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Aliases for RLF Gene

Aliases for RLF Gene

  • Rearranged L-Myc Fusion 2 3 5
  • Rearranged L-Myc Fusion Gene Protein 3 4
  • Rearranged L-Myc Fusion Sequence 2 3
  • Zn-15-Related Protein 3 4
  • Zinc Finger Protein Rlf 3
  • Zn-15 Related 3
  • ZNF292L 3
  • ZN-15L 3

External Ids for RLF Gene

Previous GeneCards Identifiers for RLF Gene

  • GC01P040661
  • GC01P039630
  • GC01P040090
  • GC01P040040
  • GC01P040296
  • GC01P040399
  • GC01P040627
  • GC01P038745

Summaries for RLF Gene

GeneCards Summary for RLF Gene

RLF (Rearranged L-Myc Fusion) is a Protein Coding gene. An important paralog of this gene is ZNF292.

UniProtKB/Swiss-Prot for RLF Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for RLF Gene

Additional gene information for RLF Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RLF Gene

Genomics for RLF Gene

GeneHancer (GH) Regulatory Elements for RLF Gene

Promoters and enhancers for RLF Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J040160 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.6 586 3 HDGF CLOCK ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 RLF LOC105378671 ENSG00000259943 PPT1 LOC105378674 ENSG00000229528 ZMPSTE24 ENSG00000231296 GC01P040179
GH01J040256 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 37.4 +96.4 96444 3.2 ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 ENSG00000259943 ZMPSTE24 PPIE EXO5 PPIEL TRIT1 RLF NFYC-AS1 NFYC LOC105378672
GH01J040708 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 28.4 +549.9 549869 6.1 PKNOX1 SMAD1 FOXA2 ARNT ARID4B FEZF1 DMAP1 YY1 SLC30A9 POLR2B NFYC EXO5 RLF RIMS3 TRIT1 LOC105378674 NFYC-AS1 MIR30E MIR30C1 LOC105378672
GH01J040379 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.1 +227.4 227397 19.3 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B FEZF1 DMAP1 ZNF2 IRF4 SMAP2 RLF ENSG00000231296 ZMPSTE24 EXO5 LOC105378672 CAP1 MFSD2A PPT1 NFYC
GH01J040372 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15 +214.5 214484 5.9 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 NBN SMAP2 PPIEL EXO5 PPIE TRIT1 ENSG00000259943 NFYC-AS1 RLF LOC105378674 ENSG00000229528
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RLF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RLF gene promoter:
  • NCX
  • Arnt
  • AhR
  • CREB
  • RORalpha1
  • ATF-2
  • CRE-BP1
  • ATF6
  • XBP-1
  • COMP1

Genomic Locations for RLF Gene

Genomic Locations for RLF Gene
79,553 bases
Plus strand
79,553 bases
Plus strand

Genomic View for RLF Gene

Genes around RLF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RLF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RLF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RLF Gene

Proteins for RLF Gene

  • Protein details for RLF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein Rlf
    Protein Accession:
    Secondary Accessions:
    • Q14CQ1
    • Q9NU60

    Protein attributes for RLF Gene

    1914 amino acids
    Molecular mass:
    217953 Da
    Quaternary structure:
    • Interacts with RIT1 and RIT2.
    • In some small cell lung carcinoma (SCLC) cell lines, there is an intrachromosomal rearrangements at 1p32 fusing the first exon of the RLF gene with L-myc.

neXtProt entry for RLF Gene

Post-translational modifications for RLF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RLF Gene

No data available for DME Specific Peptides for RLF Gene

Domains & Families for RLF Gene

Gene Families for RLF Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for RLF Gene

Suggested Antigen Peptide Sequences for RLF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with RLF: view

Function for RLF Gene

Molecular function for RLF Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
rearranged l-myc fusion gene,in small cell lung carcinoma

Phenotypes From GWAS Catalog for RLF Gene

Gene Ontology (GO) - Molecular Function for RLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding NAS 8545128
GO:0005515 protein binding IPI 10545207
GO:0008270 zinc ion binding TAS 8545128
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RLF: view
genes like me logo Genes that share phenotypes with RLF: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RLF

