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Aliases for RMDN3 Gene

Aliases for RMDN3 Gene

  • Regulator Of Microtubule Dynamics 3 2 3 5
  • Protein Tyrosine Phosphatase-Interacting Protein 51 3 4
  • Family With Sequence Similarity 82, Member A2 2 3
  • TCPTP-Interacting Protein 51 3 4
  • Cerebral Protein 10 3 4
  • Ptpip51 3 4
  • FAM82A2 3 4
  • FAM82C 3 4
  • RMD-3 3 4
  • Family With Sequence Similarity 82, Member C 3
  • Regulator Of Microtubule Dynamics Protein 3 3
  • Microtubule-Associated Protein 3
  • Protein FAM82A2 4
  • Protein FAM82C 4
  • HRMD-3 4
  • RMD3 3

External Ids for RMDN3 Gene

Previous HGNC Symbols for RMDN3 Gene

  • FAM82C
  • FAM82A2

Previous GeneCards Identifiers for RMDN3 Gene

  • GC15M041029

Summaries for RMDN3 Gene

GeneCards Summary for RMDN3 Gene

RMDN3 (Regulator Of Microtubule Dynamics 3) is a Protein Coding gene. An important paralog of this gene is RMDN2.

UniProtKB/Swiss-Prot for RMDN3 Gene

  • Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.

Additional gene information for RMDN3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMDN3 Gene

Genomics for RMDN3 Gene

GeneHancer (GH) Regulatory Elements for RMDN3 Gene

Promoters and enhancers for RMDN3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I040753 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 568.8 +0.9 931 2.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 RMDN3 DNAJC17 CCDC32 INO80 BMF ENSG00000259211 RAD51 GC15P040718
GH15I040756 Enhancer 0.7 Ensembl 550.8 -1.1 -1050 0.2 KLF1 ZSCAN4 KLF17 SIN3A FEZF1 ZIC2 ZFHX2 GATA3 POLR2A PRDM10 RMDN3 CCDC32 SUMO2P15
GH15I040564 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 17.1 +190.7 190704 2.2 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B CCDC32 RMDN3 RPUSD2
GH15I040791 Enhancer 1.3 Ensembl ENCODE dbSUPER 25.1 -38.6 -38586 5.2 FOXA2 ARID4B FEZF1 BRCA1 YY1 FOS RXRA MIER2 REST PPARG ZFYVE19 RMDN3 CCDC32 C15orf62 SPINT1 GCHFR RAD51-AS1 RAD51 RHOV RPUSD2
GH15I040592 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.1 +161.5 161495 2.9 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D TRS-GCT4-2 KNL1 CCDC32 INO80 DNAJC17 ENSG00000259211 BMF RTF1 RMDN3 RAD51-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RMDN3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RMDN3 Gene

Genomic Locations for RMDN3 Gene
19,968 bases
Minus strand

Genomic View for RMDN3 Gene

Genes around RMDN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMDN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMDN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMDN3 Gene

Proteins for RMDN3 Gene

  • Protein details for RMDN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of microtubule dynamics protein 3
    Protein Accession:
    Secondary Accessions:
    • A9UMZ9
    • B3KRR3
    • Q6ZWE9
    • Q96H23
    • Q96SD6
    • Q9H6G1
    • Q9NVQ6

    Protein attributes for RMDN3 Gene

    470 amino acids
    Molecular mass:
    52118 Da
    Quaternary structure:
    • Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB.
    • Sequence=BAB15298.1; Type=Erroneous termination; Positions=453; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAC85554.1; Type=Frameshift; Positions=383; Evidence={ECO:0000305};

    Alternative splice isoforms for RMDN3 Gene


neXtProt entry for RMDN3 Gene

Post-translational modifications for RMDN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RMDN3 Gene

Domains & Families for RMDN3 Gene

Gene Families for RMDN3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RMDN3 Gene


Suggested Antigen Peptide Sequences for RMDN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The transmembrane region is required for mitochondrial localization.
  • Belongs to the RMDN family.
  • The transmembrane region is required for mitochondrial localization.
  • Belongs to the RMDN family.
genes like me logo Genes that share domains with RMDN3: view

Function for RMDN3 Gene

Molecular function for RMDN3 Gene

UniProtKB/Swiss-Prot Function:
Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.
UniProtKB/Swiss-Prot Induction:
By EGF, TGFB1, retinoic acid-and 1,25-dihydroxyvitamin D(3).

