Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RMDN2 Gene

Aliases for RMDN2 Gene

  • Regulator Of Microtubule Dynamics 2 2 3 5
  • Family With Sequence Similarity 82, Member A1 2 3
  • FAM82A1 3 4
  • FAM82A 3 4
  • RMD-2 3 4
  • Family With Sequence Similarity 82, Member A 3
  • Regulator Of Microtubule Dynamics Protein 2 3
  • Microtubule-Associated Protein 3
  • Protein FAM82A1 4
  • PRO34163 3
  • PYST9371 3
  • BLOCK18 3
  • HRMD-2 4
  • RMD2 3
  • RMD4 3

External Ids for RMDN2 Gene

Previous HGNC Symbols for RMDN2 Gene

  • FAM82A
  • FAM82A1

Previous GeneCards Identifiers for RMDN2 Gene

  • GC02P038151

Summaries for RMDN2 Gene

GeneCards Summary for RMDN2 Gene

RMDN2 (Regulator Of Microtubule Dynamics 2) is a Protein Coding gene. An important paralog of this gene is RMDN3.

Additional gene information for RMDN2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMDN2 Gene

Genomics for RMDN2 Gene

GeneHancer (GH) Regulatory Elements for RMDN2 Gene

Promoters and enhancers for RMDN2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I037921 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 565.8 +3.2 3246 5.5 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B RMDN2 DHX57 CYP1B1 GC02P037921 GC02P037956
GH02I037928 Promoter/Enhancer 1.3 EPDnew Ensembl 565.2 +7.7 7656 0.6 HDAC1 FOXA2 THAP11 MIXL1 EGR2 HMG20B SP5 CEBPB KAT8 NFIL3 RMDN2 GC02P037921 GC02P037956
GH02I037918 Enhancer 1 ENCODE 555.8 -1.0 -1010 2.9 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 SLC30A9 TCF12 RMDN2 GC02P037921 LINC00211
GH02I037950 Promoter 0.5 EPDnew 560.4 +29.6 29600 0.1 RMDN2 GC02P037956 GC02P037921 RMDN2-AS1
GH02I038070 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 7.8 +153.4 153378 7.6 PKNOX1 FOXA2 ARNT SIN3A YY1 GLIS2 E2F8 ZNF143 KLF7 FOS CYP1B1 CYP1B1-AS1 ENSG00000272054 SRSF7 DHX57 ASS1P2 CEBPZ HEATR5B RMDN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RMDN2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RMDN2 Gene

Genomic Locations for RMDN2 Gene
149,126 bases
Plus strand

Genomic View for RMDN2 Gene

Genes around RMDN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMDN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMDN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMDN2 Gene

Proteins for RMDN2 Gene

  • Protein details for RMDN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of microtubule dynamics protein 2
    Protein Accession:
    Secondary Accessions:
    • A9UMZ7
    • A9UN00
    • Q4ZG33
    • Q6UXN4
    • Q8N657
    • Q8N9A2
    • Q8NCV6
    • Q8NHM0

    Protein attributes for RMDN2 Gene

    410 amino acids
    Molecular mass:
    47399 Da
    Quaternary structure:
    • Interacts with microtubules.
    • Sequence=AAM81211.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RMDN2 Gene


neXtProt entry for RMDN2 Gene

Post-translational modifications for RMDN2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RMDN2 Gene

Domains & Families for RMDN2 Gene

Gene Families for RMDN2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RMDN2 Gene


Suggested Antigen Peptide Sequences for RMDN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RMDN family.
  • Belongs to the RMDN family.
genes like me logo Genes that share domains with RMDN2: view

Function for RMDN2 Gene

Phenotypes From GWAS Catalog for RMDN2 Gene

Gene Ontology (GO) - Molecular Function for RMDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RMDN2: view
genes like me logo Genes that share phenotypes with RMDN2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RMDN2 Gene

Localization for RMDN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RMDN2 Gene

Membrane; Single-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. Also detected as large dots in the perinuclear region.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RMDN2 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Mitotic spindle (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RMDN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005819 spindle IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RMDN2: view

Pathways & Interactions for RMDN2 Gene

SuperPathways for RMDN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMDN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for RMDN2 Gene

Drugs & Compounds for RMDN2 Gene

No Compound Related Data Available

Transcripts for RMDN2 Gene

Unigene Clusters for RMDN2 Gene

Regulator of microtubule dynamics 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RMDN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - - -

Relevant External Links for RMDN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RMDN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RMDN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RMDN2 Gene

This gene is overexpressed in Adrenal Gland (x6.6).

