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Aliases for RMDN1 Gene

Aliases for RMDN1 Gene

  • Regulator Of Microtubule Dynamics 1 2 3 5
  • Family With Sequence Similarity 82, Member B 2 3
  • FAM82B 3 4
  • RMD-1 3 4
  • Regulator Of Microtubule Dynamics Protein 1 3
  • Microtubule-Associated Protein 3
  • Protein FAM82B 4
  • CGI-90 3
  • HRMD-1 4
  • RMD1 3

External Ids for RMDN1 Gene

Previous HGNC Symbols for RMDN1 Gene

  • FAM82B

Previous GeneCards Identifiers for RMDN1 Gene

  • GC08M087481

Summaries for RMDN1 Gene

GeneCards Summary for RMDN1 Gene

RMDN1 (Regulator Of Microtubule Dynamics 1) is a Protein Coding gene. An important paralog of this gene is RMDN3.

Additional gene information for RMDN1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMDN1 Gene

Genomics for RMDN1 Gene

GeneHancer (GH) Regulatory Elements for RMDN1 Gene

Promoters and enhancers for RMDN1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I086507 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 573.4 +6.0 6007 2.6 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF143 ZNF207 RMDN1 WWP1 NTAN1P2 LOC105375624 CPNE3 SLC2A3P4
GH08I086513 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 574.3 -0.4 -412 1.8 ARID4B SIN3A DMAP1 ZBTB7B ZNF48 GLIS2 ELK1 ZNF207 ATF7 SP3 RMDN1 CPNE3 MIOXP1
GH08I086515 Promoter/Enhancer 1.2 EPDnew ENCODE 550.8 -1.5 -1529 0.2 BACH1 EBF1 BMI1 IRF4 ATF7 ETV6 IKZF2 RUNX3 SRF ZBED1 RMDN1 CPNE3 MIOXP1
GH08I086341 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 24.4 +171.0 171000 4.3 PKNOX1 CLOCK FOXA2 ARNT ARID4B NEUROD1 SIN3A ZBTB7B YY1 ZNF766 WWP1 RMDN1 LOC105375624
GH08I086319 Enhancer 1 Ensembl ENCODE 22.3 +194.0 194044 0.8 ELF3 FOXA2 RAD21 RARA YY1 RXRA NR2F2 ZNF148 NFIL3 ATF4 SLC7A13 RMDN1 LOC105375623
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RMDN1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RMDN1 Gene

Genomic Locations for RMDN1 Gene
46,960 bases
Minus strand

Genomic View for RMDN1 Gene

Genes around RMDN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMDN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMDN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMDN1 Gene

Proteins for RMDN1 Gene

  • Protein details for RMDN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Regulator of microtubule dynamics protein 1
    Protein Accession:
    Secondary Accessions:
    • A9UMZ8
    • B4DNF5
    • B4DZW6
    • B5MC61
    • C9JSC6
    • E7EVI2
    • Q9Y398

    Protein attributes for RMDN1 Gene

    314 amino acids
    Molecular mass:
    35808 Da
    Quaternary structure:
    • Interacts with microtubules.

    Alternative splice isoforms for RMDN1 Gene


neXtProt entry for RMDN1 Gene

Post-translational modifications for RMDN1 Gene

  • Ubiquitination at Lys230, isoforms=2, 3243, and isoforms=2261
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RMDN1 Gene

Domains & Families for RMDN1 Gene

Gene Families for RMDN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for RMDN1 Gene


Suggested Antigen Peptide Sequences for RMDN1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RMDN family.
  • Belongs to the RMDN family.
genes like me logo Genes that share domains with RMDN1: view

Function for RMDN1 Gene

genes like me logo Genes that share phenotypes with RMDN1: view

Animal Model Products

CRISPR Products

miRNA for RMDN1 Gene

miRTarBase miRNAs that target RMDN1

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RMDN1 Gene

Localization for RMDN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RMDN1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RMDN1 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Actin filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RMDN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005813 centrosome IDA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with RMDN1: view

Pathways & Interactions for RMDN1 Gene

SuperPathways for RMDN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMDN1 Gene


No data available for Pathways by source and SIGNOR curated interactions for RMDN1 Gene

Drugs & Compounds for RMDN1 Gene

No Compound Related Data Available

Transcripts for RMDN1 Gene

Unigene Clusters for RMDN1 Gene

Regulator of microtubule dynamics 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RMDN1 Gene

No ASD Table

Relevant External Links for RMDN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RMDN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RMDN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RMDN1 Gene

This gene is overexpressed in Heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RMDN1 Gene

Protein tissue co-expression partners for RMDN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RMDN1 Gene:


SOURCE GeneReport for Unigene cluster for RMDN1 Gene:


Evidence on tissue expression from TISSUES for RMDN1 Gene

  • Pancreas(4.2)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with RMDN1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RMDN1 Gene

Orthologs for RMDN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for RMDN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM82B 33
  • 99.58 (n)
RMDN1 34
  • 99 (a)
(Canis familiaris)
Mammalia FAM82B 33
  • 88.85 (n)
RMDN1 34
  • 88 (a)
(Bos Taurus)
Mammalia RMDN1 33 34
  • 86.94 (n)
(Mus musculus)
Mammalia Rmdn1 33 16 34
  • 86.34 (n)
(Rattus norvegicus)
Mammalia Rmdn1 33
  • 86.24 (n)
(Monodelphis domestica)
Mammalia RMDN1 34
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia RMDN1 34
  • 71 (a)
(Gallus gallus)
Aves FAM82B 33 34
  • 72.79 (n)
(Anolis carolinensis)
Reptilia RMDN1 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rmdn1 33
  • 62.28 (n)
Str.15080 33
African clawed frog
(Xenopus laevis)
Amphibia MGC64464 33
(Danio rerio)
Actinopterygii zgc:171674 33
  • 62.34 (n)
RMDN1 34
  • 52 (a)
Dr.12839 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9264 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012364 33
  • 46.19 (n)
(Caenorhabditis elegans)
Secernentea F33H2.6 33 34
  • 49.42 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
Species where no ortholog for RMDN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RMDN1 Gene

Gene Tree for RMDN1 (if available)
Gene Tree for RMDN1 (if available)

Paralogs for RMDN1 Gene

Paralogs for RMDN1 Gene

genes like me logo Genes that share paralogs with RMDN1: view

Variants for RMDN1 Gene

Sequence variations from dbSNP and Humsavar for RMDN1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000210785 -- 86,509,157(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000245737 -- 86,504,532(-) A/G intron_variant
rs1000256821 -- 86,481,062(-) A/G intron_variant
rs1000286794 -- 86,512,443(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000299350 -- 86,504,278(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RMDN1 Gene

Variant ID Type Subtype PubMed ID
nsv1023510 CNV loss 25217958
nsv971681 CNV duplication 23825009

Variation tolerance for RMDN1 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RMDN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RMDN1 Gene

Disorders for RMDN1 Gene

Additional Disease Information for RMDN1

No disorders were found for RMDN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RMDN1 Gene

Publications for RMDN1 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4 58
  2. RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. (PMID: 18070910) Oishi K … Sawa H (The Journal of cell biology 2007) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58

Products for RMDN1 Gene

Sources for RMDN1 Gene

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