Gene Ontology (GO) - Molecular Function for RMDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18771726
genes like me logo Genes that share ontologies with RMDN3: view

Phenotypes for RMDN3 Gene

genes like me logo Genes that share phenotypes with RMDN3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RMDN3

CRISPR Products

miRNA for RMDN3 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RMDN3 Gene

Localization for RMDN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RMDN3 Gene

Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RMDN3 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
endoplasmic reticulum 2
plasma membrane 1
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RMDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane IEA,IDA 22131369
genes like me logo Genes that share ontologies with RMDN3: view

Pathways & Interactions for RMDN3 Gene

SuperPathways for RMDN3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMDN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis IMP 22131369
GO:0006915 apoptotic process IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with RMDN3: view

No data available for Pathways by source and SIGNOR curated interactions for RMDN3 Gene

Drugs & Compounds for RMDN3 Gene

No Compound Related Data Available

Transcripts for RMDN3 Gene

Unigene Clusters for RMDN3 Gene

Regulator of microtubule dynamics 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RMDN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP7: -
SP8: - - - -
SP9: - - - - - -
SP10: - -

ExUns: 15 ^ 16

Relevant External Links for RMDN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RMDN3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RMDN3 Gene

Protein differential expression in normal tissues from HIPED for RMDN3 Gene

This gene is overexpressed in Nasal epithelium (38.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RMDN3 Gene

Protein tissue co-expression partners for RMDN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RMDN3 Gene:


SOURCE GeneReport for Unigene cluster for RMDN3 Gene:


mRNA Expression by UniProt/SwissProt for RMDN3 Gene:

Tissue specificity: Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed.

Evidence on tissue expression from TISSUES for RMDN3 Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Lung(2.4)
  • Kidney(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with RMDN3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RMDN3 Gene

Orthologs for RMDN3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RMDN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM82A2 33 34
  • 99.86 (n)
(Canis familiaris)
Mammalia FAM82A2 33
  • 89.72 (n)
RMDN3 34
  • 89 (a)
(Bos Taurus)
Mammalia RMDN3 33 34
  • 87.79 (n)
(Rattus norvegicus)
Mammalia Rmdn3 33
  • 85.54 (n)
(Mus musculus)
Mammalia Rmdn3 33 16 34
  • 84.76 (n)
(Monodelphis domestica)
Mammalia RMDN3 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia RMDN3 34
  • 64 (a)
(Gallus gallus)
Aves FAM82A2 33
  • 66.3 (n)
RMDN3 34
  • 59 (a)
(Anolis carolinensis)
Reptilia RMDN3 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rmdn3 33
  • 59.55 (n)
(Danio rerio)
Actinopterygii rmdn3 33 34
  • 53.32 (n)
(Caenorhabditis elegans)
Secernentea rmd-4 34
  • 27 (a)
rmd-6 34
  • 27 (a)
rmd-3 34
  • 26 (a)
rmd-1 34
  • 23 (a)
rmd-2 34
  • 22 (a)
C16C8.18 34
  • 21 (a)
rmd-5 34
  • 21 (a)
sup-35 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for RMDN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RMDN3 Gene

Gene Tree for RMDN3 (if available)
Gene Tree for RMDN3 (if available)

Paralogs for RMDN3 Gene

Paralogs for RMDN3 Gene

(2) SIMAP similar genes for RMDN3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RMDN3: view

Variants for RMDN3 Gene

Sequence variations from dbSNP and Humsavar for RMDN3 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000116151 -- 40,755,005(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000117066 -- 40,747,654(-) G/A 5_prime_UTR_variant, intron_variant
rs1000138261 -- 40,737,505(-) G/A intron_variant
rs1000269920 -- 40,742,307(-) C/T intron_variant
rs1000743649 -- 40,749,195(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RMDN3 Gene

Variant ID Type Subtype PubMed ID
esv3305153 CNV mobile element insertion 20981092
esv3394772 CNV insertion 20981092
esv3450260 CNV insertion 20981092
nsv527234 CNV loss 19592680

Variation tolerance for RMDN3 Gene

Residual Variation Intolerance Score: 39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RMDN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RMDN3 Gene

Disorders for RMDN3 Gene

Additional Disease Information for RMDN3

No disorders were found for RMDN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RMDN3 Gene

Publications for RMDN3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis. (PMID: 22131369) De Vos KJ … Miller CC (Human molecular genetics 2012) 3 4 58
  3. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. (PMID: 18070910) Oishi K … Sawa H (The Journal of cell biology 2007) 3 4 58
  4. Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is a novel mitochondria protein with an N-terminal mitochondrial targeting sequence and induces apoptosis. (PMID: 16820967) Lv BF … Wang L (Apoptosis : an international journal on programmed cell death 2006) 3 4 58
  5. The novel protein PTPIP51 exhibits tissue- and cell-specific expression. (PMID: 15609043) Stenzinger A … Wimmer M (Histochemistry and cell biology 2005) 3 4 58

Products for RMDN3 Gene

Sources for RMDN3 Gene

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