMND5B Gene

Promoters and enhancers for RMND5B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J178129 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 669.9 +0.2 205 2.8 HDGF PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B POLR2B ZNF213 E2F8 ZNF207 RMND5B ENSG00000247679 NSD1 FAM193B ZNF354B LOC202181 ZNF879 MXD3 HNRNPAB CLK4
GH05J178128 Enhancer 0.3 dbSUPER 650.7 -1.5 -1489 0.3 SREBF1 RMND5B N4BP3
GH05J178203 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.3 +79.2 79212 12.3 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 HNRNPAB ENSG00000247679 FAM193B ZNF879 LOC202181 ZNF354C CLK4 RMND5B ENSG00000254035 MXD3
GH05J177453 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 19.2 -673.7 -673667 6.9 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PRR7 PIR32965 NSD1 ZNF346 UIMC1 ZNF346-IT1 LOC202181 ENSG00000247679 RMND5B SLC34A1
GH05J178111 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 -10.4 -10415 16.8 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B IRF4 NSD1 ENSG00000247679 ZNF879 ZNF354B LOC202181 CLK4 N4BP3 FAM193B RMND5B HNRNPAB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RMND5B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RMND5B gene promoter:
  • FAC1
  • ZIC2
  • SREBP-1c
  • SREBP-1b
  • SREBP-1a
  • IRF-2
  • COUP
  • Max1
  • HEN1
  • Elk-1

Genomic Locations for RMND5B Gene

Genomic Locations for RMND5B Gene
20,034 bases
Plus strand
19,570 bases
Plus strand

Genomic View for RMND5B Gene

Genes around RMND5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMND5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMND5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMND5B Gene

Proteins for RMND5B Gene

  • Protein details for RMND5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein RMD5 homolog B
    Protein Accession:
    Secondary Accessions:
    • Q1HE27
    • Q6UVY7
    • Q9H6F6

    Protein attributes for RMND5B Gene

    393 amino acids
    Molecular mass:
    44414 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15303.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RMND5B Gene


neXtProt entry for RMND5B Gene

Post-translational modifications for RMND5B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RMND5B Gene

Domains & Families for RMND5B Gene

Gene Families for RMND5B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RMND5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RMND5B: view

No data available for UniProtKB/Swiss-Prot for RMND5B Gene

Function for RMND5B Gene

Phenotypes From GWAS Catalog for RMND5B Gene

Gene Ontology (GO) - Molecular Function for RMND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IBA --
GO:0005515 protein binding IEA,IPI 27173435
genes like me logo Genes that share ontologies with RMND5B: view
genes like me logo Genes that share phenotypes with RMND5B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RMND5B

miRNA for RMND5B Gene

miRTarBase miRNAs that target RMND5B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RMND5B Gene

Localization for RMND5B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RMND5B gene
Compartment Confidence
nucleus 4
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RMND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0034657 GID complex IBA --
genes like me logo Genes that share ontologies with RMND5B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RMND5B Gene

Pathways & Interactions for RMND5B Gene

SuperPathways for RMND5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMND5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with RMND5B: view

No data available for Pathways by source and SIGNOR curated interactions for RMND5B Gene

Drugs & Compounds for RMND5B Gene

No Compound Related Data Available

Transcripts for RMND5B Gene

Unigene Clusters for RMND5B Gene

Required for meiotic nuclear division 5 homolog B (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RMND5B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - -
SP4: - - - - - - -
SP5: - -
SP6: - - - - -
SP7: - - - - - -
SP8: - - - -
SP9: - - - -
SP10: -
SP12: -

ExUns: 14d

Relevant External Links for RMND5B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RMND5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RMND5B Gene

Protein differential expression in normal tissues from HIPED for RMND5B Gene

This gene is overexpressed in Testis (37.9) and Uterus (31.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RMND5B Gene

Protein tissue co-expression partners for RMND5B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RMND5B Gene:


SOURCE GeneReport for Unigene cluster for RMND5B Gene:


Evidence on tissue expression from TISSUES for RMND5B Gene

  • Lung(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RMND5B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RMND5B Gene

Orthologs for RMND5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RMND5B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RMND5B 34 33
  • 99.32 (n)
(Canis familiaris)
Mammalia RMND5B 34 33
  • 92.45 (n)
(Bos Taurus)
Mammalia RMND5B 34 33
  • 91.77 (n)
(Mus musculus)
Mammalia Rmnd5b 16 34 33
  • 89.06 (n)
(Rattus norvegicus)
Mammalia Rmnd5b 33
  • 88.89 (n)
(Ornithorhynchus anatinus)
Mammalia RMND5B 34
  • 82 (a)
(Anolis carolinensis)
Reptilia RMND5B 34
  • 85 (a)
(Danio rerio)
Actinopterygii rmnd5b 34 33
  • 69.48 (n)
zgc73277 33
fruit fly
(Drosophila melanogaster)
Insecta CG3295 34
  • 39 (a)
(Caenorhabditis elegans)
Secernentea T07D1.2 34 33
  • 40.81 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RMD5 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7116 34
  • 48 (a)
Species where no ortholog for RMND5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RMND5B Gene

Gene Tree for RMND5B (if available)
Gene Tree for RMND5B (if available)
Evolutionary constrained regions (ECRs) for RMND5B: view image

Paralogs for RMND5B Gene

Paralogs for RMND5B Gene

(2) SIMAP similar genes for RMND5B Gene using alignment to 7 proteins:

  • D6R9A2_HUMAN
  • F5H6G4_HUMAN
genes like me logo Genes that share paralogs with RMND5B: view

Variants for RMND5B Gene

Sequence variations from dbSNP and Humsavar for RMND5B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000026529 -- 178,138,604(+) T/C intron_variant
rs1000054862 -- 178,137,509(+) G/C intron_variant
rs1000097282 -- 178,144,980(+) T/G intron_variant
rs1000122032 -- 178,131,046(+) C/T 5_prime_UTR_variant
rs1000179599 -- 178,132,041(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RMND5B Gene

Variant ID Type Subtype PubMed ID
dgv5844n100 CNV gain 25217958
esv3352132 CNV duplication 20981092
esv3607706 CNV loss 21293372
nsv1019404 CNV gain 25217958
nsv1120062 OTHER inversion 24896259
nsv462567 CNV loss 19166990
nsv471058 CNV loss 18288195
nsv600392 CNV loss 21841781
nsv600394 CNV loss 21841781

Variation tolerance for RMND5B Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RMND5B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RMND5B Gene

Disorders for RMND5B Gene

Additional Disease Information for RMND5B

No disorders were found for RMND5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RMND5B Gene

Publications for RMND5B Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58

Products for RMND5B Gene

Sources for RMND5B Gene

Loading form....