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Aliases for RIT1 Gene

Aliases for RIT1 Gene

  • Ras Like Without CAAX 1 2 3 5
  • Ras-Like Protein Expressed In Many Tissues 3 4
  • Ric-Like, Expressed In Many Tissues 2 3
  • Ras-Like Without CAAX Protein 1 3 4
  • GTP-Binding Protein Roc1 2 3
  • RIBB 3 4
  • ROC1 3 4
  • RIT 3 4
  • Ric (Drosophila)-Like, Expressed In Many Tissues 2
  • GTP-Binding Protein Rit1 3
  • NS8 3

External Ids for RIT1 Gene

Previous HGNC Symbols for RIT1 Gene

  • RIT

Previous GeneCards Identifiers for RIT1 Gene

  • GC01M153733
  • GC01M151617
  • GC01M152647
  • GC01M153086
  • GC01M152682
  • GC01M154134
  • GC01M127228

Summaries for RIT1 Gene

Entrez Gene Summary for RIT1 Gene

  • This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

CIViC summary for RIT1 Gene

GeneCards Summary for RIT1 Gene

RIT1 (Ras Like Without CAAX 1) is a Protein Coding gene. Diseases associated with RIT1 include Noonan Syndrome 8 and Noonan Syndrome 1. Among its related pathways are RET signaling and Neurotrophic factor-mediated Trk receptor signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and calmodulin binding. An important paralog of this gene is RIT2.

UniProtKB/Swiss-Prot for RIT1 Gene

  • Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.

Gene Wiki entry for RIT1 Gene

Additional gene information for RIT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RIT1 Gene

Genomics for RIT1 Gene

GeneHancer (GH) Regulatory Elements for RIT1 Gene

Promoters and enhancers for RIT1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J155909 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 670.2 +0.4 401 3.5 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A YY1 SLC30A9 POLR2B ZNF766 RIT1 KRTCAP2 LOC101928120 KHDC4 MSTO2P GON4L ENSG00000271267 CLK2 MSTO1 RRNAD1
GH01J155965 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 33.5 -64.0 -63973 19 MLX ZFP64 FEZF1 DMAP1 IRF4 SLC30A9 ZNF213 ZNF416 ZNF143 ZNF263 ARHGEF2 KHDC4 GON4L CLK2 RIT1 PRCC RRNAD1 ENSG00000271267 THBS3 RUSC1-AS1
GH01J155242 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 18.3 +667.2 667162 2.9 FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 GBA GON4L KHDC4 CLK2 ENSG00000271267 MSTO1 MSTO2P RUSC1-AS1 THBS3 SHC1
GH01J155937 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.8 -31.8 -31815 10.9 HDGF PKNOX1 FOXA2 SMAD1 ARNT MLX ZFP64 ARID4B FEZF1 DMAP1 RXFP4 GON4L CLK2 KHDC4 RRNAD1 YY1AP1 SHC1 THBS3 RIT1 ENSG00000271267
GH01J155930 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.6 -21.5 -21487 5.4 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC GLIS1 KHDC4 GON4L RRNAD1 ISG20L2 CCT3 MSTO2P MSTO1 LOC101928120 CLK2 ENSG00000271267
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RIT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RIT1 gene promoter:
  • CREB
  • deltaCREB
  • CUTL1
  • AREB6
  • Nkx2-5
  • YY1
  • RSRFC4

Genomic Locations for RIT1 Gene

Genomic Locations for RIT1 Gene
13,597 bases
Minus strand
13,597 bases
Minus strand

Genomic View for RIT1 Gene

Genes around RIT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIT1 Gene

Proteins for RIT1 Gene

  • Protein details for RIT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GTP-binding protein Rit1
    Protein Accession:
    Secondary Accessions:
    • B4DQE8
    • O00646
    • O00720
    • Q5VY89
    • Q5VY90

    Protein attributes for RIT1 Gene

    219 amino acids
    Molecular mass:
    25145 Da
    Quaternary structure:
    • Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1 association is dependent upon the GTP-bound state. Interacts with RGL3 (By similarity).
    • Stimulation of the NGF and EGF receptor signaling pathways results in rapid and prolonged activation.
    • Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.

    Three dimensional structures from OCA and Proteopedia for RIT1 Gene

    Alternative splice isoforms for RIT1 Gene


neXtProt entry for RIT1 Gene

Post-translational modifications for RIT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RIT1 Gene

No data available for DME Specific Peptides for RIT1 Gene

Domains & Families for RIT1 Gene

Gene Families for RIT1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Ras family.
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RIT1: view

Function for RIT1 Gene

Molecular function for RIT1 Gene

UniProtKB/Swiss-Prot Function:
Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.
UniProtKB/Swiss-Prot EnzymeRegulation:
Alternates between an inactive form bound to GDP and an active form bound to GTP.

