Aliases for RITA1 Gene

Aliases for RITA1 Gene

  • RBPJ Interacting And Tubulin Associated 1 2 3 5
  • RITA 2 3 4
  • RBPJ-Interacting And Tubulin-Associated Protein 1 3 4
  • C12orf52 3 4
  • RBPJ-Interacting And Tubulin-Associated Protein 4
  • RBP-J Interacting And Tubulin Associated 2
  • Chromosome 12 Open Reading Frame 52 2
  • FLJ14827 2
  • RITA1 5

External Ids for RITA1 Gene

Previous HGNC Symbols for RITA1 Gene

  • C12orf52

Previous GeneCards Identifiers for RITA1 Gene

  • GC12P113624

Summaries for RITA1 Gene

GeneCards Summary for RITA1 Gene

RITA1 (RBPJ Interacting And Tubulin Associated 1) is a Protein Coding gene. Diseases associated with RITA1 include Anus Cancer. Gene Ontology (GO) annotations related to this gene include tubulin binding.

UniProtKB/Swiss-Prot Summary for RITA1 Gene

  • Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

Additional gene information for RITA1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RITA1 Gene

Genomics for RITA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RITA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RITA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RITA1

Genomic Locations for RITA1 Gene

Genomic Locations for RITA1 Gene
chr12:113,185,526-113,192,368
(GRCh38/hg38)
Size:
6,843 bases
Orientation:
Plus strand
chr12:113,623,331-113,630,173
(GRCh37/hg19)
Size:
6,843 bases
Orientation:
Plus strand

Genomic View for RITA1 Gene

Genes around RITA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RITA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RITA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RITA1 Gene

Proteins for RITA1 Gene

  • Protein details for RITA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K30-RITA1_HUMAN
    Recommended name:
    RBPJ-interacting and tubulin-associated protein 1
    Protein Accession:
    Q96K30
    Secondary Accessions:
    • B3KVZ4
    • C9JIN1
    • F8VRG5
    • Q53GM3
    • Q96K25

    Protein attributes for RITA1 Gene

    Size:
    269 amino acids
    Molecular mass:
    28619 Da
    Quaternary structure:
    • Interacts with RBPJ/RBPSUH.

    Three dimensional structures from OCA and Proteopedia for RITA1 Gene

    Alternative splice isoforms for RITA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RITA1 Gene

Post-translational modifications for RITA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RITA1 Gene

No data available for DME Specific Peptides for RITA1 Gene

Domains & Families for RITA1 Gene

Gene Families for RITA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RITA1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96K30

UniProtKB/Swiss-Prot:

RITA1_HUMAN :
  • Belongs to the RITA family.
Family:
  • Belongs to the RITA family.
genes like me logo Genes that share domains with RITA1: view

No data available for Suggested Antigen Peptide Sequences for RITA1 Gene

Function for RITA1 Gene

Molecular function for RITA1 Gene

UniProtKB/Swiss-Prot Function:
Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

Phenotypes From GWAS Catalog for RITA1 Gene

Gene Ontology (GO) - Molecular Function for RITA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21102556
GO:0015631 tubulin binding IEA,IDA 21102556
genes like me logo Genes that share ontologies with RITA1: view
genes like me logo Genes that share phenotypes with RITA1: view

Animal Model Products

CRISPR Products

miRNA for RITA1 Gene

miRTarBase miRNAs that target RITA1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RITA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RITA1 Gene

Localization for RITA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RITA1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RITA1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
mitochondrion 2
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RITA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 21102556
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA,IDA 21102556
GO:0005813 centrosome IDA 21102556
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with RITA1: view

Pathways & Interactions for RITA1 Gene

PathCards logo

SuperPathways for RITA1 Gene

No Data Available

SIGNOR curated interactions for RITA1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for RITA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 21102556
GO:0007219 Notch signaling pathway IEA --
GO:0007399 nervous system development IEA --
GO:0022008 neurogenesis ISS --
GO:0045746 negative regulation of Notch signaling pathway IDA 21102556
genes like me logo Genes that share ontologies with RITA1: view

No data available for Pathways by source for RITA1 Gene

Drugs & Compounds for RITA1 Gene

No Compound Related Data Available

Transcripts for RITA1 Gene

mRNA/cDNA for RITA1 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RITA1

Alternative Splicing Database (ASD) splice patterns (SP) for RITA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for RITA1 Gene

GeneLoc Exon Structure for
RITA1

Expression for RITA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RITA1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RITA1 Gene



Protein tissue co-expression partners for RITA1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RITA1

Evidence on tissue expression from TISSUES for RITA1 Gene

  • Kidney(4.4)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RITA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RITA1 Gene

Orthologs for RITA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RITA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C12H12orf52 30
  • 99.32 (n)
RITA1 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C26H12orf52 30
  • 83.7 (n)
RITA1 31
  • 77 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RITA1 30
  • 81.16 (n)
RITA 31
  • 75 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Rita1 30 17
  • 74.97 (n)
1110008J03Rik 31
  • 68 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1306772 30
  • 74.81 (n)
Oppossum
(Monodelphis domestica)
Mammalia RITA1 31
  • 50 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RITA1 31
  • 38 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100491156 30
  • 48.12 (n)
Species where no ortholog for RITA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RITA1 Gene

ENSEMBL:
Gene Tree for RITA1 (if available)
TreeFam:
Gene Tree for RITA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RITA1: view image

Paralogs for RITA1 Gene

No data available for Paralogs for RITA1 Gene

Variants for RITA1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RITA1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs16942601 - p.Ser113Trp
rs34831139 - p.Thr220Lys

Additional dbSNP identifiers (rs#s) for RITA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RITA1 Gene

Variant ID Type Subtype PubMed ID
esv3630792 CNV gain 21293372
esv3892265 CNV gain 25118596
nsv519540 CNV gain+loss 19592680

Variation tolerance for RITA1 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RITA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RITA1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RITA1 Gene

Disorders for RITA1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RITA1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
anus cancer
  • anal cancer
- elite association - COSMIC cancer census association via MalaCards
Search RITA1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with RITA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RITA1 Gene

Publications for RITA1 Gene

  1. RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. (PMID: 21102556) Wacker SA … Oswald F (The EMBO journal 2011) 2 3 4
  2. RITA inhibits growth of human hepatocellular carcinoma through induction of apoptosis. (PMID: 24308154) Wang H … Liu C (Oncology research 2013) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  5. Potential involvement of RITA in the activation of Aurora A at spindle poles during mitosis. (PMID: 30705408) Kreis NN … Yuan J (Oncogene 2019) 3

Products for RITA1 Gene

Sources for RITA1 Gene