Subcategory (RNA class) for RIPPLY2 Gene
Aliases for RIPPLY2 Gene
External Ids for RIPPLY2 Gene
Previous HGNC Symbols for RIPPLY2 Gene
Previous GeneCards Identifiers for RIPPLY2 Gene
This gene encodes a nuclear protein that belongs to a novel family of proteins required for vertebrate somitogenesis. Members of this family have a tetrapeptide WRPW motif that is required for interaction with the transcriptional repressor Groucho and a carboxy-terminal Ripply homology domain/Bowline-DSCR-Ledgerline conserved region required for transcriptional repression. Null mutant mice die soon after birth and display defects in axial skeleton segmentation due to defective somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
GeneCards Summary for RIPPLY2 Gene
RIPPLY2 (Ripply Transcriptional Repressor 2) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with RIPPLY2 include Spondylocostal Dysostosis 6, Autosomal Recessive and Spondylocostal Dysostosis, Autosomal Recessive. Among its related pathways are Gene regulatory network modelling somitogenesis. An important paralog of this gene is RIPPLY1.
UniProtKB/Swiss-Prot for RIPPLY2 Gene
Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites (By similarity).