Phenotypes From GWAS Catalog for RIT1 Gene

Gene Ontology (GO) - Molecular Function for RIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,IDA 10545207
GO:0005515 protein binding IPI 10545207
GO:0005516 calmodulin binding TAS 8918462
GO:0005525 GTP binding IDA,IEA 10545207
genes like me logo Genes that share ontologies with RIT1: view
genes like me logo Genes that share phenotypes with RIT1: view

Human Phenotype Ontology for RIT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for RIT1 Gene

MGI Knock Outs for RIT1:
  • Rit1 Rit1<tm1Dand>

Animal Model Products

miRNA for RIT1 Gene

Clone Products

  • Addgene plasmids for RIT1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RIT1 Gene

Localization for RIT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RIT1 Gene

Cell membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIT1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for RIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RIT1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RIT1 Gene

Pathways & Interactions for RIT1 Gene

genes like me logo Genes that share pathways with RIT1: view

Gene Ontology (GO) - Biological Process for RIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA,TAS 8918462
GO:0007265 Ras protein signal transduction IDA 23791108
genes like me logo Genes that share ontologies with RIT1: view

No data available for SIGNOR curated interactions for RIT1 Gene

Drugs & Compounds for RIT1 Gene

(3) Drugs for RIT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RIT1: view

Transcripts for RIT1 Gene

mRNA/cDNA for RIT1 Gene

Unigene Clusters for RIT1 Gene

Ras-like without CAAX 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for RIT1

Alternative Splicing Database (ASD) splice patterns (SP) for RIT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: - -
SP7: - -

Relevant External Links for RIT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RIT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RIT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RIT1 Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for RIT1 Gene

This gene is overexpressed in Heart (55.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RIT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RIT1 Gene:


SOURCE GeneReport for Unigene cluster for RIT1 Gene:


mRNA Expression by UniProt/SwissProt for RIT1 Gene:

Tissue specificity: Expressed in many tissues.

Evidence on tissue expression from TISSUES for RIT1 Gene

  • Eye(4.1)
  • Nervous system(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RIT1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • outer ear
  • scalp
  • skull
  • tooth
  • aorta
  • breast
  • chest wall
  • clavicle
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • abdominal wall
  • liver
  • spleen
  • pelvis
  • placenta
  • testicle
  • uterus
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • lymph node
  • lymph vessel
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with RIT1: view

No data available for Protein tissue co-expression partners for RIT1 Gene

Orthologs for RIT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RIT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RIT1 34 33
  • 99.72 (n)
(Bos Taurus)
Mammalia RIT1 34 33
  • 95.11 (n)
(Canis familiaris)
Mammalia RIT1 34 33
  • 90.26 (n)
(Rattus norvegicus)
Mammalia Rit1 33
  • 87.86 (n)
(Mus musculus)
Mammalia Rit1 16 34 33
  • 87.21 (n)
(Monodelphis domestica)
Mammalia RIT1 34
  • 82 (a)
(Gallus gallus)
Aves RIT1 34 33
  • 79.19 (n)
(Anolis carolinensis)
Reptilia RIT1 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486360 33
  • 71.11 (n)
(Danio rerio)
Actinopterygii rit1 34 33
  • 70.42 (n)
Dr.19738 33
fruit fly
(Drosophila melanogaster)
Insecta Ric 34
  • 47 (a)
(Caenorhabditis elegans)
Secernentea rap-3 34
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSR1 34
  • 32 (a)
Species where no ortholog for RIT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RIT1 Gene

Gene Tree for RIT1 (if available)
Gene Tree for RIT1 (if available)
Evolutionary constrained regions (ECRs) for RIT1: view image

Paralogs for RIT1 Gene

Variants for RIT1 Gene

Sequence variations from dbSNP and Humsavar for RIT1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs34831194 benign, not specified, Noonan syndrome 8 155,904,365(-) G/A coding_sequence_variant, synonymous_variant
rs367785615 likely-benign, Noonan syndrome 8 155,904,721(-) G/T intron_variant
rs375724784 uncertain-significance, Noonan syndrome 8 155,904,406(-) G/A coding_sequence_variant, missense_variant
rs483352822 pathogenic, not-provided, not provided, Noonan syndrome 8, Noonan syndrome, Noonan syndrome 8 (NS8) [MIM:615355] 155,904,470(-) C/A/G/T coding_sequence_variant, missense_variant
rs672601334 pathogenic, Noonan syndrome 8, not provided, Noonan syndrome, Noonan syndrome 8 (NS8) [MIM:615355] 155,904,798(-) G/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for RIT1 Gene

Variant ID Type Subtype PubMed ID
esv33869 CNV loss 17666407

Variation tolerance for RIT1 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RIT1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIT1 Gene

Disorders for RIT1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RIT1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search RIT1 in MalaCards View complete list of genes associated with diseases


  • Noonan syndrome 8 (NS8) [MIM:615355]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. {ECO:0000269 PubMed:23791108, ECO:0000269 PubMed:25959749}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for RIT1

genes like me logo Genes that share disorders with RIT1: view

No data available for Genatlas for RIT1 Gene

Publications for RIT1 Gene

  1. Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. (PMID: 8824319) Lee CH … Zack DJ (The Journal of neuroscience : the official journal of the Society for Neuroscience 1996) 2 3 4 22 58
  2. Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades. (PMID: 15632082) Shi GX … Andres DA (Molecular and cellular biology 2005) 3 4 22 58
  3. RIC, a calmodulin-binding Ras-like GTPase. (PMID: 8918462) Wes PD … Montell C (The EMBO journal 1996) 2 3 4 58
  4. Mutations in RIT1 cause Noonan syndrome - additional functional evidence and expanding the clinical phenotype. (PMID: 25959749) Koenighofer M … Bodamer OA (Clinical genetics 2016) 3 4 58
  5. Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome. (PMID: 23791108) Aoki Y … Matsubara Y (American journal of human genetics 2013) 3 4 58

Products for RIT1 Gene

Sources for RIT1 Gene

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