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Aliases for RIT2 Gene

Aliases for RIT2 Gene

  • Ras Like Without CAAX 2 2 3 5
  • Ras-Like Protein Expressed In Neurons 3 4
  • Ras-Like Without CAAX Protein 2 3 4
  • ROC2 3 4
  • RIN 3 4
  • Ric (Drosophila)-Like, Expressed In Neurons 2
  • Ric-Like, Expressed In Neurons 3
  • GTP-Binding Protein Rit2 3
  • GTP-Binding Protein Roc2 3
  • RIBA 3

External Ids for RIT2 Gene

Previous HGNC Symbols for RIT2 Gene

  • RIN

Previous GeneCards Identifiers for RIT2 Gene

  • GC18M040529
  • GC18M040109
  • GC18M040211
  • GC18M038575
  • GC18M038577
  • GC18M040323
  • GC18M037181

Summaries for RIT2 Gene

Entrez Gene Summary for RIT2 Gene

  • RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RIT2 Gene

RIT2 (Ras Like Without CAAX 2) is a Protein Coding gene. Diseases associated with RIT2 include Gastrointestinal System Disease and Granulomatous Hepatitis. Among its related pathways are RET signaling and Neurotrophic factor-mediated Trk receptor signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and calmodulin binding. An important paralog of this gene is RIT1.

UniProtKB/Swiss-Prot for RIT2 Gene

  • Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator.

Gene Wiki entry for RIT2 Gene

Additional gene information for RIT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIT2 Gene

Genomics for RIT2 Gene

GeneHancer (GH) Regulatory Elements for RIT2 Gene

Promoters and enhancers for RIT2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J043115 Promoter 0.7 EPDnew 650.7 +0.0 31 0.1 GLIS1 PRDM1 RIT2 GC18P043040 GC18M043026 GC18M042978
GH18J042414 Enhancer 0.5 ENCODE 4.7 +701.0 700982 2.5 JUND STAT3 CEBPB EP300 RIT2 GC18P042410 GC18P042554 LINC00907
GH18J042385 Enhancer 0.2 FANTOM5 4.7 +730.2 730164 0.2 RIT2 GC18P042410 GC18P042301 LINC00907
GH18J043129 Enhancer 0.4 Ensembl 0.4 -14.5 -14455 0.5 IRF2 ZBTB17 RIT2 GC18M043169 GC18M042978 GC18M043026
GH18J043034 Enhancer 0.5 ENCODE 0.2 +80.3 80323 2.6 SP1 JUND GATA3 ESR1 BACH1 GC18P043040 GC18M043031 RIT2 GC18M042978 GC18M043026
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RIT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RIT2 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • HOXA3
  • Pbx1a
  • S8

Genomic Locations for RIT2 Gene

Genomic Locations for RIT2 Gene
372,475 bases
Minus strand
372,466 bases
Minus strand

Genomic View for RIT2 Gene

Genes around RIT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIT2 Gene

Proteins for RIT2 Gene

  • Protein details for RIT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTP-binding protein Rit2
    Protein Accession:
    Secondary Accessions:
    • B2R9L1
    • O15295
    • Q8TD69
    • Q8WVF6
    • Q92964

    Protein attributes for RIT2 Gene

    217 amino acids
    Molecular mass:
    24668 Da
    Quaternary structure:
    • Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form (By similarity). Binds calmodulin. Interacts with PLXNB3. Interacts with POU4F1 (via N-terminus); the interaction controls POU4F1 transactivation activity on some neuronal target genes (By similarity).
    • Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.

    Alternative splice isoforms for RIT2 Gene


neXtProt entry for RIT2 Gene

Post-translational modifications for RIT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIT2 Gene

No data available for DME Specific Peptides for RIT2 Gene

Domains & Families for RIT2 Gene

Gene Families for RIT2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RIT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Ras family.
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RIT2: view

Function for RIT2 Gene

Molecular function for RIT2 Gene

UniProtKB/Swiss-Prot Function:
Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator.

Phenotypes From GWAS Catalog for RIT2 Gene

Gene Ontology (GO) - Molecular Function for RIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003924 GTPase activity NAS,IEA 8824319
GO:0005515 protein binding IPI 21957239
GO:0005516 calmodulin binding ISS --
GO:0005525 GTP binding IEA,ISS --
genes like me logo Genes that share ontologies with RIT2: view
genes like me logo Genes that share phenotypes with RIT2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RIT2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RIT2 Gene

Localization for RIT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIT2 Gene

Nucleus. Cell membrane. Note=Colocalizes with PLXNB3 at the plasma membrane (PubMed:16122393). {ECO:0000269 PubMed:16122393}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIT2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for RIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005886 plasma membrane TAS,ISS 8824319
GO:0016020 membrane IEA --
GO:0043005 neuron projection IDA 21957239
genes like me logo Genes that share ontologies with RIT2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RIT2 Gene

Pathways & Interactions for RIT2 Gene

genes like me logo Genes that share pathways with RIT2: view

Gene Ontology (GO) - Biological Process for RIT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 NOT MAPK cascade ISS --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA --
GO:0007264 small GTPase mediated signal transduction NAS 8824319
genes like me logo Genes that share ontologies with RIT2: view

