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Aliases for RMC1 Gene

Aliases for RMC1 Gene

  • Regulator Of MON1-CCZ1 2 3
  • C18orf8 3 4 5
  • Colon Cancer-Associated Protein Mic1 3 4
  • Chromosome 18 Open Reading Frame 8 2 5
  • WD Repeat Domain 98 2 3
  • MIC-1 3 4
  • MIC1 3 4
  • Colon Cancer Associated Protein Mic1 2
  • Macrophage Inhibitory Cytokine 1 3
  • Uncharacterized Protein C18orf8 3
  • HsT2591 3
  • WDR98 3

External Ids for RMC1 Gene

Previous HGNC Symbols for RMC1 Gene

  • C18orf8
  • WDR98

Summaries for RMC1 Gene

Entrez Gene Summary for RMC1 Gene

  • This gene encodes a colon cancer associated protein. [provided by RefSeq, Jan 2013]

GeneCards Summary for RMC1 Gene

RMC1 (Regulator Of MON1-CCZ1) is a Protein Coding gene.

Additional gene information for RMC1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RMC1 Gene

Genomics for RMC1 Gene

GeneHancer (GH) Regulatory Elements for RMC1 Gene

Promoters and enhancers for RMC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I023502 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 582.9 +0.2 210 2.9 PKNOX1 CLOCK ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF213 ZNF207 RMC1 NPC1 TMEM241 ENSG00000199366 GC18M023583
GH18I023582 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 28.8 +81.5 81520 5.8 HDGF FOXA2 SMAD1 ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 NPC1 RMC1 ANKRD29 CABLES1 TMEM241 CABYR GC18P023587 GC18M023583 ENSG00000199366
GH18I023539 Enhancer 1.3 Ensembl ENCODE dbSUPER 29.2 +37.8 37831 3.1 HDAC1 ATF1 TCF12 ZNF766 ATF7 IKZF2 RUNX3 USF2 ZEB2 MEF2D NPC1 RMC1 ANKRD29 GC18M023583 ENSG00000199366
GH18I022932 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 17.1 -569.3 -569325 3.3 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF143 KLF13 RBBP8 MIR4741 ENSG00000265943 RMC1 LOC101927571 RN7SL745P
GH18I023528 Enhancer 1.2 ENCODE dbSUPER 29.4 +25.9 25910 2.7 PKNOX1 SMAD1 ATF1 ARNT POLR2B ZNF766 GATA2 E2F8 ATF7 FOS RMC1 GC18M023583 ENSG00000199366 NPC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RMC1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RMC1 Gene

Genomic Locations for RMC1 Gene
28,338 bases
Plus strand

Genomic View for RMC1 Gene

Genes around RMC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RMC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RMC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RMC1 Gene

Proteins for RMC1 Gene

  • Protein details for RMC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C18orf8
    Protein Accession:
    Secondary Accessions:
    • Q9BU17
    • Q9Y5M0

    Protein attributes for RMC1 Gene

    657 amino acids
    Molecular mass:
    74975 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD33909.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RMC1 Gene

Post-translational modifications for RMC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RMC1 Gene

Domains & Families for RMC1 Gene

Gene Families for RMC1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for RMC1 Gene

Suggested Antigen Peptide Sequences for RMC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Mic1 family.
  • Belongs to the Mic1 family.
genes like me logo Genes that share domains with RMC1: view

Function for RMC1 Gene

Phenotypes From GWAS Catalog for RMC1 Gene

genes like me logo Genes that share phenotypes with RMC1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RMC1 Gene

Localization for RMC1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RMC1 gene
Compartment Confidence
lysosome 5
endosome 5
nucleus 3
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane HDA 17897319
GO:0031902 late endosome membrane IDA 29038162
GO:0035658 Mon1-Ccz1 complex IDA 29038162
genes like me logo Genes that share ontologies with RMC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RMC1 Gene

Pathways & Interactions for RMC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RMC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010506 regulation of autophagy IMP 29038162
genes like me logo Genes that share ontologies with RMC1: view

