Aliases for RIPOR3 Gene

Aliases for RIPOR3 Gene

  • RIPOR Family Member 3 2 3 4 5
  • Family With Sequence Similarity 65 Member C 2 3
  • C20orf175 3 4
  • C20orf176 3 4
  • FAM65C 3 4
  • Chromosome 20 Open Reading Frame 175 2
  • Chromosome 20 Open Reading Frame 176 2
  • Protein FAM65C 3
  • DJ530I15.2 2
  • DJ530I15.3 2
  • RIPOR3 5

External Ids for RIPOR3 Gene

Previous HGNC Symbols for RIPOR3 Gene

  • C20orf175
  • C20orf176
  • FAM65C

Summaries for RIPOR3 Gene

GeneCards Summary for RIPOR3 Gene

RIPOR3 (RIPOR Family Member 3) is a Protein Coding gene. An important paralog of this gene is RIPOR2.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RIPOR3 Gene

Genomics for RIPOR3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RIPOR3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RIPOR3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RIPOR3

Genomic Locations for RIPOR3 Gene

Latest Assembly
chr20:50,586,108-50,692,004
(GRCh38/hg38)
Size:
105,897 bases
Orientation:
Minus strand

Previous Assembly
chr20:49,202,645-49,308,079
(GRCh37/hg19 by Entrez Gene)
Size:
105,435 bases
Orientation:
Minus strand

chr20:49,202,645-49,308,065
(GRCh37/hg19 by Ensembl)
Size:
105,421 bases
Orientation:
Minus strand

Genomic View for RIPOR3 Gene

Genes around RIPOR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RIPOR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RIPOR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RIPOR3 Gene

Proteins for RIPOR3 Gene

  • Protein details for RIPOR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MK2-RIPR3_HUMAN
    Recommended name:
    RIPOR family member 3
    Protein Accession:
    Q96MK2
    Secondary Accessions:
    • Q5QPB6
    • Q9NQQ2

    Protein attributes for RIPOR3 Gene

    Size:
    946 amino acids
    Molecular mass:
    105290 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RIPOR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RIPOR3 Gene

Post-translational modifications for RIPOR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RIPOR3 Gene

Domains & Families for RIPOR3 Gene

Gene Families for RIPOR3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RIPOR3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RIPOR3 Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM65C (FA65C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96MK2

UniProtKB/Swiss-Prot:

RIPR3_HUMAN :
  • Belongs to the RIPOR family.
Family:
  • Belongs to the RIPOR family.
genes like me logo Genes that share domains with RIPOR3: view

Function for RIPOR3 Gene

Phenotypes From GWAS Catalog for RIPOR3 Gene

Gene Ontology (GO) - Molecular Function for RIPOR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with RIPOR3: view
genes like me logo Genes that share phenotypes with RIPOR3: view

miRNA for RIPOR3 Gene

miRTarBase miRNAs that target RIPOR3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RIPOR3 Gene

Localization for RIPOR3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RIPOR3 gene
Compartment Confidence
mitochondrion 2
plasma membrane 1
extracellular 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RIPOR3 Gene

Pathways & Interactions for RIPOR3 Gene

PathCards logo

SuperPathways for RIPOR3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RIPOR3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RIPOR3 Gene

Drugs & Compounds for RIPOR3 Gene

No Compound Related Data Available

Transcripts for RIPOR3 Gene

mRNA/cDNA for RIPOR3 Gene

2 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for RIPOR3 Gene

No ASD Table

Relevant External Links for RIPOR3 Gene

GeneLoc Exon Structure for
RIPOR3

Expression for RIPOR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RIPOR3

genes like me logo Genes that share expression patterns with RIPOR3: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RIPOR3 Gene

Orthologs for RIPOR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for RIPOR3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FAM65C 30 31
  • 99.15 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FAM65C 30 31
  • 87.6 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FAM65C 30 31
  • 84.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fam65c 30
  • 79.82 (n)
Mouse
(Mus musculus)
Mammalia Fam65c 30 31
  • 79.07 (n)
OneToOne
Ripor3 17
Platypus
(Ornithorhynchus anatinus)
Mammalia FAM65C 31
  • 67 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FAM65C 31
  • 66 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FAM65C 30 31
  • 59.96 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FAM65C 31
  • 52 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam65c 30
  • 61.83 (n)
Zebrafish
(Danio rerio)
Actinopterygii zgc:113070 30
  • 52.05 (n)
FAM65C 31
  • 35 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea C27H2.2 31
  • 17 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 19 (a)
OneToMany
Species where no ortholog for RIPOR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RIPOR3 Gene

ENSEMBL:
Gene Tree for RIPOR3 (if available)
TreeFam:
Gene Tree for RIPOR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RIPOR3: view image

Paralogs for RIPOR3 Gene

Paralogs for RIPOR3 Gene

genes like me logo Genes that share paralogs with RIPOR3: view

Variants for RIPOR3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RIPOR3 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs141033220 Uncertain Significance: Malignant tumor of prostate 50,630,793(-) C/T
NM_001290268.2(RIPOR3):c.67G>A (p.Val23Met)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs35965508 - p.Cys566Ser
rs6020624 - p.Leu580Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RIPOR3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RIPOR3 Gene

Variant ID Type Subtype PubMed ID
esv1002485 CNV deletion 20482838
esv1006667 CNV deletion 20482838
esv1383548 CNV insertion 17803354
esv2667883 CNV deletion 23128226
esv2722503 CNV deletion 23290073
esv3646045 CNV loss 21293372
nsv1124835 CNV duplication 24896259
nsv1131595 CNV deletion 24896259
nsv834001 CNV loss 17160897
nsv979439 CNV duplication 23825009

Variation tolerance for RIPOR3 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RIPOR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RIPOR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RIPOR3 Gene

Disorders for RIPOR3 Gene

Additional Disease Information for RIPOR3

No disorders were found for RIPOR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RIPOR3 Gene

Publications for RIPOR3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3

Products for RIPOR3 Gene

Sources for RIPOR3 Gene