No data available for SIGNOR curated interactions for RIT2 Gene

Drugs & Compounds for RIT2 Gene

(4) Drugs for RIT2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RIT2: view

Transcripts for RIT2 Gene

mRNA/cDNA for RIT2 Gene

Unigene Clusters for RIT2 Gene

Ras-like without CAAX 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RIT2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RIT2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: -

Relevant External Links for RIT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RIT2 Gene

mRNA differential expression in normal tissues according to GTEx for RIT2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.0), Brain - Cerebellum (x8.6), Brain - Frontal Cortex (BA9) (x4.7), Brain - Nucleus accumbens (basal ganglia) (x4.7), Brain - Hypothalamus (x4.4), and Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for RIT2 Gene

This gene is overexpressed in Heart (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RIT2 Gene

Protein tissue co-expression partners for RIT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RIT2 Gene:


SOURCE GeneReport for Unigene cluster for RIT2 Gene:


mRNA Expression by UniProt/SwissProt for RIT2 Gene:

Tissue specificity: Neuron-specific.

Evidence on tissue expression from TISSUES for RIT2 Gene

  • Nervous system(4.3)
  • Blood(2.8)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with RIT2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RIT2 Gene

Orthologs for RIT2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RIT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RIT2 34
  • 98 (a)
(Canis familiaris)
Mammalia RIT2 34 33
  • 91.4 (n)
(Ornithorhynchus anatinus)
Mammalia RIT2 34
  • 91 (a)
(Monodelphis domestica)
Mammalia RIT2 34
  • 90 (a)
(Mus musculus)
Mammalia Rit2 16 34 33
  • 87.35 (n)
(Rattus norvegicus)
Mammalia Rit2 33
  • 87.04 (n)
(Bos Taurus)
Mammalia -- 34
  • 30 (a)
(Gallus gallus)
Aves RIT2 34 33
  • 79.17 (n)
(Anolis carolinensis)
Reptilia RIT2 34
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005159 33
  • 61.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ric 34 33
  • 61.11 (n)
(Caenorhabditis elegans)
Secernentea rap-3 34
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 34
  • 32 (a)
Species where no ortholog for RIT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RIT2 Gene

Gene Tree for RIT2 (if available)
Gene Tree for RIT2 (if available)
Evolutionary constrained regions (ECRs) for RIT2: view image

Paralogs for RIT2 Gene

Variants for RIT2 Gene

Sequence variations from dbSNP and Humsavar for RIT2 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000000659 -- 42,994,091(-) C/T intron_variant
rs1000004332 -- 43,114,702(-) A/G intron_variant
rs1000007772 -- 42,894,757(-) T/C intron_variant
rs1000008864 -- 42,935,782(-) G/A intron_variant
rs1000015849 -- 42,909,144(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RIT2 Gene

Variant ID Type Subtype PubMed ID
esv3360823 CNV insertion 20981092
esv3583031 CNV loss 25503493
esv3642363 CNV loss 21293372
esv3642364 CNV loss 21293372
esv3642365 CNV loss 21293372
esv3642366 CNV gain 21293372
esv990550 CNV insertion 20482838
nsv1113922 CNV deletion 24896259
nsv1117199 CNV tandem duplication 24896259
nsv131143 CNV deletion 16902084
nsv2269 CNV deletion 18451855
nsv458058 CNV loss 19166990
nsv458059 CNV loss 19166990
nsv458060 CNV loss 19166990
nsv470418 CNV loss 18288195
nsv519875 CNV gain 19592680
nsv522338 CNV loss 19592680
nsv526691 CNV loss 19592680
nsv576765 CNV loss 21841781
nsv576766 CNV loss 21841781
nsv576767 CNV loss 21841781
nsv576768 CNV loss 21841781
nsv576769 CNV loss 21841781
nsv833632 CNV loss 17160897
nsv833633 CNV gain 17160897
nsv953534 CNV duplication 24416366

Variation tolerance for RIT2 Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RIT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIT2 Gene

Disorders for RIT2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RIT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gastrointestinal system disease
  • alimentary system disease
granulomatous hepatitis
- elite association - COSMIC cancer census association via MalaCards
Search RIT2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RIT2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RIT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RIT2 Gene

Publications for RIT2 Gene

  1. RIC, a calmodulin-binding Ras-like GTPase. (PMID: 8918462) Wes PD … Montell C (The EMBO journal 1996) 2 3 4 22 58
  2. Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. (PMID: 8824319) Lee CH … Zack DJ (The Journal of neuroscience : the official journal of the Society for Neuroscience 1996) 2 3 4 58
  3. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PMID: 22491018) Wang J … Platt A (The pharmacogenomics journal 2013) 3 44 58
  4. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N … PD GWAS Consortium (Annals of neurology 2012) 3 44 58
  5. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. (PMID: 21738487) Do CB … Eriksson N (PLoS genetics 2011) 3 44 58

Products for RIT2 Gene

Sources for RIT2 Gene

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