No data available for Pathways by source and SIGNOR curated interactions for RMC1 Gene

Drugs & Compounds for RMC1 Gene

No Compound Related Data Available

Transcripts for RMC1 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RMC1 Gene

No ASD Table

Relevant External Links for RMC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RMC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RMC1 Gene:


Evidence on tissue expression from TISSUES for RMC1 Gene

  • Lung(4.2)
  • Nervous system(3.4)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RMC1 Gene

Orthologs for RMC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RMC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C18orf8 34
  • 100 (a)
C18H18orf8 33
  • 99.14 (n)
(Bos Taurus)
Mammalia C18orf8 34
  • 93 (a)
C24H18orf8 33
  • 87.77 (n)
(Monodelphis domestica)
Mammalia C18orf8 34
  • 92 (a)
(Canis familiaris)
Mammalia C18orf8 34
  • 90 (a)
C7H18orf8 33
  • 88.59 (n)
(Mus musculus)
Mammalia 3110002H16Rik 33 16 34
  • 86.96 (n)
(Rattus norvegicus)
Mammalia RGD1311805 33
  • 86.5 (n)
(Ornithorhynchus anatinus)
Mammalia C18orf8 34
  • 84 (a)
(Gallus gallus)
Aves C18orf8 34
  • 85 (a)
C18ORF8 33
  • 79.12 (n)
(Anolis carolinensis)
Reptilia C18orf8 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c18orf8 33
  • 75.7 (n)
Str.18235 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68745 33
(Danio rerio)
Actinopterygii C24H18orf8 34
  • 76 (a)
zgc:101800 33
  • 70.61 (n)
Dr.18809 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007576 33
  • 49.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8270 33 34
  • 48.73 (n)
(Caenorhabditis elegans)
Secernentea Y50D4A.4 33 34
  • 43.35 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G12010 33
  • 40.43 (n)
(Oryza sativa)
Liliopsida Os10g0400900 33
  • 41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8232 34
  • 46 (a)
Species where no ortholog for RMC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RMC1 Gene

Gene Tree for RMC1 (if available)
Gene Tree for RMC1 (if available)

Paralogs for RMC1 Gene

No data available for Paralogs for RMC1 Gene

Variants for RMC1 Gene

Sequence variations from dbSNP and Humsavar for RMC1 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs145236115 uncertain-significance, Niemann-Pick disease, type C 23,531,887(+) CTTTACA/ downstream_transcript_variant
rs1805084 benign, likely-benign, Niemann-Pick disease type C1, not specified, Niemann-Pick disease, type C 23,532,242(+) C/T downstream_transcript_variant
rs188980155 uncertain-significance, Niemann-Pick disease, type C 23,532,093(+) A/C downstream_transcript_variant
rs534888589 uncertain-significance, Niemann-Pick disease, type C 23,532,011(+) G/T downstream_transcript_variant
rs535059744 uncertain-significance, Niemann-Pick disease, type C 23,532,000(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RMC1 Gene

Variant ID Type Subtype PubMed ID
esv34149 CNV loss 18971310
esv3641971 CNV loss 21293372
nsv509688 CNV insertion 20534489
nsv576572 CNV loss 21841781

Variation tolerance for RMC1 Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RMC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RMC1 Gene

Disorders for RMC1 Gene

Additional Disease Information for RMC1

No disorders were found for RMC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RMC1 Gene

Publications for RMC1 Gene

  1. Systematic analysis of human cells lacking ATG8 proteins uncovers roles for GABARAPs and the CCZ1/MON1 regulator C18orf8/RMC1 in macro and selective autophagic flux. (PMID: 29038162) Pontano Vaites L … Harper JW (Molecular and cellular biology 2017) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Knockdown of macrophage inhibitory cytokine-1 in RPMI-8226 human multiple myeloma cells inhibits osteoclastic differentiation through inhibiting the RANKL-Erk1/2 signaling pathway. (PMID: 27779672) Yuan M … Zeng Z (Molecular medicine reports 2016) 3 58

Products for RMC1 Gene

Sources for RMC1 Gene

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