Protein differential expression in normal tissues from HIPED for RMDN2 Gene

This gene is overexpressed in Bone (19.4), Adrenal (15.0), and Liver (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RMDN2 Gene

Protein tissue co-expression partners for RMDN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of RMDN2 Gene:


SOURCE GeneReport for Unigene cluster for RMDN2 Gene:


Evidence on tissue expression from TISSUES for RMDN2 Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RMDN2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RMDN2 Gene

Orthologs for RMDN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RMDN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM82A1 33
  • 99.43 (n)
RMDN2 34
  • 90 (a)
(Canis familiaris)
Mammalia FAM82A1 33
  • 89.19 (n)
RMDN2 34
  • 54 (a)
(Rattus norvegicus)
Mammalia Rmdn2 33
  • 81.63 (n)
(Mus musculus)
Mammalia Rmdn2 33 16 34
  • 81.46 (n)
(Bos Taurus)
Mammalia RMDN2 34
  • 47 (a)
(Monodelphis domestica)
Mammalia RMDN2 34
  • 39 (a)
(Ornithorhynchus anatinus)
Mammalia RMDN2 34
  • 37 (a)
(Gallus gallus)
Aves FAM82A1 33
  • 64.79 (n)
RMDN2 34
  • 35 (a)
(Anolis carolinensis)
Reptilia RMDN2 34
  • 34 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rmdn2 33
  • 60.95 (n)
(Danio rerio)
Actinopterygii RMDN2 34
  • 27 (a)
(Caenorhabditis elegans)
Secernentea rmd-6 34
  • 26 (a)
rmd-3 34
  • 25 (a)
rmd-4 34
  • 25 (a)
rmd-1 34
  • 24 (a)
C16C8.18 34
  • 22 (a)
rmd-5 34
  • 21 (a)
rmd-2 34
  • 19 (a)
sup-35 34
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
Species where no ortholog for RMDN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RMDN2 Gene

Gene Tree for RMDN2 (if available)
Gene Tree for RMDN2 (if available)

Paralogs for RMDN2 Gene

Paralogs for RMDN2 Gene

(2) SIMAP similar genes for RMDN2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RMDN2: view

Variants for RMDN2 Gene

Sequence variations from dbSNP and Humsavar for RMDN2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1003412642 uncertain-significance, Primary congenital glaucoma, Peters anomaly 38,068,062(+) A/G/T downstream_transcript_variant
rs162549 likely-benign, Primary congenital glaucoma, Peters anomaly 38,068,313(+) T/A downstream_transcript_variant
rs35320531 uncertain-significance, Primary congenital glaucoma, Peters anomaly 38,068,389(+) C/T downstream_transcript_variant
rs561615550 uncertain-significance, Peters anomaly, Primary congenital glaucoma 38,068,408(+) AAAAA/AAAAAA downstream_transcript_variant
rs886055986 uncertain-significance, Primary congenital glaucoma, Peters anomaly 38,067,644(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RMDN2 Gene

Variant ID Type Subtype PubMed ID
nsv963223 CNV duplication 23825009
nsv516007 CNV gain+loss 19592680
esv3590412 CNV loss 21293372
esv2762251 CNV loss 21179565
esv2719941 CNV deletion 23290073
esv2671607 CNV deletion 23128226
esv2659660 CNV deletion 23128226
dgv6787n54 CNV loss 21841781

Variation tolerance for RMDN2 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RMDN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RMDN2 Gene

Disorders for RMDN2 Gene

Additional Disease Information for RMDN2

No disorders were found for RMDN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RMDN2 Gene

Publications for RMDN2 Gene

  1. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. (PMID: 18070910) Oishi K … Sawa H (The Journal of cell biology 2007) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RMDN2 Gene

Sources for RMDN2 Gene

Loading form....