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RLF Gene

Localization for RLF Gene

Subcellular locations from UniProtKB/Swiss-Prot for RLF Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RLF gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IC 8545128
genes like me logo Genes that share ontologies with RLF: view

Pathways & Interactions for RLF Gene

No Data Available

Gene Ontology (GO) - Biological Process for RLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8545128
GO:0015074 DNA integration IDA 1851085
GO:0044030 regulation of DNA methylation IEA --
GO:0045893 positive regulation of transcription, DNA-templated ISS 8545128
genes like me logo Genes that share ontologies with RLF: view

No data available for Pathways by source and SIGNOR curated interactions for RLF Gene

Drugs & Compounds for RLF Gene

No Compound Related Data Available

Transcripts for RLF Gene

mRNA/cDNA for RLF Gene

Unigene Clusters for RLF Gene

Rearranged L-myc fusion:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RLF

Alternative Splicing Database (ASD) splice patterns (SP) for RLF Gene

No ASD Table

Relevant External Links for RLF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RLF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RLF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RLF Gene

This gene is overexpressed in Breast (41.0), Platelet (12.7), and Gallbladder (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RLF Gene

Protein tissue co-expression partners for RLF Gene

NURSA nuclear receptor signaling pathways regulating expression of RLF Gene:


SOURCE GeneReport for Unigene cluster for RLF Gene:


mRNA Expression by UniProt/SwissProt for RLF Gene:

Tissue specificity: Widely expressed in fetal and adult tissues.

Evidence on tissue expression from TISSUES for RLF Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with RLF: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RLF Gene

Orthologs for RLF Gene

This gene was present in the common ancestor of chordates.

Orthologs for RLF Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RLF 34 33
  • 99.6 (n)
(Canis familiaris)
Mammalia RLF 34 33
  • 94.16 (n)
(Bos Taurus)
Mammalia RLF 34 33
  • 92.76 (n)
(Rattus norvegicus)
Mammalia Rlf 33
  • 87.52 (n)
(Mus musculus)
Mammalia Rlf 16 34 33
  • 87.43 (n)
(Monodelphis domestica)
Mammalia RLF 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia RLF 34
  • 65 (a)
(Gallus gallus)
Aves RLF 34 33
  • 69.52 (n)
(Anolis carolinensis)
Reptilia RLF 34
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rlf 33
  • 59.36 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30567 33
(Danio rerio)
Actinopterygii rlf 34 33
  • 51.9 (n)
Species where no ortholog for RLF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RLF Gene

Gene Tree for RLF (if available)
Gene Tree for RLF (if available)
Evolutionary constrained regions (ECRs) for RLF: view image

Paralogs for RLF Gene

Paralogs for RLF Gene

(1) SIMAP similar genes for RLF Gene using alignment to 1 proteins:

  • RLF_HUMAN Pseudogenes for RLF Gene

genes like me logo Genes that share paralogs with RLF: view

Variants for RLF Gene

Sequence variations from dbSNP and Humsavar for RLF Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000006821 -- 40,167,195(+) A/G intron_variant
rs1000101124 -- 40,178,953(+) G/C intron_variant
rs1000104688 -- 40,232,615(+) A/G intron_variant
rs1000163052 -- 40,200,955(+) A/G intron_variant
rs1000167709 -- 40,203,622(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RLF Gene

Variant ID Type Subtype PubMed ID
esv2673542 CNV deletion 23128226
esv2747352 CNV deletion 23290073
esv2758933 CNV loss 17122850
nsv1119679 CNV deletion 24896259
nsv521874 CNV loss 19592680
nsv829660 CNV gain+loss 17160897
nsv947427 CNV duplication 23825009
nsv950676 CNV duplication 24416366

Variation tolerance for RLF Gene

Residual Variation Intolerance Score: 22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.19; 75.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RLF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RLF Gene

Disorders for RLF Gene

Additional Disease Information for RLF

No disorders were found for RLF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RLF Gene

Publications for RLF Gene

  1. The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein. (PMID: 8545128) Mäkelä TP … Alitalo K (Oncogene 1995) 3 4 22 58
  2. Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer. (PMID: 1649386) Mäkelä TP … Alitalo K (Molecular and cellular biology 1991) 2 3 22 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RLF Gene

Sources for RLF Gene

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