Aliases for RMI2 Gene
External Ids for RMI2 Gene
Previous HGNC Symbols for RMI2 Gene
Previous GeneCards Identifiers for RMI2 Gene
RMI2 is a component of the BLM (RECQL3; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008 [PubMed 18923082]).[supplied by OMIM, Nov 2008]
GeneCards Summary for RMI2 Gene
RMI2 (RecQ Mediated Genome Instability 2) is a Protein Coding gene. Diseases associated with RMI2 include Microcephaly, Growth Restriction, And Increased Sister Chromatid Exchange 2 and Malignant Ovarian Cyst. Among its related pathways are Homologous DNA Pairing and Strand Exchange and Regulation of TP53 Activity.
UniProtKB/Swiss-Prot Summary for RMI2 Gene
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.